Interleukin-7 augments CD8+ T cells function and promotes viral clearance in chronic hepatitis C virus infection.

abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

journal_title：Cytokine

authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

更新日期：2013-10-01 00:00:00

abstract：:The predominant pathological features in the central nervous system (CNS) in multiple sclerosis (MS) are perivascular inflammation and demyelination. The cells in the inflammatory cuff consist mainly of T lymphocytes and macrophages. Cytokines produced by inflammatory cells within the CNS have the potential to enhance...

journal_title：Cytokine

authors： Woodroofe MN,Cuzner ML

更新日期：1993-11-01 00:00:00

abstract：:The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...

journal_title：Cytokine

authors： Garama DJ,White CL,Balic JJ,Gough DJ

更新日期：2016-11-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...

journal_title：Cytokine

authors： Galloway C,Chattopadhyay M

更新日期：2013-07-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...

journal_title：Cytokine

authors： Dizdar O,Kalyoncu U,Karadag O,Akdogan A,Kiraz S,Ertenli I,Barista I,Calguneri M

更新日期：2007-01-01 00:00:00

abstract：:Radiation exposure results in an inflammatory reaction with acute as well as subacute consequences. Leukocyte infiltration is one of the predominant early histological changes and involves both cytokines and adhesion molecules. Endothelial cells play a key role in this reaction. We have previously shown the increased ...

journal_title：Cytokine

authors： Van Der Meeren A,Squiban C,Gourmelon P,Lafont H,Gaugler MH

更新日期：1999-11-01 00:00:00

abstract：:Growth related oncogene protein-alpha (GRO-alpha) is a member of C-X-C chemokine and plays an important role in inflammatory responses. Expression of GRO gene family is regulated by a number of factors at both transcriptional and posttranscriptional levels. In the present study, we have addressed the possible regulati...

journal_title：Cytokine

authors： Shibata T,Imaizumi T,Matsumiya T,Tamo W,Hatakeyama M,Yoshida H,Munakata H,Fukuda I,Satoh K

更新日期：2003-11-07 00:00:00

abstract：:Fetal liver is the main site of haematopoiesis during mid-gestation. The adult liver still provides a favourable environment for extramedullary haematopoiesis. Nevertheless, regulation of liver haematopoiesis by cell-cell contacts or by cytokines remains poorly understood. Recently, we have shown that rat liver epithe...

journal_title：Cytokine

authors： Rialland M,Corlu A,Ilyin G,Cabillic F,Lamy I,Guguen-Guillouzo C

更新日期：2000-07-01 00:00:00

abstract：:Nerve growth factor (NGF), which is a neurotrophic factor, is involved in autoimmune and inflammatory processes. Serum NGF levels were investigated in 131 patients with autoimmune (95 with Graves' disease, of whom 57 had ophthalmopathy, 19 with Hashimoto's thyroiditis) and nonimmune thyroid diseases (17 with toxic nod...

journal_title：Cytokine

authors： Molnár I,Bokk A

更新日期：2006-08-01 00:00:00

abstract：:Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is produced by diverse cell types in response to a variety of stresses including hemorrhage and increased mechanical load. Though only relatively recently discovered, IL-33 has been shown to participate in several pathological...

journal_title：Cytokine

authors： Zhu J,Carver W

更新日期：2012-06-01 00:00:00

abstract：:Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...

journal_title：Cytokine

authors： Geslain R,Uddin S,Liu H,Jiang H,van Besien K,Pan T,Wickrema A

更新日期：2013-01-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...

journal_title：Cytokine

authors： van Rijen HV,van Kempen MJ,Postma S,Jongsma HJ

更新日期：1998-04-01 00:00:00

abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

journal_title：Cytokine

authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

更新日期：2016-12-01 00:00:00

abstract：:In this study we assessed the usefulness of serum Transforming Growth Factor-beta1 (TGF-beta1) and soluble Fas (sFas) in distinguishing liver cirrhosis (LC) with and without hepatocellular carcinoma (HCC) as compared with alpha-fetoprotein (AFP). Serum TGF-beta1 and sFas levels were measured by ELISA in 51 LC patients...

journal_title：Cytokine

authors： Sacco R,Leuci D,Tortorella C,Fiore G,Marinosci F,Schiraldi O,Antonaci S

更新日期：2000-06-01 00:00:00

abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

journal_title：Cytokine

authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

更新日期：1991-07-01 00:00:00

abstract：:In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...

journal_title：Cytokine

authors： Marino VJ,Sterin-Prync AE,Roguin LP

更新日期：2003-04-01 00:00:00

abstract：:Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...

journal_title：Cytokine

authors： Pettipher ER,Salter ED

更新日期：1996-02-01 00:00:00

abstract：:C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...

journal_title：Cytokine

authors： Closhen D,Bender B,Luhmann HJ,Kuhlmann CR

更新日期：2010-05-01 00:00:00

abstract：:This study was designed to compare the effect of Aspirin (AS) and Nimesulide (NM) on renal failure and vascular disorder in streptozotocin (STZ)-induced diabetic rats. Rats were divided into four groups; control, diabetic rats, diabetic rats plus AS and diabetic rats plus NM, which are COX inhibitors. The renal and ao...

journal_title：Cytokine

authors： Yesilot S,Ozer MK,Bayram D,Oncu M,Karabacak HI,Cicek E

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

journal_title：Cytokine

authors： Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

更新日期：2011-09-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim...

journal_title：Cytokine

authors： Yang SL,Xu XJ,Tang YM,Song H,Xu WQ,Zhao FY,Shen DY

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of...

journal_title：Cytokine

authors： D'Angelo G,Marseglia L,Granese R,Di Benedetto A,Giacobbe A,Impellizzeri P,Alibrandi A,Ferro E,Palmara A,Manti S,Arrigo T,Salpietro C,Buonocore G,Reiter RJ,Gitto E

更新日期：2018-08-01 00:00:00

abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

journal_title：Cytokine

authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

更新日期：2013-06-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:Platelet activation and platelet-derived cytokines contribute to the vascular inflammation and increased thrombotic activity known to occur in patients with sickle cell anemia (SCA). CD40 ligand (CD40L), a platelet-associated pro-inflammatory molecule that promotes endothelial cell activation, is elevated in the circu...

journal_title：Cytokine

authors： Garrido VT,Sonzogni L,Mtatiro SN,Costa FF,Conran N,Thein SL

更新日期：2017-09-01 00:00:00

abstract：:In this study two different aspects of tumour necrosis factor alpha (TNF-alpha) and interleukin 1 (IL-1) in locally induced murine streptococcal cell wall arthritis (SCW) were investigated. First, the kinetics and interdependence of TNF-alpha and IL-1 release; and second; their involvement in inflammation and cartilag...

journal_title：Cytokine

authors： Kuiper S,Joosten LA,Bendele AM,Edwards CK 3rd,Arntz OJ,Helsen MM,Van de Loo FA,Van den Berg WB

更新日期：1998-09-01 00:00:00

abstract：:We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...

journal_title：Cytokine

authors： Myrianthefs P,Karatzas S,Venetsanou K,Grouzi E,Evagelopoulou P,Boutzouka E,Fildissis G,Spiliotopoulou I,Baltopoulos G

更新日期：2003-12-21 00:00:00

abstract：BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in...

journal_title：Cytokine

authors： Palud A,Parmentier-Decrucq E,Pastre J,De Freitas Caires N,Lassalle P,Mathieu D

更新日期：2015-06-01 00:00:00