Abstract:
:We examined the possible alteration of circulating transforming growth factor-beta1 (TGF-beta1) concentrations in a time-dependent fashion in human plasma. Plasma TGF-beta1 was measured three times at 2 week-intervals from each of 12 healthy participants. Platelet factor 4 (PF4) was measured in parallel with TGF-beta1 to estimate the degree of platelet degranulation. TGF-beta1 levels of the second and third plasma samples, in which PF4s were measured as < approximately 1000 IU/ml, were relatively low and fell in a narrow range. However, TGF-beta1 levels of the first samples, in most of which PF4s were > approximately 1000 IU/ml, appeared much higher and more variable than those of the second or third samples. These results indicate that the platelet degranulation accounted for the higher TGF-beta1 levels in the first samples, and thus did not support our initial assumption. We, nevertheless, could propose a useful guidance in the assessment of TGF-beta1 levels in plasma. When the PF4 level is measured as < approximately 1000 IU/ml under our assay conditions, the TGF-beta1 level in a given plasma sample might be accepted as a reliable value considering the effect of platelet degranulation on TGF-beta1 level.
journal_name
Cytokinejournal_title
Cytokineauthors
Jeon JH,Kim YS,Choi EJ,Cheon S,Kim S,Kim JS,Jang JS,Ha WS,Park ST,Park CS,Park K,Park BKdoi
10.1006/cyto.2001.0895keywords:
subject
Has Abstractpub_date
2001-11-07 00:00:00pages
102-5issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(01)90895-6journal_volume
16pub_type
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