Abstract:
AIMS:This study investigates the relationships between matrix metalloproteinases, inflammations mediators and type 2 diabetes mellitus in Tunisians metabolic syndrome (Mets) patients. METHODS:The study has included 239 MetS patients and 247 controls. Mets was defined according to the NCEP-ATPIII report. Mets patients were also divided into two categories: 29 MetS non-diabetics and 210 MetS diabetics. Dysglycemia markers, matrix metalloproteinase-9 (MMP-9), Tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2), tumor necrosis factor α (TNF-α), C-reactive protein (CRP) levels and White Blood Cells (WBC) counts were determined in patients and controls. RESULTS:In our study, the level of inflammatory markers WBC, TNF-α and matrix metalloproteinases (MMP-8 and MMP-9) were significantly higher in diabetic patients with MetS, as compared with non-diabetic MetS patients. Inflammation mediators and MMP-9 were significantly associated with many clinical characteristics of MetS. The use of ROC "Receiver Operating Characteristic" analysis revealed the impact of TNF alpha on diabetes patients with MetS. In fact TNF alpha was found as a sensitive parameter in these patients with a sensitivity of 85%. CONCLUSION:Inflammation, matrix metalloproteinases and dysglycemia markers are not expressed in isolation but rather concurrently and are continuously interacting with each other, in MetS and diabetics patients. These markers fit with an early stage of cardiovascular disease (CVD); and measuring them could improve the risk evaluation, an early diagnosis, and the prognosis of CVD.
journal_name
Cytokinejournal_title
Cytokineauthors
Zayani Y,El Golli N,Zidi W,Guizani I,Boussairi S,Aloui S,Ayadi I,Ftouhi B,Feki M,Ben Romdhane N,Ben Sliman H,Allal-Elasmi M,Kaabachi Ndoi
10.1016/j.cyto.2016.07.009subject
Has Abstractpub_date
2016-10-01 00:00:00pages
47-52eissn
1043-4666issn
1096-0023pii
S1043-4666(16)30175-2journal_volume
86pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0384
更新日期:1998-12-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.09.012
更新日期:2010-12-01 00:00:00
abstract::Clara cell protein (CC16) is an endogenous anti-inflammatory agent. It is produced mainly in the respiratory and urogenital tracts. CC16 has been quantified in serum, but not in cerebrospinal fluid (CSF). The aim of this study was to examine CSF CC16 in relation to age, gender and serum CC16, and to examine CC16 level...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0318
更新日期:1998-06-01 00:00:00
abstract::IL-4 promotes simultaneous expression of both the CD23 and CD25 antigens in resting human B lymphocytes in a dose-dependent manner. Simultaneous three-colour flow cytometric analysis revealed that CD19+/CD23+/CD25+ triple-positive cells were derived from a CD19+/CD23-/CD25- pool, and that induction of CD23 required lo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0041
更新日期:1996-04-01 00:00:00
abstract::Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90045-7
更新日期:1993-09-01 00:00:00
abstract::Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0466
更新日期:1999-08-01 00:00:00
abstract::Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2016.08.030
更新日期:2016-12-01 00:00:00
abstract::Atherosclerosis is an inflammatory disease of the vasculature regulated by cytokines. Macrophages play a crucial role at all stages of this disease, including regulation of foam cell formation, the inflammatory response and stability of atherosclerotic plaques. For example, matrix metalloproteinases produced by macrop...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.06.315
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:Owing to involvement of host genetic factors in susceptibility to brucellosis infection and its outcome, this study aimed to carry out a comprehensive systematic review and meta-analysis to derive a precise evaluation of the association between the risk of brucellosis and its focal complication and all cytoki...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2019.154949
更新日期:2020-03-01 00:00:00
abstract::There is considerable variability in the concentrations of transforming growth factor beta (TGFbeta) in human milk from individual women which is not readily explained by maternal factors such as smoking or illness. A potential correlate is the maternal plasma level of TGFbeta since changes in plasma concentration of ...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/cyto.2002.0987
更新日期:2002-02-21 00:00:00
abstract::The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.04.003
更新日期:2008-07-01 00:00:00
abstract::This study investigated changes in the myokines IL-1β, IL-6, and TNF-α, as well as HSP72, after endurance training and after a session of downhill running. Twenty-eight rats were allocated to four different groups: 1. Eight weeks of endurance training at 65-70% VO2max (Trained); 2. Endurance training and a single sess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.03.013
更新日期:2015-06-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0233
更新日期:1997-10-01 00:00:00
abstract::Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.11.002
更新日期:2008-02-01 00:00:00
abstract::We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.016
更新日期:2009-01-01 00:00:00
abstract::Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2013.02.003
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) contributes to type 2 diabetes (T2DM) pathogenesis, and genetic variations in VEGFA gene were suggested to influence VEGF secretion and T2DM pathogenesis. AIM:To evaluate the association of specific VEGFA variants with altered VEGF levels, and with T2DM among Tunisi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.003
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.10.007
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.07.023
更新日期:2006-08-01 00:00:00
abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1039
更新日期:2002-07-21 00:00:00
abstract::The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0423
更新日期:1999-03-01 00:00:00
abstract::Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.01.016
更新日期:2015-05-01 00:00:00
abstract::Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.11.010
更新日期:2014-02-01 00:00:00
abstract::Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1989
更新日期:2002-11-07 00:00:00
abstract:INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2005.06.008
更新日期:2005-09-07 00:00:00
abstract::Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.11.006
更新日期:2018-07-01 00:00:00
abstract::We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrat...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0802
更新日期:2001-01-21 00:00:00
abstract::Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.05.020
更新日期:2013-10-01 00:00:00
abstract::The pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) involves an abnormal chemokine regulation. The chemokine receptor CCR4 is necessary for T cell migration to the skin. We, therefore, studied if CCR4 and its ligand macrophage-derived chemokine (MDC/CCL22) could participate in spreading the dis...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.10.005
更新日期:2010-01-01 00:00:00