RETRACTED: Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in Type 2 diabetes.

abstract：:The pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) involves an abnormal chemokine regulation. The chemokine receptor CCR4 is necessary for T cell migration to the skin. We, therefore, studied if CCR4 and its ligand macrophage-derived chemokine (MDC/CCL22) could participate in spreading the dis...

journal_title：Cytokine

authors： Flytlie HA,Hvid M,Lindgreen E,Kofod-Olsen E,Petersen EL,Jørgensen A,Deleuran M,Vestergaard C,Deleuran B

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

journal_title：Cytokine

authors： Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To describe the relationship between the two mechanisms involved in sIL6R generation in rheumatoid arthritis (RA). METHOD:RA patients were selected from a group of subjects genotyped for the rs8192284 SNP, located at the proteolytic cleavage site of IL-6R. sIL6R and protease levels (ADAM17) were measured and...

journal_title：Cytokine

authors： Lamas JR,Rodríguez-Rodríguez L,Tornero-Esteban P,Villafuertes E,Hoyas J,Abasolo L,Varadé J,Alvarez-Lafuente R,Urcelay E,Fernández-Gutiérrez B

更新日期：2013-03-01 00:00:00

abstract：:Although G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield i...

journal_title：Cytokine

authors： Aerts-Kaya F,Kilic E,Köse S,Aydin G,Cagnan I,Kuskonmaz B,Uckan-Cetinkaya D

更新日期：2020-12-28 00:00:00

abstract：:MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition ...

journal_title：Cytokine

authors： Alosaimi B,Hamed ME,Naeem A,Alsharef AA,AlQahtani SY,AlDosari KM,Alamri AA,Al-Eisa K,Khojah T,Assiri AM,Enani MA

更新日期：2020-02-01 00:00:00

abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...

journal_title：Cytokine

authors： Lorenzo F,Jaulin C,Jankovic DL,Theze J

更新日期：1992-07-01 00:00:00

abstract：:The eph family is the largest subfamily of receptor tyrosine kinases (RTKs). Members of this subfamily display specific expression in the developing and adult brain. Recently, cDNAs encoding membrane bound ligands for these receptors have been identified which we have termed LERKs (ligand for eph-related kinases). We ...

journal_title：Cytokine

authors： Kozlosky CJ,VandenBos T,Park L,Cerretti DP,Carpenter MK

更新日期：1997-08-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine having primarily anti-apoptotic and anti-inflammatory effects. Recent reports have documented that IL-6 plays a key role in liver regeneration. Intracellular deficiency of S-adenosylmethionine (SAMe) is a hallmark of toxin-induced liver injury. Although the administra...

journal_title：Cytokine

authors： Song Z,Chen T,Deaciuc IV,Uriarte S,Hill D,Barve S,McClain CJ

更新日期：2004-12-21 00:00:00

abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

journal_title：Cytokine

authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

更新日期：2019-04-01 00:00:00

abstract：:Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....

journal_title：Cytokine

authors： Garrett WS,Glimcher LH

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...

journal_title：Cytokine

authors： Bedoui SA,Barbirou M,Stayoussef M,Dallel M,Mokrani A,Makni L,Mezlini A,Bouhaouala B,Yacoubi-Loueslati B,Almawi WY

更新日期：2018-10-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

journal_title：Cytokine

authors： Bumiller A,Götz F,Rohde W,Dörner G

更新日期：1999-03-01 00:00:00

abstract：:Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. Oral epithelial cells are involved in innate immunity against Candida infections via Toll-like receptors (TLRs) and inflammatory mediators. We investig...

journal_title：Cytokine

authors： Décanis N,Savignac K,Rouabhia M

更新日期：2009-02-01 00:00:00

abstract：:Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...

journal_title：Cytokine

authors： Hou H,Kang Y,Zeng Y,Li Y,Shang J

更新日期：2018-02-01 00:00:00

abstract：:Periodontitis is the most prevalent infectious disease caused by periodontopathic bacteria and is also a chronic inflammatory disease. Gingival crevicular fluid (GCF) is an inflammatory exudate that seeps into the gingival crevices or periodontal pockets around teeth with inflamed gingiva, and contains various materia...

