Molecular cloning and functional characterization of Cynomolgus monkey (Macaca fascicularis) CC chemokine receptor, CCR3.

Abstract:

:We have cloned and performed the first functional characterization of the chemokine receptor, CCR3, of Cynomolgus monkey (Macaca fascicularis). The deduced amino acid sequence of the cloned Cynomolgus CCR3 was found to be more similar to that of a previously-reported Rhesus (Macaca mulatta) CCR3 (99.4%) than that of a reported Cynomolgus CCR3 (98.0%). Stably-transfected Cynomolgus CCR3 bound human eotaxin (CCL11) with similar kinetics (Kd 240 pM) and was responsive to human CCR3 ligands (eotaxin [CCL11], eotaxin-2 [CCL24], and MCP4 [CCL13]) in Ca(2+) mobilization and chemotaxis assays, thus provides a useful alternative species model system for the analysis of modulators of eotaxin--CCR3 induced signaling and activation.

journal_name

Cytokine

journal_title

Cytokine

authors

Iino T,Sugimoto H,Watanabe A,Encinas JA,Liu N,Floeckner J,Bacon KB

doi

10.1006/cyto.2002.1971

keywords:

subject

Has Abstract

pub_date

2002-09-21 00:00:00

pages

276-86

issue

6

eissn

1043-4666

issn

1096-0023

pii

S104346660291971X

journal_volume

19

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • CCR7 signaling in pediatric opsoclonus-myoclonus: upregulated serum CCL21 expression is steroid-responsive.

    abstract::Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.05.020

    authors: Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

    更新日期:2013-10-01 00:00:00

  • Visfatin protein may be responsible for suppression of proliferation and apoptosis in the infantile mice ovary.

    abstract::Visfatin is an important adipokines, which are expressed in different tissues including ovary of mammals. The postnatal ovary in rodents undergoes dramatic changes of intra-ovarian factors in relation to proliferation and apoptosis. There are studies which showed that gonadal visfatin changes in postnatal life. Howeve...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2021.155422

    authors: Annie L,Gurusubramanian G,Kumar Roy V

    更新日期:2021-01-18 00:00:00

  • Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism.

    abstract:OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.06.023

    authors: Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith P

    更新日期:2011-11-01 00:00:00

  • TLR7 and TLR8 agonist resiquimod (R848) differently regulates MIF expression in cells and organs.

    abstract::Since its first description in 1966, macrophage migration inhibitory factor (MIF) was found to play a critical role in inflammatory and immune responses as well as in disease pathogenesis especially in tumor pathogenesis and cancer progression. MIF is expressed in different cell types and is associated with many disea...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2017.06.006

    authors: Adzavon YM,Zhao P,Lv B,Liu M,Zhang X,Xie F,Yang L,Shang L,Zhang M,Li Q,Ma X

    更新日期:2017-09-01 00:00:00

  • Modulation of PGE(2) and TNFalpha by nitric oxide and LPS-activated RAW 264.7 cells.

    abstract::Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1955

    authors: Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

    更新日期:2002-08-21 00:00:00

  • T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships.

    abstract::Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2009.07.007

    authors: Garrett WS,Glimcher LH

    更新日期:2009-10-01 00:00:00

  • The association between common genetic variant of microRNA-146a and cancer susceptibility.

    abstract::Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...

    journal_title:Cytokine

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.cyto.2011.09.001

    authors: Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

    更新日期:2011-12-01 00:00:00

  • Macrophage activation for the production of immunostimulatory cytokines by delivering interleukin 1 via biodegradable microspheres.

    abstract::Interleukin 1alpha (IL-1alpha), a pleiotropic cytokine with multiple anti-tumour activities, has been investigated in our laboratory for its potential to serve as an immunotherapeutic agent. In the present study, an attempt was made to direct IL-1alpha to macrophages, in order to induce their immunoregulatory activiti...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2000.0775

    authors: Mullerad J,Cohen S,Voronov E,Apte RN

    更新日期:2000-11-01 00:00:00

  • Inflammations mediators and circulating levels of matrix metalloproteinases: Biomarkers of diabetes in Tunisians metabolic syndrome patients.

