Altered chemokine receptor expression in the peripheral blood lymphocytes in polymyositis and dermatomyositis.

abstract：:Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...

journal_title：Cytokine

authors： Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

更新日期：2013-10-01 00:00:00

abstract：:Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to ...

journal_title：Cytokine

authors： El-Asmi F,McManus FP,Brantis-de-Carvalho CE,Valle-Casuso JC,Thibault P,Chelbi-Alix MK

更新日期：2020-05-01 00:00:00

abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：:Azidothymidine (AZT)-induced anemia in mice can be reversed by the administration of IGF-IL-3 (fusion protein of insulin-like growth factor II (IGF II) and interleukin 3). Although interleukin 3 (IL-3) and erythropoietin (EPO) are known to act synergistically on hematopoietic cell proliferation in vitro, injection of ...

journal_title：Cytokine

authors： DiFalco MR,Congote LF

更新日期：2002-04-07 00:00:00

abstract：:We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...

journal_title：Cytokine

authors： Eggesbø JB,Hjermann I,Lund PK,Joø GB,Ovstebø R,Kierulf P

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...

journal_title：Cytokine

authors： Shimodaira T,Matsuda K,Uchibori T,Sugano M,Uehara T,Honda T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Interleukin-35 (IL-35) is a recently described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. The expression of IL-35 in humans is inducible in response to inflammatory stimuli. Increased IL-35 levels were documented in several autoimmune infl...

journal_title：Cytokine

authors： Mann H,Kryštůfková O,Zámečník J,Háček J,Hulejová H,Filková M,Vencovský J,Šenolt L

更新日期：2021-01-01 00:00:00

abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

journal_title：Cytokine

authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

更新日期：2019-04-01 00:00:00

abstract：:Radiation exposure results in an inflammatory reaction with acute as well as subacute consequences. Leukocyte infiltration is one of the predominant early histological changes and involves both cytokines and adhesion molecules. Endothelial cells play a key role in this reaction. We have previously shown the increased ...

journal_title：Cytokine

authors： Van Der Meeren A,Squiban C,Gourmelon P,Lafont H,Gaugler MH

更新日期：1999-11-01 00:00:00

abstract：:Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...

journal_title：Cytokine

authors： Maheshwari A,Voitenok NN,Akalovich S,Shaik SS,Randolph DA,Sims B,Patel RP,Killingsworth CR,Fallon MB,Ohls RK

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...

journal_title：Cytokine

authors： Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

更新日期：2021-02-01 00:00:00

abstract：:We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...

journal_title：Cytokine

authors： Nibali L,D'Aiuto F,Donos N,Griffiths GS,Parkar M,Tonetti MS,Humphries SE,Brett PM

更新日期：2009-01-01 00:00:00

abstract：:Most infections occur in early life, prompting development of novel adjuvanted vaccines to protect newborns and infants. Several Toll-like receptor (TLR) agonists (TLRAs) are components of licensed vaccine formulations or are in development as candidate adjuvants. However, the type and magnitude of immune responses to...

journal_title：Cytokine

authors： van Haren SD,Ganapathi L,Bergelson I,Dowling DJ,Banks M,Samuels RC,Reed SG,Marshall JD,Levy O

更新日期：2016-07-01 00:00:00

abstract：:The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 c...

journal_title：Cytokine

authors： Pranzatelli MR,Tate ED,Travelstead AL,Verhulst SJ

更新日期：2011-03-01 00:00:00

abstract：:Interleukin-1α (IL-1α) and Annexin A2 (AnxA2) are pleiotropic molecules with both intracellular and extracellular roles. They share several characteristics including unconventional secretion aided by S100 proteins, anchoring of the externalized proteins at the outer surface of the plasma membrane and response to oxida...

journal_title：Cytokine

authors： Novák J,Vopálenský V,Pospíšek M,Vedeler A

更新日期：2020-09-01 00:00:00

abstract：:To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistoc...

journal_title：Cytokine

authors： Tournadre A,Porcherot M,Chérin P,Marie I,Hachulla E,Miossec P

更新日期：2009-06-01 00:00:00

abstract：:Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...

journal_title：Cytokine

authors： Pradeep Yeola A,Akbar I,Baillargeon J,Mercy Ignatius Arokia Doss P,Paavilainen VO,Rangachari M

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...