journal_title：Cytokine

authors： Yoshimoto T,Fujita T,Kajiya M,Matsuda S,Ouhara K,Shiba H,Kurihara H

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Functions of the Th9 cells and its signature cytokine IL-9 in human autoimmune diseases is currently under extensive research. Here we are reporting new functions of IL-9-receptor (IL-9R); its regulatory role on (i) FLS (fibroblast like synoviocyte) biology and (ii) pannus formation in rheumatoid arthritis (R...

journal_title：Cytokine

authors： Raychaudhuri SK,Abria C,Maverakis EM,Raychaudhuri SP

更新日期：2018-11-01 00:00:00

abstract：:Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...

journal_title：Cytokine

authors： Akman-Demir G,Tüzün E,Içöz S,Yeşilot N,Yentür SP,Kürtüncü M,Mutlu M,Saruhan-Direskeneli G

更新日期：2008-12-01 00:00:00

abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

journal_title：Cytokine

authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

更新日期：1995-01-01 00:00:00

abstract：:The oligoadenylate synthetase (OAS) family of enzymes are interferon-inducible antiviral proteins, which synthesize the secondary messenger 2'-5'-linked oligoadenosine (2-5A) in response to viral infection. The production of 2-5As induces RNA decay within the infected cells, thereby effectively preventing further vira...

journal_title：Cytokine

authors： Wang Y,Holleufer A,Gad HH,Hartmann R

更新日期：2020-02-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:Dendritic cell-based vaccines are considered as a new and promising immunotherapeutic approach for cancer treatment. However, the choice of optimal protocol of dendritic cell generation in vitro represents the major challenge. Here, we compared phenotype and functional characteristics of human monocyte-derived dendrit...

journal_title：Cytokine

authors： Leplina OY,Tyrinova TV,Tikhonova MA,Ostanin AA,Chernykh ER

更新日期：2015-01-01 00:00:00

abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

journal_title：Cytokine

authors： Dowrick PG,Prescott AR,Warn RM

更新日期：1991-07-01 00:00:00

abstract：:Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6A writers and can be reversed by proteins that act as m6A erasers. The RNA...

journal_title：Cytokine

authors： Chang G,Leu JS,Ma L,Xie K,Huang S

更新日期：2019-06-01 00:00:00

abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

journal_title：Cytokine

authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

更新日期：2013-01-01 00:00:00

abstract：:Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild-type (WT) white adipose tissue (WAT) into ob/ob mice could mimic the effect of recombinant leptin administration in normaliz...

journal_title：Cytokine

authors： Sennello JA,Fayad R,Pini M,Gove ME,Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...

journal_title：Cytokine

authors： Pancholi S,Earle KA

更新日期：2000-09-01 00:00:00

abstract：:The regulation of macrophage lipoprotein lipase (LPL) by cytokines is potentially of crucial importance in the pathogenesis of atherosclerosis and in septic shock. The effect of combinations of lipopolysaccharide (LPS) and cytokines on the expression of LPL in macrophages was studied using the murine J774.2 cell line....

journal_title：Cytokine

authors： Tengku-Muhammad TS,Hughes TR,Cryer A,Ramji DP

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:This work is focused on finding new markers that complement or diagnoses currently used towards improving knowledge histological and statistical aspects that allow us to predict the local stage carcinomas and to identify and understand all the factors related to the progression of this disease. MATERIALS AN...

journal_title：Cytokine

authors： Torrealba N,Rodríguez-Berriguete G,Fraile B,Olmedilla G,Martínez-Onsurbe P,Guil-Cid M,Paniagua R,Royuela M

更新日期：2017-01-01 00:00:00

abstract：:The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

journal_title：Cytokine

authors： Baumgartner R,Forteza MJ,Ketelhuth DFJ

更新日期：2019-10-01 00:00:00