    abstract:AIMS:This study investigates the relationships between matrix metalloproteinases, inflammations mediators and type 2 diabetes mellitus in Tunisians metabolic syndrome (Mets) patients. METHODS:The study has included 239 MetS patients and 247 controls. Mets was defined according to the NCEP-ATPIII report. Mets patients ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2016.07.009

    authors: Zayani Y,El Golli N,Zidi W,Guizani I,Boussairi S,Aloui S,Ayadi I,Ftouhi B,Feki M,Ben Romdhane N,Ben Sliman H,Allal-Elasmi M,Kaabachi N

    更新日期:2016-10-01 00:00:00

  • The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.

    abstract:BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.05.022

    authors: Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

    更新日期:2013-10-01 00:00:00

  • Quantification and in situ localization of MCP-1 mRNA and its relation to the immune response of renal cell carcinoma.

    abstract::Malignant tumours are usually accompanied by an immune response. Chemokines such as MCP-1 have been claimed to be potent inducers of such tumour-associated reactions. In the present study MCP-1 mRNA was quantified by competitive reverse transcription polymerase reaction and localised by in situ hybridisation in renal ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2000.0823

    authors: Hemmerlein B,Johanns U,Kugler A,Reffelmann M,Radzun HJ

    更新日期:2001-02-21 00:00:00

  • Role of the citrulline-nitric oxide cycle in the functional response of adult human and rodent pancreatic islets to cytokines.

    abstract::The present study aims to characterize the role of the citrulline-nitric oxide cycle in the response of adult human and rat pancreatic islets to cytokines. Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 bet...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0086

    authors: Flodström M,Morris SM Jr,Eizirik DL

    更新日期:1996-08-01 00:00:00

  • Baseline epicardial adipose tissue adiponectin levels predict cardiovascular outcomes: a long-term follow-up study.

    abstract:OBJECTIVE:Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV complications during long-...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.08.012

    authors: Teijeira-Fernandez E,Eiras S,Salgado Somoza A,Gonzalez-Juanatey JR

    更新日期:2012-12-01 00:00:00

  • Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis.

    abstract::Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.08.032

    authors: Oishi K,Mimura-Kimura Y,Miyasho T,Aoe K,Ogata Y,Katayama H,Murata Y,Ueoka H,Matsumoto T,Mimura Y

    更新日期:2013-01-01 00:00:00

  • Investigating T cell activation and tolerance in vivo: peptide challenge in allergic asthmatics.

    abstract::In the atopic allergic individual, challenge with allergen elicits manifestations of both the humoral (IgE-mediated or early-phase reaction) and the cell-mediated immune response (late-phase reaction). Detailed study of late-phase cell-mediated events is confounded by the effects of the earlier IgE-mediated response w...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2004.07.001

    authors: Smith TR,Larché M

    更新日期:2004-10-21 00:00:00

  • H-Ras-specific upregulation of granulocyte colony-stimulating factor promotes human breast cell invasion via matrix metalloproteinase-2.

    abstract::Ras expression has been suggested to be a marker for tumor aggressiveness of breast cancer. We previously showed that H-Ras, but not N-Ras, induced invasive/migratory phenotypes in MCF10A human breast epithelial cells. The present study aimed to determine the role of granulocyte colony-stimulating factor in H-Ras-indu...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.03.002

    authors: Park S,Kim ES,Noh DY,Hwang KT,Moon A

    更新日期:2011-07-01 00:00:00

  • Association of interleukin (IL)-4 variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms with susceptibility to pediatric autoimmune hepatitis type 1.

    abstract:OBJECTIVE:Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease mediated by an autoimmune reaction to hepatocytes, the present study aimed to assess the possible associations between interleukin-4 (IL-4) variable number of tandem repeats (VNTRs) and IL-4-590 promoter polymorphisms and susceptibility to aut...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.01.009

    authors: Mansour AI,Behairy OG,Abd Almonaem ER,Abd-Rabuh RM,Ahmed IAE

    更新日期:2018-10-01 00:00:00

  • The effect of etanercept and infliximab on the production of tumour necrosis factor alpha, interferon-gamma and GM-CSF in in vivo activated intestinal T lymphocyte cultures.

