当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients.

Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients.

Abstract：

BACKGROUND:Endothelial injury is recognized to trigger organ failures during the first 48h of septic shock. We evaluate endothelial biomarkers at ICU admission in their ability to predict severity, outcome, and organ failures in septic shock patients. METHODS:This prospective observational pilot study was conducted in a medical intensive care unit of a university hospital. Plasma levels of endothelial biomarkers as angiopoietin-2, sE-selectin or endocan were measured at ICU admission of 20 patients presenting with septic shock. Clinical and biological data were recorded at inclusion and each day during the first week. RESULTS:Significant correlations were found between angiopoietin-2 and severity scores at Day 1: SAPS2 (r(2)=0.620; p=0.004) and LOD score (r(2)=0.681; p=0.001). The angiopoietin-2 level was significantly higher in patients presenting with organ failure such as hemodynamic, renal or hepatic failure. It correlated with catecholamine infusion dose and was higher in non survivors compared with survivors (33.5 [28.9-51.4] vs. 12.4 [6.4-14.7]ng/ml; p=0.001). In contrast, in that population presenting with septic shock, endocan level at inclusion was not related to any organ failure at inclusion or Day 1 but appeared lower in patients presenting with respiratory failure at Day 3 compared to those who do not (1.9 [0.99-3.1] vs 5.2 [3.1-17.2]ng/ml; p=0.032). The endocan level at inclusion was correlated with the decrease in PaO2/FiO2 ratio at Day 2 (r(2)=0.628; p=0.0004) and Day 3 (r(2)=0.645; p=0.005). Endocan level <2.54ng/ml at admission is predictive of a respiratory failure presence at Day 3. CONCLUSION:In septic shock patients, angiopoietine-2 is related with clinical severity during the first 24h but only endocan is able to predict the presence of respiratory failure at Day 3.

journal_name

Cytokine

journal_title

Cytokine

authors

Palud A,Parmentier-Decrucq E,Pastre J,De Freitas Caires N,Lassalle P,Mathieu D

doi

10.1016/j.cyto.2015.02.013

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

213-8

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(15)00072-1

journal_volume

73

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Co-culture of human monocytes and thyrocytes in bicameral chamber: monocyte-derived IL-1alpha impairs the thyroid epithelial barrier.

    abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0523

    authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

    更新日期：2000-01-01 00:00:00

  • Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice.

    abstract：:Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0706

    authors： Vázquez E,Gil A,García-Olivares E,Rueda R

    更新日期：2000-08-01 00:00:00

  • Kidney and splanchnic handling of interleukin-6 in humans.

    abstract：:Chronic elevation of circulating Interleukin-6 (IL-6) is observed in elderly individuals as well as in several illnesses, including chronic kidney diseases. A number of cells and tissues possess the ability to metabolize significant amounts of IL-6 in vitro. However, information on signals and mechanisms by which IL-6...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.02.015

    authors： Garibotto G,Sofia A,Balbi M,Procopio V,Villaggio B,Tarroni A,Di Martino M,Cappelli V,Gandolfo MT,Valli A,Verzola D

    更新日期：2007-01-01 00:00:00

  • Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct.

    abstract：:This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.008

    authors： Hokari M,Kuroda S,Chiba Y,Maruichi K,Iwasaki Y

    更新日期：2009-05-01 00:00:00

  • Direct contact with stimulated T cells induces the expression of IL-1beta and IL-1 receptor antagonist in human monocytes. Involvement of serine/threonine phosphatases in differential regulation.

    abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0191

    authors： Vey E,Dayer JM,Burger D

    更新日期：1997-07-01 00:00:00

  • Combination interleukin-2 and interleukin-12 induces severe gastrointestinal toxicity and epithelial cell apoptosis in mice.

    abstract：:Interleukin 2 (IL-2) and interleukin 12 (IL-12) have potent anti-tumour activity as single agent therapy against several different murine and human tumours. Combining these cytokines may result in improved therapeutic effectiveness, however, the toxicity associated with simultaneous administration is prohibitive. This...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0986

    authors： Kaufman HL,Swartout BG,Hörig H,Lubensky I

    更新日期：2002-01-07 00:00:00

  • Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2.

