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Chocolate consumption modulates cytokine production in healthy individuals.

Abstract：

:Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two microorganisms involved in the pathogenesis of acne. In contrast, production of the Th17-derived cytokine IL-22 was inhibited by chocolate. Modulation of inflammation could represent an important mechanism through which chocolate consumption influences acne.

journal_name

Cytokine

journal_title

Cytokine

authors

Netea SA,Janssen SA,Jaeger M,Jansen T,Jacobs L,Miller-Tomaszewska G,Plantinga TS,Netea MG,Joosten LA

doi

10.1016/j.cyto.2013.02.003

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

40-3

issue

1

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(13)00054-9

journal_volume

62

pub_type

临床试验,杂志文章

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