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The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia.

Abstract：

:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflammatory cytokine IL-6 has been postulated to be involved in some ways in the pathogenesis of preeclampsia. However studies investigating whether levels of IL-6 in the maternal circulation differ between the disease severities or between times of onset of preeclampsia, or between preeclamptic pregnancies that are or are not complicated by fetal growth restriction (FGR) are limited. 104 women with preeclampsia and 75 health pregnant women were included into this study. The levels of IL-6 in maternal circulation were measured by enzyme-linked immunosorbent assay (ELISA). The levels of IL-6 in serum were significantly increased in women with preeclampsia in early onset and late onset preeclampsia compared to gestation matched health pregnant women. In addition, the levels of IL-6 were significantly increased in women with severe preeclampsia, but not with mild preeclampsia compared to gestation matched health pregnant women. Furthermore there was no correlation in IL-6 levels between preeclamptic with or without FGR. Our data shows increased level of circulating IL-6 levels in both women with early onset or late onset preeclampsia and in women with severe preeclampsia. These results suggest the excessive maternal inflammatory response in preeclampsia.

journal_name

Cytokine

journal_title

Cytokine

authors

Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

doi

10.1016/j.cyto.2012.07.039

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

856-60

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(12)00637-0

journal_volume

60

pub_type

杂志文章

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