Abstract:
OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid of gingivitis and chronic periodontitis patients and effect of periodontal therapy on OSM concentration in GCF of chronic periodontitis patients. DESIGN:A total of 60 subjects were divided into three groups (n=20) based on gingival index (GI), probing pocket depth (PPD) and clinical attachment loss (CAL): healthy (group I), gingivitis (group II) and chronic periodontitis (group III). A fourth group (group IV) consisted of 20 subjects from group III, 8 weeks after treatment i.e. scaling and root planning (SRP). GCF samples were collected from all the groups to estimate the levels of OSM using Enzyme-Linked ImmunoSorbentAssay (ELISA). RESULT:The mean OSM concentrations in GCF was found to be the highest in group III i.e. 0.81+/-0.33 pg/microl. The mean OSM concentration in group I was 0.0689+/-0.022 pg/microl in GCF and in group IV it was 0.0943+/-0.037 g/microl). For group II the mean OSM concentration in GCF 0.125+/-0.023 pg/microl, was fell in between the concentrations obtained in groups I and III. CONCLUSIONS:The greater the amount of periodontal tissue destruction there is substantial increase in GCF OSM concentrations. Since, OSM levels are positively correlated with PPD and CAL, it can be considered as an inflammatory biomarker in periodontal diseases.
journal_name
Cytokinejournal_title
Cytokineauthors
Thorat Manojkumar S,Pradeep AR,Garg G,Raju Adoi
10.1016/j.cyto.2010.02.002subject
Has Abstractpub_date
2010-06-01 00:00:00pages
248-52issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(10)00026-8journal_volume
50pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.03.013
更新日期:2004-07-07 00:00:00
abstract::Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.007
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.019
更新日期:2009-01-01 00:00:00
abstract::Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.008
更新日期:2018-10-01 00:00:00
abstract::Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SL...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.10.023
更新日期:2019-01-01 00:00:00
abstract::Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0191
更新日期:1997-07-01 00:00:00
abstract::Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.10.017
更新日期:2013-01-01 00:00:00
abstract:RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.12.020
更新日期:2013-03-01 00:00:00
abstract::Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.025
更新日期:2017-11-01 00:00:00
abstract::The present study aims to characterize the role of the citrulline-nitric oxide cycle in the response of adult human and rat pancreatic islets to cytokines. Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 bet...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0086
更新日期:1996-08-01 00:00:00
abstract::In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00099-1
更新日期:2003-04-01 00:00:00
abstract::Over the last two decades, a lot of research work has been focused on the interferon (IFN)-regulated JAK-STAT pathway and understanding the mechanisms governing the transcription of interferon stimulated genes (ISGs). Evidence suggests that the JAK-STAT pathway alone does not account in its entirety for mediating cell...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.03.019
更新日期:2010-10-01 00:00:00
abstract::IL-18 is a pleiotropic and multifunctional cytokine that belongs to the IL-1 family. It is produced as a biologically inactive precursor, which is cleaved into its active mature form mainly by caspase-1. The caspase becomes active from its inactive precursor (procaspase-1) upon assembly of an inflammasome. Because of ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2016.01.006
更新日期:2016-06-01 00:00:00
abstract::D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2012.03.014
更新日期:2012-07-01 00:00:00
abstract::Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155089
更新日期:2020-07-01 00:00:00
abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.05.015
更新日期:2009-08-01 00:00:00
abstract::Murine fibrosarcoma L929 cells were transfected with human Fas cDNA. The mode of cell death was analysed following treatment either with tumour necrosis factor (TNF) or with agonistic antibodies to Fas. While triggering of the TNF receptors led to necrosis, clustering of the Fas antigen resulted in apoptotic cell deat...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0252
更新日期:1997-11-01 00:00:00
abstract::Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0142
更新日期:1997-02-01 00:00:00
abstract::To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistoc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.02.013
更新日期:2009-06-01 00:00:00
abstract::The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2014.09.012
更新日期:2015-02-01 00:00:00
abstract::Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold. iNKT cells have the ability to respond as innate immune cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2010.04.016
更新日期:2010-09-01 00:00:00
abstract::Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.0875
更新日期:2002-05-07 00:00:00
abstract::Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0791
更新日期:2001-01-07 00:00:00
abstract::Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2011.12.025
更新日期:2012-04-01 00:00:00
abstract::Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154931
更新日期:2020-03-01 00:00:00
abstract::TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.005
更新日期:2013-10-01 00:00:00
abstract::We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.08.007
更新日期:2008-10-01 00:00:00
abstract::This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.12.026
更新日期:2017-04-01 00:00:00
abstract::The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0092
更新日期:1996-09-01 00:00:00
abstract::Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.07.470
更新日期:2008-10-01 00:00:00