Abstract：
:The gene polymorphisms interferon-gamma (IFN-gamma) +874 T/A and interleukin (IL)-4 -590 C/T have been associated with the altered production of cytokines. Therefore, they might be indicative of the occurrence of Paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. The analysis of single nucleotide polymorphism (SNP) at position+874 IFN-gamma showed an increase occurrence of A/T genotype in both PCM patients and healthy individuals as control (HIC) (56% and 45%, respectively), while the allelic distribution showed 82% of A allele in the patients and 80% in the controls. The SNP of -590 IL-4 showed that C/T genotype was significantly (p<0.05) more prevalent (39%) in PCM group compared to the HIC group (19%), while IL-4 C/C genotype was significantly less frequent (59%) in the patient group compared to the control group (81%). Otherwise, 41% of PCM patients and 19% of HIC individuals carried the IL-4 T allele. Stimulation of peripheral blood mononuclear cells (PBMC) from PCM patients with cell extract antigenic preparations (PbAg) as well as secreted and surface antigens (MEXO) of P. brasiliensis evidenced that there is no difference in the IFN-gamma production related to A and T alleles between PCM and HIC individuals. However, with IL-4 production, PCM patients classified as C phenotype showed two times more IL-4 production than PCM patients classified as T phenotype and HIC controls. In conclusion, our results suggest that functional genetic variants in the IL-4 promoter could influence the production of IL-4 in PCM.
journal_name
Cytokinejournal_title
Cytokineauthors
Bozzi A,Reis BS,Pereira PP,Pedroso EP,Goes AMdoi
10.1016/j.cyto.2009.07.011subject
Has Abstractpub_date
2009-12-01 00:00:00pages
212-7issue
3eissn
1043-4666issn
1096-0023pii
S1043-4666(09)00195-1journal_volume
48pub_type
杂志文章相关文献
CYTOKINE文献大全abstract：BACKGROUND:Dysregulated production of TNF has been implicated in the pathogenesis and severity of inflammatory rheumatic diseases, many of which show age-related increased incidence. Ageing is also associated with changes in the immune system including higher systemic levels of pro-inflammatory cytokines. Methylation o...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2011.09.009
更新日期：2011-12-01 00:00:00
abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2002.2004
更新日期：2002-12-07 00:00:00
abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.05.004
更新日期：2007-05-01 00:00:00
abstract：:Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2000.0710
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2011.06.023
更新日期：2011-11-01 00:00:00
abstract：:We have studied the effects of rhTGF-beta2, dexamethanosome (dex) and 1,25(OH)2D3 on human bone marrow stromal (HBMS) cells in long-term culture. A fraction on HBMS expressed type I collagen (Col I) and osteopontin, and transient treatment (48 h) with dex increased the number of alkaline phosphatase (ALP) positive cel...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1997.0209
更新日期：1997-08-01 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF) is expressed on the cell surface as a transmembrane form (tmTNF), that can be released as a soluble form (solTNF) via proteolytic cleavage. These two types of TNF exert their biological functions by binding to one of two TNF receptors, TNFR1 or TNFR2. However, the biological function ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2009.11.022
更新日期：2010-04-01 00:00:00
abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.11.017
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:Mycoplasma pneumoniae (M. pneumoniae) is a common causative agent of pneumonia in children. The aim of this study is to determine whether there is any difference in selected cytokine or chemokines response in asthmatic children compared to non-asthmatic children during acute M. pneumoniae pneumonia. METHODS:Se...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2011.02.008
更新日期：2011-05-01 00:00:00
abstract：:Adiponectin, the most prevalent adipo-cytokine in plasma plays critical metabolic and anti-inflammatory roles is fast emerging as an important molecular target for the treatment of metabolic disorders. Adiponectin action is critical in multiple organs including cardio-vascular system, muscle, liver, adipose tissue, br...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2018.06.012
更新日期：2018-12-01 00:00:00
abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.06.009
更新日期：2010-09-01 00:00:00
abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2019.154931
更新日期：2020-03-01 00:00:00
abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.04.004
更新日期：2010-07-01 00:00:00
abstract：:Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and ...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2015.07.014
更新日期：2015-12-01 00:00:00
abstract：:The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation. ...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2015.03.001
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Associations between polymorphisms in interleukins and breast cancer (BC) were already investigated by many studies, yet with controversial findings. The aim of this meta-analysis was to better clarify associations between polymorphisms in interleukins and BC by combing the results of all relevant articles. ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.154988
更新日期：2020-03-09 00:00:00
abstract：:The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...
journal_title：Cytokine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cyto.2009.10.002
更新日期：2010-01-01 00:00:00
abstract：INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...
journal_title：Cytokine
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cyto.2009.01.001
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.09.011
更新日期：2007-12-01 00:00:00
abstract：:Functional diversity of the memory T-cell-derived cytokine IL-17 was explored at the receptor level. IL-17 inhibited TNF-induced chemokine Rantes expression in human synovial fibroblasts and mouse lung fibroblasts. This inhibitory activity of IL-17 (IC50=0.2 ng/ml) was 6-fold more potent than its stimulatory activity ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2005.02.012
更新日期：2005-08-07 00:00:00
abstract：:Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2013.05.020
更新日期：2013-10-01 00:00:00
abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2018.12.012
更新日期：2019-04-01 00:00:00
abstract：:The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15Ralpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed ...
journal_title：Cytokine
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cyto.2008.04.008
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody was significantly associated with dermatomyositis associated with interstitial lung disease (DM-ILD) and poor survival in patients. However, there was no convenient and accurate biomarker can predict the poor prognosis of anti-MDA5 posi...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155209
更新日期：2020-11-01 00:00:00
abstract：:This study was aimed to evaluate the effects on some inflammatory markers of two dialytic treatments [bicarbonate dialysis (BHD) and hemodiafiltration (HDF)] in patients with severe chronic kidney disease. We evaluated: blood glucose, homeostasis model assessment insulin resistance index, homocistein (Hcs), high sensi...
journal_title：Cytokine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.cyto.2016.12.026
更新日期：2017-04-01 00:00:00
abstract：:This moleculo-epidemiological and immunological study through cytokine response assessment was done to know the dynamics of cytokines in the initiation, persistence and association to physiological changes of a particular pathogen in water buffaloes. This is important to understand the magnitude and behavior of diseas...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2009.02.006
更新日期：2009-05-01 00:00:00
abstract：:Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2005.06.004
更新日期：2005-09-07 00:00:00
abstract：:In serum-free WEHI-3 supernatants an activity was detected inducing haemoglobin synthesis in human and murine erythroleukaemia cell lines. The absolute numbers of benzidine-positive cells induced with either DMSO or WEHI-3-conditioned medium were comparable. Terminal differentiation was not observed. An expression lib...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2004.02.005
更新日期：2004-06-21 00:00:00
abstract：:LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells) is a recently identified of the tumor necrosis factor alpha (TNF-alpha) ligand superfamily. We wanted to establish whether the presence of chronic viral hepatitis could be implicated in enhanc...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.07.189
更新日期：2007-09-01 00:00:00
abstract：:In order to understand the cellular disease mechanisms of osteoarthritic cartilage degeneration it is of primary importance to understand both the anabolic and the catabolic processes going on in parallel in the diseased tissue. In this study, we have applied cDNA-array technology (Clontech) to study gene expression p...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2005.04.009
更新日期：2005-08-07 00:00:00