    abstract：:Tumor necrosis factor-alpha (TNF) is expressed on the cell surface as a transmembrane form (tmTNF), that can be released as a soluble form (solTNF) via proteolytic cleavage. These two types of TNF exert their biological functions by binding to one of two TNF receptors, TNFR1 or TNFR2. However, the biological function ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.11.022

    authors： Shibata H,Abe Y,Yoshioka Y,Nomura T,Sato M,Kayamuro H,Kawara T,Arita S,Furuya T,Nagano K,Yoshikawa T,Kamada H,Tsunoda S,Tsutsumi Y

    更新日期：2010-04-01 00:00:00

  • LPS-induced release of IL-1 beta, IL-6, IL-8, TNF-alpha and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein.

    abstract：:We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90080-9

    authors： Eggesbø JB,Hjermann I,Lund PK,Joø GB,Ovstebø R,Kierulf P

    更新日期：1994-09-01 00:00:00

  • The conundrum of interferon-β non-responsiveness in relapsing-remitting multiple sclerosis.

    abstract：:A series of controlled clinical trials have shown that exogenous interferon-beta (IFN-β) benefits patients with relapsing-remitting multiple sclerosis (RRMS) by reducing relapse rate, disability progression, and the formation of new brain and spinal cord lesions on magnetic resonance imaging (MRI) scans. Unfortunately...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.004

    authors： Huber AK,Duncker PC,Irani DN

    更新日期：2015-08-01 00:00:00

  • Molecular identification and immunological characteristics of goose suppressor of cytokine signaling 1 (SOCS-1) in vitro and vivo following DTMUV challenge.

    abstract：:Purpose suppressor of cytokine signaling 1 (SOCS-1) is inducible feedback inhibitors of cytokine signaling and involved in viral infection through regulation of both innate and adaptive immunity. In this study, we firstly cloned SOCS-1 (goSOCS-1) from duck Tembusu virus (DTMUV) infected goose. The full-length sequence...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.03.015

    authors： Zhang W,Chen S,Zhang J,Wu Z,Wang M,Jia R,Zhu D,Liu M,Sun K,Yang Q,Wu Y,Chen X,Cheng A

    更新日期：2017-05-01 00:00:00

  • Production and regulation of interleukin-1 family cytokines at the materno-fetal interface.

    abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.07.005

    authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

    更新日期：2017-11-01 00:00:00

  • Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe).

    abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine having primarily anti-apoptotic and anti-inflammatory effects. Recent reports have documented that IL-6 plays a key role in liver regeneration. Intracellular deficiency of S-adenosylmethionine (SAMe) is a hallmark of toxin-induced liver injury. Although the administra...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.08.004

    authors： Song Z,Chen T,Deaciuc IV,Uriarte S,Hill D,Barve S,McClain CJ

    更新日期：2004-12-21 00:00:00

  • Extensive serum biomarker analysis in patients with nasopharyngeal carcinoma.

    abstract：:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC pati...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.04.031

    authors： Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan C

    更新日期：2019-06-01 00:00:00

  • Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status.

    abstract：UNLABELLED:Hyperoxia exposure can inhibit alveolar growth in the neonatal lung through induction of p21/p53 pathways and is a risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. We previously found that activation of nuclear factor erythroid 2 p45-related factor (Nrf2) improved survi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.09.021

    authors： McGrath-Morrow SA,Lauer T,Collaco JM,Lopez A,Malhotra D,Alekseyev YO,Neptune E,Wise R,Biswal S

    更新日期：2014-01-01 00:00:00

  • An antibody for macrophage migration inhibitory factor suppresses tumour growth and inhibits tumour-associated angiogenesis.

    abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0562

    authors： Ogawa H,Nishihira J,Sato Y,Kondo M,Takahashi N,Oshima T,Todo S

    更新日期：2000-04-01 00:00:00

  • Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.

    abstract：:Chemokines are small chemoattractant cytokines involved in normal and pathological immune processes. Although extensive nucleotide sequence data are available for human and murine chemokine cDNA sequences, very few data are currently available regarding rhesus macaque sequences. To increase our understanding of immune...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.0875

    authors： Basu S,Schaefer TM,Ghosh M,Fuller CL,Reinhart TA

    更新日期：2002-05-07 00:00:00

  • Implication of STAT1 and STAT3 transcription factors in the response to superantigens.

    abstract：:The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.09.006

    authors： Plaza R,Vidal S,Rodriguez-Sanchez JL,Juarez C

    更新日期：2004-01-07 00:00:00

  • The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro

    abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0092

    authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

    更新日期：1996-09-01 00:00:00

  • The treatment of propofol induced the TGF-β1 expression in human endothelial cells to suppress endocytosis activities of monocytes.

