Abstract:
OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical parameters of bone turnover and mineral metabolism as well as routine haematological and biochemical parameters were measured. Clinical data were recorded prospectively. RESULTS:In multivariate analysis cervical HF (OR=1.81; 95% CI 1.05-3.11), diabetes (OR=2.60; 95% CI 1.23-5.51) and history of stroke (OR=2.67; 95% CI 1.17-6.13) were significant independent predictors of higher resistin levels (≥16.26 ng/ml, median value). The independent correlates of serum resistin levels in patients with cervical HF were serum osteocalcin and magnesium (both negatively associated) and in patients with trochanteric HF, serum PTH, calcium and age (all positively associated). Resistin and glomerular filtration rate were the only independent (inverse) predictors of serum osteocalcin. Resistin levels on admission did not predict short-term outcomes. CONCLUSIONS:In older patients with HF there is a significant association of higher resistin levels with cervical fracture, type 2 diabetes and history of stroke, which is partly influenced by the reciprocal interaction between resistin and osteocalcin. However, the design of the study does not prove causality and further prospective studies are needed to clarify these relationships.
journal_name
Cytokinejournal_title
Cytokineauthors
Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith Pdoi
10.1016/j.cyto.2011.06.023subject
Has Abstractpub_date
2011-11-01 00:00:00pages
157-66issue
2eissn
1043-4666issn
1096-0023pii
S1043-4666(11)00215-8journal_volume
56pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::In this study we assessed the usefulness of serum Transforming Growth Factor-beta1 (TGF-beta1) and soluble Fas (sFas) in distinguishing liver cirrhosis (LC) with and without hepatocellular carcinoma (HCC) as compared with alpha-fetoprotein (AFP). Serum TGF-beta1 and sFas levels were measured by ELISA in 51 LC patients...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0650
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.04.005
更新日期:2015-10-01 00:00:00
abstract::Staphylococcus aureus is one of the versatile Gram positive bacteria causing a range of diseases. Upon challenge, host immune cells recognize S. aureus and mount diverse immune responses including production of pro-inflammatory cytokines such as IL-1β and TNF-α. These cytokines are important mediators of inflammation ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.03.007
更新日期:2016-05-01 00:00:00
abstract::Adiponectin, the most prevalent adipo-cytokine in plasma plays critical metabolic and anti-inflammatory roles is fast emerging as an important molecular target for the treatment of metabolic disorders. Adiponectin action is critical in multiple organs including cardio-vascular system, muscle, liver, adipose tissue, br...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2018.06.012
更新日期:2018-12-01 00:00:00
abstract::Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0748
更新日期:2000-10-01 00:00:00
abstract::Interleukin-1α (IL-1α) and Annexin A2 (AnxA2) are pleiotropic molecules with both intracellular and extracellular roles. They share several characteristics including unconventional secretion aided by S100 proteins, anchoring of the externalized proteins at the outer surface of the plasma membrane and response to oxida...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155141
更新日期:2020-09-01 00:00:00
abstract::The clinical spectrum of leishmaniasis depends on several factors, including Leishmania species and immunogenetic factors. Tumor necrosis factor α (TNFα) plays a central role in immunity against intracellular infections. Many studies have reported that TNFα-308G > A polymorphism is associated with susceptibility to in...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2021.155437
更新日期:2021-01-24 00:00:00
abstract::IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.005
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Oxidative stress is involved in several maternal conditions characterized both by an increase in free radicals synthesis and a parallel decrease in the antioxidant activity. Parturition induces considerable oxidative stress and many inflammatory mediators, among which HMGB1, are involved from the beginning of...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.03.019
更新日期:2018-08-01 00:00:00
abstract::Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.06.003
更新日期:2011-11-01 00:00:00
abstract::Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15Ralpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed ...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.cyto.2008.04.008
更新日期:2008-07-01 00:00:00
abstract::Among myriads of distinct chemical modification in RNAs, the dynamic, reversible and fine-tuned methylation of N6-methyladenosine (m6A) is the most prevalent modification in eukaryotic mRNAs. This RNA mark is generated by proteins that act as m6A writers and can be reversed by proteins that act as m6A erasers. The RNA...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2018.06.018
更新日期:2019-06-01 00:00:00
abstract::We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.08.005
更新日期:2003-12-21 00:00:00
abstract::Expression of cytokine genes, TNF-alpha, TNF-beta and IFN-gamma, in human astroglial cell lines and in fresh brain specimens was studied by PCR. mRNA transcripts of TNF-alpha could be detected in three out of five astrocytomas and neuroblastoma cell lines, and after stimulation with IL-1 beta/IFN-gamma or LPS/IFN-gamm...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90039-6
更新日期:1994-03-01 00:00:00
abstract::IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2011.07.006
更新日期:2011-10-01 00:00:00
abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.10.011
更新日期:2012-01-01 00:00:00
abstract:UNLABELLED:Hyperoxia exposure can inhibit alveolar growth in the neonatal lung through induction of p21/p53 pathways and is a risk factor for the development of bronchopulmonary dysplasia (BPD) in preterm infants. We previously found that activation of nuclear factor erythroid 2 p45-related factor (Nrf2) improved survi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.09.021
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155264
更新日期:2020-12-01 00:00:00
abstract::We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/s1043-4666(03)00114-5
更新日期:2003-07-01 00:00:00
abstract::Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.07.039
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.cyto.2009.01.001
更新日期:2009-04-01 00:00:00
abstract::Most infections occur in early life, prompting development of novel adjuvanted vaccines to protect newborns and infants. Several Toll-like receptor (TLR) agonists (TLRAs) are components of licensed vaccine formulations or are in development as candidate adjuvants. However, the type and magnitude of immune responses to...
journal_title:Cytokine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.cyto.2016.04.001
更新日期:2016-07-01 00:00:00
abstract::Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0791
更新日期:2001-01-07 00:00:00
abstract::Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155089
更新日期:2020-07-01 00:00:00
abstract::Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2008.07.015
更新日期:2008-09-01 00:00:00
abstract::We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.06.008
更新日期:2006-06-01 00:00:00
abstract::Despite vaccine efforts, influenza outbreaks pose a significant threat to global public health. There are two commercially available seasonal influenza vaccines in the United States: the trivalent inactivated vaccine (TIV), delivered parenterally, and the live attenuated influenza vaccine (LAIV), delivered intranasall...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.08.004
更新日期:2012-12-01 00:00:00
abstract::Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1006/cyto.2000.0747
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1ß and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. METHODS:Serum levels of IL-31, IL-1ß and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155102
更新日期:2020-07-01 00:00:00