Abstract：
:Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozygous, dominant model, recessive model and allele, respectively. A total of 15 case-control studies were identified, among which, 13 studies (1815 cases and 3501 controls) were eligible for CYP1A1 Ile(462)Val and nine studies (2495 cases and 3553 controls) were eligible for CYP1A1 Msp1. Overall, Ile(462)Val was significantly associated with ovarian cancer, with homozygous carriers (Val/Val vs. Ile/Ile: OR=2.64; 95% CI: 1.63-4.28) and recessive model (Val/Val vs. Ile/Ile and Ile/Val: OR=2.30; 95% CI: 1.45-3.65) being risk factors for ovarian cancer development. In the subgroup analysis by ethnicity, significantly increased risks were found for Caucasians (homozygous carriers: OR=4.91; 95% CI: 2.07-11.66; recessive model: OR=3.26; 95% CI: 1.41-7.50) and Asians (homozygous carriers: OR=3.06; 95% CI: 1.48-6.33; recessive model: OR=2.75; 95% CI: 1.40-5.41; Val allele: OR=1.67; 95% CI: 1.19-2.35). However, no significant associations were found between Msp1 and ovarian cancer in the overall analyses or the subgroup analyses by ethnicity. This meta-analysis denotes the importance for in-depth research regarding of gene-gene, gene-environment interactions, race-specific and histological subtypes specific to obtain a more conclusive response about the function of CYP1A1 in ovarian cancer.
journal_name
Cytokinejournal_title
Cytokineauthors
Huang M,Chen Q,Xiao J,Zhao X,Liu Cdoi
10.1016/j.cyto.2011.12.025subject
Has Abstractpub_date
2012-04-01 00:00:00pages
73-8issue
1eissn
1043-4666issn
1096-0023pii
S1043-4666(12)00003-8journal_volume
58pub_type
杂志文章,meta分析相关文献
CYTOKINE文献大全abstract：:Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155025
更新日期：2020-05-01 00:00:00
abstract：:This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...
journal_title：Cytokine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.cyto.2016.12.026
更新日期：2017-04-01 00:00:00
abstract：:Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155089
更新日期：2020-07-01 00:00:00
abstract：:The human interferon alpha-receptor (IFNAR gene product or IFN alpha R protein) was expressed in hamster CHO cells and in mouse A9 cells. The response of the IFN alpha R cDNA transfectants to human IFNs was studied by measuring induction of (2'-5') A synthetase (2'-5' AS). In the murine cells, the IFN alpha R protein ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(94)90066-3
更新日期：1994-07-01 00:00:00
abstract：:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2002.1971
更新日期：2002-09-21 00:00:00
abstract：:Interleukin 17 (IL-17) as one of the pro-inflammatory cytokines is a very important player in the immune response to many pathogens and seems to play a role also in certain chronic and autoimmune diseases. Many studies showing the importance of this cytokine were conducted on murine models and human patients. In recen...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2013.06.002
更新日期：2013-10-01 00:00:00
abstract：:Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2019.154882
更新日期：2020-02-01 00:00:00
abstract：:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2019.154735
更新日期：2019-09-01 00:00:00
abstract：:We present evidence that cervical cancer cells express a functional IL-2 receptor (IL-2R). In fact, by RT-PCR we obtained that the IL-2R is present in CALO, and INBL cells, and that it consisted of the alphaIL-2R, betaIL-2R, and gammaIL-2R chains. We also found that IL-2 is a growth factor for these cell lines, and un...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.02.013
更新日期：2010-06-01 00:00:00
abstract：:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2015.04.009
更新日期：2015-10-01 00:00:00
abstract：:Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2007.09.014
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...
journal_title：Cytokine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.cyto.2016.11.016
更新日期：2017-03-01 00:00:00
abstract：:The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2009.08.005
更新日期：2009-12-01 00:00:00
abstract：:Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2000.0778
更新日期：2000-11-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2013.04.009
更新日期：2013-07-01 00:00:00
abstract：:The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.10.005
更新日期：2007-12-01 00:00:00
abstract：:Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2004.12.011
更新日期：2005-05-07 00:00:00
abstract：:Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nod...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2006.08.002
更新日期：2006-08-01 00:00:00
abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(92)90066-z
更新日期：1992-07-01 00:00:00
abstract：:BAFF is associated with various immunological diseases. Previously, we have reported that mouse B cell activating factor (mBAFF) expression was dependent on nuclear localization of co-activator, p300 and the activation of transcription factors including NF-κB and CREB. Here, we investigated whether transcription facto...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.03.017
更新日期：2012-07-01 00:00:00
abstract：:TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2013.05.005
更新日期：2013-10-01 00:00:00
abstract：:Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(91)90018-9
更新日期：1991-05-01 00:00:00
abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1995.1002
更新日期：1995-01-01 00:00:00
abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2014.05.013
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.04.008
更新日期：2012-08-01 00:00:00
abstract：:Epithelial cell apoptosis triggered cooperatively by multiple cytokines contributes to the injury induced by inflammatory responses in the lung and elsewhere. Here we show that interferon-gamma (IFN-gamma) sensitizes A549 cells, human lung epithelial cells, to cytokine-mediated apoptosis by upregulating caspase-8 expr...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2003.2008
更新日期：2002-12-21 00:00:00
abstract：:FK506 suppresses activation of T cells; however, it down-regulates E-selectin, ICAM-1 and VCAM-1 expression in inflamed tissues. In this study, we investigated the effect of FK506 on expression of those adhesion molecules on human vascular endothelial cells (HMVEC). Culture supernatant from peripheral blood mononuclea...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2004.04.006
更新日期：2005-01-21 00:00:00
abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2017.09.004
更新日期：2019-10-01 00:00:00
abstract：:Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2017.09.020
更新日期：2018-03-01 00:00:00
abstract：:ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2017.12.003
更新日期：2018-07-01 00:00:00
