Interleukin-7 enhances anti-tumor activity of CD8+ T cells in patients with hepatocellular carcinoma.

abstract：:Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a m...

journal_title：Cytokine

authors： Cerretti DP,Poindexter K,Castner BJ,Means G,Copeland NG,Gilbert DJ,Jenkins NA,Black RA,Nelson N

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Dysregulated production of TNF has been implicated in the pathogenesis and severity of inflammatory rheumatic diseases, many of which show age-related increased incidence. Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation o...

journal_title：Cytokine

authors： Gowers IR,Walters K,Kiss-Toth E,Read RC,Duff GW,Wilson AG

更新日期：2011-12-01 00:00:00

abstract：OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...

journal_title：Cytokine

authors： Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith P

更新日期：2011-11-01 00:00:00

abstract：:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...

journal_title：Cytokine

authors： Bartee E,McFadden G

更新日期：2009-09-01 00:00:00

abstract：:Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...

journal_title：Cytokine

authors： Bianchi M,Fantuzzi G,Bertini R,Perin L,Salmona M,Ghezzi P

更新日期：1993-09-01 00:00:00

abstract：:The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...

journal_title：Cytokine

authors： Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

更新日期：1998-07-01 00:00:00

abstract：:We had earlier shown that human foetal epithelial cells (WISH), growth-inhibited by interferon gamma (IFNgamma), were reversibly detained at a point prior to DNA synthesis. In the present study, we determined the window of action of IFNgamma in the G1 phase duration and the exact point of detention of WISH cells in ce...

journal_title：Cytokine

authors： Vashistha S,Patil S,Joshi C,Ajitkumar P

更新日期：2007-02-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:In human interleukin 4(IL-4), the carboxyl and amino termini of the 129 amino acid hormone are close to each other and this region is believed to be important for binding to the IL-4 receptor (IL-4r). We constructed plasmids encoding circularly permuted IL-4 mutants with the peptide Gly-Gly-Asn-Gly-Gly (GGNGG) joining...

journal_title：Cytokine

authors： Kreitman RJ,Puri RK,McPhie P,Pastan I

更新日期：1995-05-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...

journal_title：Cytokine

authors： Hu X,Cui D,Moscinski LC,Zhang X,Maccachero V,Zuckerman KS

更新日期：2007-02-01 00:00:00

abstract：:Interleukin-1beta (IL-1beta) is a pleiotropic cytokine that can induce several cellular signal transduction pathways. Here, we show that IL-1beta can induce cell cycle arrest and differentiation in the human medullary thyroid carcinoma (MTC) cell line, TT. IL-1beta induces cell cycle arrest accompanied by morphologica...

journal_title：Cytokine

authors： Park JI,Strock CJ,Ball DW,Nelkin BD

更新日期：2005-02-07 00:00:00

abstract：:We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...

journal_title：Cytokine

authors： Nagamine T,Kusakabe T,Takada H,Nakazato K,Sakai T,Oikawa M,Satoh T,Arakawa K

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

journal_title：Cytokine

authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

更新日期：2013-10-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF-alpha) plays an important role in orchestrating inflammatory responses with the vascular endothelium as main target cell type, and was found to promote migration of endothelial cells, as occurs in wound healing processes. Substantial evidence exists that endothelial cell migration in ...

journal_title：Cytokine

authors： van Rijen HV,van Kempen MJ,Postma S,Jongsma HJ

更新日期：1998-04-01 00:00:00

abstract：:Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

journal_title：Cytokine

authors： Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

更新日期：1992-09-01 00:00:00

abstract：:Fifty-five adult patients with primary bone tumour, 27 benign and 28 malignant tumours, were assayed for leukaemia inhibitory factor (LIF) in urine and serum samples. Supernatant was obtained from primary tumour tissue cultures in 24 cases (14 benign, 10 malignant tumours). LIF was found in 11 urine samples (16.7%, 1 ...

journal_title：Cytokine

authors： Gouin F,Heymann D,Raher S,De Groote D,Passuti N,Daculsi G,Godard A

更新日期：1998-02-01 00:00:00

abstract：:The gene polymorphisms interferon-gamma (IFN-gamma) +874 T/A and interleukin (IL)-4 -590 C/T have been associated with the altered production of cytokines. Therefore, they might be indicative of the occurrence of Paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. The analysis of single nucleotide po...

journal_title：Cytokine

authors： Bozzi A,Reis BS,Pereira PP,Pedroso EP,Goes AM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...

journal_title：Cytokine

authors： Shimodaira T,Matsuda K,Uchibori T,Sugano M,Uehara T,Honda T

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

journal_title：Cytokine

authors： Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

更新日期：2013-05-01 00:00:00

abstract：:To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulat...

journal_title：Cytokine

authors： Denizot Y,Karoutsos S,Nathan N

更新日期：2001-03-07 00:00:00

abstract：:Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. Oral epithelial cells are involved in innate immunity against Candida infections via Toll-like receptors (TLRs) and inflammatory mediators. We investig...

journal_title：Cytokine

authors： Décanis N,Savignac K,Rouabhia M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Interleukin-35 (IL-35) is a recently described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. The expression of IL-35 in humans is inducible in response to inflammatory stimuli. Increased IL-35 levels were documented in several autoimmune infl...

journal_title：Cytokine

authors： Mann H,Kryštůfková O,Zámečník J,Háček J,Hulejová H,Filková M,Vencovský J,Šenolt L

更新日期：2021-01-01 00:00:00

abstract：:Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...

journal_title：Cytokine

authors： Vázquez E,Gil A,García-Olivares E,Rueda R

更新日期：2000-08-01 00:00:00

abstract：:Elevated levels of the cytokine IL-13 has been found to be associated with autoimmune diseases, including Sjögren's Syndrome. However, whether IL-13 plays a causative role in disease development is not known and cannot be easily studied in humans. Our previous work has shown that levels of IL-13 are elevated in Id3 kn...

journal_title：Cytokine

authors： Belle I,Mahlios J,McKenzie A,Zhuang Y

更新日期：2014-10-01 00:00:00

abstract：:There is considerable variability in the concentrations of transforming growth factor beta (TGFbeta) in human milk from individual women which is not readily explained by maternal factors such as smoking or illness. A potential correlate is the maternal plasma level of TGFbeta since changes in plasma concentration of ...

journal_title：Cytokine

authors： Hawkes JS,Bryan DL,Gibson RA

更新日期：2002-02-21 00:00:00

abstract：:Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...

journal_title：Cytokine

authors： Zaibi MS,Kępczyńska MA,Harikumar P,Alomar SY,Trayhurn P

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...

journal_title：Cytokine

authors： Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

更新日期：2020-12-01 00:00:00

abstract：:Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented s...

journal_title：Cytokine

authors： Cai D,Xu Y,Ding R,Qiu K,Zhang R,Wang H,Huang L,Xie X,Yan H,Deng Y,Lin X,Shao J,Luo X,Duan C

更新日期：2020-02-01 00:00:00

abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

journal_title：Cytokine

authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

更新日期：2018-11-01 00:00:00

abstract：:Although physical therapy has been shown to be an effective method for treatment of rheumatoid arthritis, a thorough investigation on the impact of mechanical signals upon the complex cytokine network associated with pathogenesis has not yet been conducted. In the current study, our research group investigated the eff...

journal_title：Cytokine

authors： Bader RA,Wagoner KL

更新日期：2010-07-01 00:00:00