    abstract：:Propofol anesthesia and sedation are known to downregulate the functions of many hematopoietic cells, such as macrophages and neutrophils, in vivo. However, the effects of propofol on secretion of the regulatory cytokine transforming growth factor β1 (TGF-β1) in vivo are unknown. In this study, the effects of propofol...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.08.001

    authors： Li CH,Lee RP,Lin YL,Lin CS,Hsu BG,Tseng FJ,Chen YC,Liao KW,Yang FL

    更新日期：2010-12-01 00:00:00

  • Multi-vitamin supplementation blunts the circulating IL-6/IL-10 ratio increase after knee arthroplasty: A randomized, double-blind, placebo controlled study.

    abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2021.155435

    authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

    更新日期：2021-01-23 00:00:00

  • Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.

    abstract：:We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to conta...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.0873

    authors： Kumar S,Hanning CR,Brigham-Burke MR,Rieman DJ,Lehr R,Khandekar S,Kirkpatrick RB,Scott GF,Lee JC,Lynch FJ,Gao W,Gambotto A,Lotze MT

    更新日期：2002-04-21 00:00:00

  • Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies.

    abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.05.022

    authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

    更新日期：2015-12-01 00:00:00

  • Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis.

    abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2016.08.030

    authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

    更新日期：2016-12-01 00:00:00

  • Chronic inflammation and hemodialysis reduce immune competence of peripheral blood leukocytes in end-stage renal failure patients.

    abstract：:Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.12.011

    authors： Knerr K,Füth R,Hemsen P,Mohné W,Heinig A,Kleophas W,Scherbaum WA,Martin S

    更新日期：2005-05-07 00:00:00

  • Biological activity of ovine IL-23 expressed using a foot-and-mouth disease virus 2A self-cleaving peptide.

    abstract：:Hetero-dimeric cytokines often require equi-molar expression of both subunits to achieve biological activity. Previously, we expressed ovine IL-12 p40 and p35 linked using a self-cleaving 2A peptide from foot-and-mouth disease virus (FMDV). We now generated a new improved vector for the expression of hetero-dimeric cy...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.01.014

    authors： Yen HH,Scheerlinck JP

    更新日期：2013-03-01 00:00:00

  • Tumour necrosis factor and interleukin 10 in blood pressure regulation in spontaneously hypertensive and normotensive rats.

    abstract：INTRODUCTION:A growing body of evidence indicates that brain cytokines are involved in the control of the cardiovascular system. Tumour necrosis factor (TNF) is an archetypal cytokine, which exerts its proinflammatory actions via type 1 receptor (TNFR1). Interleukin 10 (IL-10) plays a critical anti-inflammatory role by...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.07.003

    authors： Segiet A,Smykiewicz P,Kwiatkowski P,Żera T

    更新日期：2019-01-01 00:00:00

  • Altered chemokine receptor expression in the peripheral blood lymphocytes in polymyositis and dermatomyositis.

    abstract：OBJECTIVE:To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS:We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4+ or CD8+ lymphocytes. Enzyme linked i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.08.018

    authors： Zhu Z,Yang C,Wang J,Feng Q,Chen Q,Yang P

    更新日期：2017-11-01 00:00:00

  • Relationship between interleukin-17A and isolated coronary ectasia.

    abstract：:The aim of this study was to evaluate serum interleukin (IL)-17A levels in patients with coronary artery ectasia (CAE), the relationship between IL and 17A and CAE, and to determine the relationship between the severity of coronary ectasia and the level of IL-17A. In total, 41 patients (19 female and 22 male) with isc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.11.015

    authors： Uygun T,Demir B,Tosun V,Ungan İ,Kural A,Çiftçi R,Fatullayev F

    更新日期：2019-03-01 00:00:00

  • The chemokine C10: immunological and functional analysis of the sequence encoded by the novel second exon.

    abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0060

    authors： Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

    更新日期：1996-06-01 00:00:00

  • Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migration.

    abstract：:Vascular cell adhesion molecule-1 (VCAM-1) activates endothelial cell NADPH oxidase which catalyzes production of reactive oxygen species (ROS). This activity is required for VCAM-1-dependent lymphocyte migration. The focus of our study was to determine whether these VCAM-1-dependent functions are modulated by cytokin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0922

    authors： Tudor KS,Hess KL,Cook-Mills JM

    更新日期：2001-08-21 00:00:00