journal_title：Cytokine

authors： de Lima VC,de Carvalho AF,Morato-Marques M,Hashimoto VL,Spilborghs GM,Marques SM,Landman G,Torres C,Braga Ribeiro K,Brentani H,Reis LF,Dias AA

更新日期：2013-05-01 00:00:00

abstract：:Within the human TNF promoter we have identified two sites at positions -189 and -101 that show C/EBP specific binding of nuclear proteins from cells of the human monocytic line Mono Mac 6. Supershift analysis with anti C/EBP antibodies revealed that the complexes formed consist of both C/EBP alpha and C/EBP beta. Whe...

journal_title：Cytokine

authors： Wedel A,Sulski G,Ziegler-Heitbrock HW

更新日期：1996-05-01 00:00:00

abstract：:Interleukin (IL)-7 is a potent proliferation, activation, and survival cytokine for CD8+ T cells to improve viral and tumor specific CD8+ T cell responses. However, the role of IL-7 in regulation of dysfunctional hepatitis C virus (HCV)-specific CD8+ T cells was not fully elucidated. Thus, a total of 53 patients with ...

journal_title：Cytokine

authors： Hou H,Kang Y,Zeng Y,Li Y,Shang J

更新日期：2018-02-01 00:00:00

abstract：:The clinical spectrum of leishmaniasis depends on several factors, including Leishmania species and immunogenetic factors. Tumor necrosis factor α (TNFα) plays a central role in immunity against intracellular infections. Many studies have reported that TNFα-308G > A polymorphism is associated with susceptibility to in...

journal_title：Cytokine

authors： Ejghal R,Charoute H,Talimi H,Rhazlane S,Lemrani M

更新日期：2021-01-24 00:00:00

abstract：:Parasites of the genus Leishmania cause the disease leishmaniasis. As the sandfly vector transfers the promastigotes into the skin of the human host, the infection is either cured or exacerbated. In the process, there emerge several unsolved paradoxes of leishmaniasis. Chronologically, as the infections starts in skin...

journal_title：Cytokine

authors： Saha B,Bhattacharjee S,Sarkar A,Bhor R,Pai K,Bodhale N

更新日期：2020-09-29 00:00:00

abstract：:Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify keratinocyte genes regulated by IL-4 that may play important roles in the pathophysiology of AD. HaCat c...

journal_title：Cytokine

authors： Bao L,Shi VY,Chan LS

更新日期：2013-02-01 00:00:00

abstract：:An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...

journal_title：Cytokine

authors： Guerriero E,Capone F,Rusolo F,Colonna G,Castello G,Costantini S

更新日期：2013-11-01 00:00:00

abstract：:Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...

journal_title：Cytokine

authors： Krychtiuk KA,Stojkovic S,Lenz M,Brekalo M,Huber K,Wojta J,Heinz G,Demyanets S,Speidl WS

更新日期：2018-03-01 00:00:00

abstract：:Thrombopoietin (TPO) plays a pivotal role in megakaryopoiesis. TPO initiates its biological effects by binding to its receptor Mpl. A recombinant protein consisting of a carrier Fc domain linked to multiple Mpl-binding domains was constructed, and is called AMG531. To define the biological activity of AMG531, we exami...

journal_title：Cytokine

authors： Broudy VC,Lin NL

更新日期：2004-01-21 00:00:00

abstract：:Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...

journal_title：Cytokine

authors： Huang M,Chen Q,Xiao J,Zhao X,Liu C

更新日期：2012-04-01 00:00:00

abstract：:Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two...

journal_title：Cytokine

authors： Netea SA,Janssen SA,Jaeger M,Jansen T,Jacobs L,Miller-Tomaszewska G,Plantinga TS,Netea MG,Joosten LA

更新日期：2013-04-01 00:00:00

abstract：:iNKT cells, CD1d dependent natural killer T cells are a unique population of T cells. The capacity of iNKT cells to produce regulatory cytokines first provided an indication of their regulatory potential. Later on, in experimental models as well as in patients afflicted with an auto-immune disease, such as Type 1 diab...

journal_title：Cytokine

authors： Novak J,Lehuen A

更新日期：2011-03-01 00:00:00

abstract：:Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...

journal_title：Cytokine

authors： Oishi K,Hayamizu K,Aihaiti X,Itamoto T,Arihiro K,Asahara T

更新日期：2006-04-01 00:00:00