    abstract:BACKGROUND/AIMS:Infliximab (Ifx) is effective in the treatment of Crohn's disease (CD) and rheumatoid arthritis (RA), etanercept (Eta) in RA but not in CD. The mechanisms underlying these clinical differences are not fully understood, but this knowledge could be valuable to identify responders and develop new treatment...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00201-1

    authors: Agnholt J,Dahlerup JF,Kaltoft K

    更新日期:2003-08-07 00:00:00

  • Human neutrophils produce IL-12, IL-10, PGE2 and LTB4 in response to Paracoccidioides brasiliensis. Involvement of TLR2, mannose receptor and dectin-1.

    abstract::The functions of phagocytic cells against pathogens are initiated by the interaction between membrane receptors and molecular structures which compose the cell wall of these microorganisms. Thus our study aimed to identify the neutrophil receptors involved in the recognition of different strains of Paracoccidioides br...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2014.02.004

    authors: Balderramas HA,Penitenti M,Rodrigues DR,Bachiega TF,Fernandes RK,Ikoma MR,Dias-Melicio LA,Oliveira SL,Soares ÂM

    更新日期:2014-05-01 00:00:00

  • Impact of telmisartan on the inflammatory state in patients with coronary atherosclerosis--influence on IP-10, TNF-α and MCP-1.

    abstract:BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.02.001

    authors: Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

    更新日期:2013-05-01 00:00:00

  • Direct contact with stimulated T cells induces the expression of IL-1beta and IL-1 receptor antagonist in human monocytes. Involvement of serine/threonine phosphatases in differential regulation.

    abstract::Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1997.0191

    authors: Vey E,Dayer JM,Burger D

    更新日期:1997-07-01 00:00:00

  • Inhaled delivery of Interferon-lambda restricts epithelial-derived Th2 inflammation in allergic asthma.

    abstract::The possibility has been suggested that interferon (IFN)-λs can be induced rapidly for restricting respiratory viral infection in asthmatic mice and may modulate Th2-related immune responses that underlie the pathogenesis of asthma. We sought to determine the in vivo contribution of IFN-λs on decrease of Th2 cytokines...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2019.02.010

    authors: Won J,Gil CH,Jo A,Kim HJ

    更新日期:2019-07-01 00:00:00

  • Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

    abstract::Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1989

    authors: Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

    更新日期:2002-11-07 00:00:00

  • Regulation of transforming growth factor-beta secretion by human peritoneal mesothelial and ovarian carcinoma cells.

    abstract::This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1999.0632

    authors: Abendstein B,Stadlmann S,Knabbe C,Buck M,Müller-Holzner E,Zeimet AG,Marth C,Obrist P,Krugmann J,Offner FA

    更新日期:2000-07-01 00:00:00

  • Expression of cytokines and their receptors by psoriatic fibroblasts. II. decreased TNF receptor expression.

    abstract::Psoriatic fibroblasts produce enhanced amounts of IL-6 in vitro. This state of activation may reflect an altered expression of cytokine receptors, involved in auto/paracrine induction of IL-6. Cultures of dermal fibroblasts derived from lesional psoriatic (PP) and normal control (NN) skin were therefore analysed for t...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0011

    authors: Debets R,Hegmans JP,Buurman WA,Benner R,Prens EP

    更新日期:1996-01-01 00:00:00

  • Genetic and environmental influences on IL-6 and TNF-alpha plasma levels in apparently healthy general population.

    abstract::Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.2002.1959

    authors: Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

    更新日期:2002-08-07 00:00:00

  • Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.

    abstract::Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.06.315

    authors: Ashlin TG,Kwan AP,Ramji DP

    更新日期:2013-10-01 00:00:00

  • Mechanisms of tumor necrosis factor-alpha-induced leaks in intestine epithelial barrier.

    abstract:PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.04.008

    authors: He F,Peng J,Deng XL,Yang LF,Camara AD,Omran A,Wang GL,Wu LW,Zhang CL,Yin F

    更新日期:2012-08-01 00:00:00

  • Lower epicardial adipose tissue adiponectin in patients with metabolic syndrome.

    abstract:BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.01.016

    authors: Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

    更新日期:2011-05-01 00:00:00

  • Resident joint tissues, rather than infiltrating neutrophils and monocytes, are the predominant sources of TNF-alpha in zymosan-induced arthritis.

    abstract::Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0018

    authors: Pettipher ER,Salter ED

    更新日期:1996-02-01 00:00:00