Abstract:
:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a reported Cynomolgus CCR3 (98.0%). Stably-transfected Cynomolgus CCR3 bound human eotaxin (CCL11) with similar kinetics (Kd 240 pM) and was responsive to human CCR3 ligands (eotaxin [CCL11], eotaxin-2 [CCL24], and MCP4 [CCL13]) in Ca(2+) mobilization and chemotaxis assays, thus provides a useful alternative species model system for the analysis of modulators of eotaxin--CCR3 induced signaling and activation.
journal_name
Cytokinejournal_title
Cytokineauthors
Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KBdoi
10.1006/cyto.2002.1971keywords:
subject
Has Abstractpub_date
2002-09-21 00:00:00pages
276-86issue
6eissn
1043-4666issn
1096-0023pii
S104346660291971Xjournal_volume
19pub_type
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