abstract：:The hyper-inflammatory response is thought to be a major cause of acute respiratory distress syndrome (ARDS) in patients with COVID-19. Although multiple cytokines are reportedly associated with disease severity, the key mediators of SARS-CoV-2 induced cytokine storm and their predictive values have not been fully elu...

journal_title：Cytokine

authors： Liu Y,Chen D,Hou J,Li H,Cao D,Guo M,Ling Y,Gao M,Zhou Y,Wan Y,Zhu Z

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Bronchial asthma (BA) is a chronic disease of the airways. The great majority of BA exacerbations are associated with respiratory viral infections. Recent findings point out a possible role of proinflammatory cytokine interleukin-33 (IL-33) in the development of atopic diseases. Although, little is known abo...

journal_title：Cytokine

authors： Nikonova A,Shilovskiy I,Galitskaya M,Sokolova A,Sundukova M,Dmitrieva-Posocco O,Mitin A,Komogorova V,Litvina M,Sharova N,Zhernov Y,Kudlay D,Dvornikov A,Kurbacheva O,Khaitov R,Khaitov M

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

journal_title：Cytokine

authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...

journal_title：Cytokine

authors： Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

更新日期：2021-02-01 00:00:00

abstract：:The evolution of malignant cells implies an increase in oncogenic fitness of cells which arises in active and reciprocal interaction with the tumor microenvironment. The mechanisms facilitating the adaptive evolution of cancer cells involve clonal selection of cancer cells, in a direction of increased adaptive potenti...

journal_title：Cytokine

authors： Todorović-Raković N

更新日期：2021-01-25 00:00:00

abstract：:The clinical spectrum of leishmaniasis depends on several factors, including Leishmania species and immunogenetic factors. Tumor necrosis factor α (TNFα) plays a central role in immunity against intracellular infections. Many studies have reported that TNFα-308G > A polymorphism is associated with susceptibility to in...

journal_title：Cytokine

authors： Ejghal R,Charoute H,Talimi H,Rhazlane S,Lemrani M

更新日期：2021-01-24 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00

abstract：:Visfatin is an important adipokines, which are expressed in different tissues including ovary of mammals. The postnatal ovary in rodents undergoes dramatic changes of intra-ovarian factors in relation to proliferation and apoptosis. There are studies which showed that gonadal visfatin changes in postnatal life. Howeve...

journal_title：Cytokine

authors： Annie L,Gurusubramanian G,Kumar Roy V

更新日期：2021-01-18 00:00:00

abstract：BACKGROUND:The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19. ...

journal_title：Cytokine

authors： Satış H,Özger HS,Aysert Yıldız P,Hızel K,Gulbahar Ö,Erbaş G,Aygencel G,Guzel Tunccan O,Öztürk MA,Dizbay M,Tufan A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Interleukin-35 (IL-35) is a recently described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. The expression of IL-35 in humans is inducible in response to inflammatory stimuli. Increased IL-35 levels were documented in several autoimmune infl...

journal_title：Cytokine

authors： Mann H,Kryštůfková O,Zámečník J,Háček J,Hulejová H,Filková M,Vencovský J,Šenolt L

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Cigarette smoking is a major risk factor for cancer and other diseases. While smoking induces chronic inflammation and aberrant immune responses, the effects of smokeless tobacco products (STPs) on immune responses is less clear. Here we evaluated markers related to immune regulation in smokers (SMK), moist ...

journal_title：Cytokine

authors： Tran QT,Arimilli S,Scott E,Chen P,Prasad GL

更新日期：2021-01-01 00:00:00

abstract：:Although G-CSF mobilized peripheral blood stem cell (PBSC) transplantation is commonly used in adults, bone marrow (BM) is still the preferred stem cell source in pediatric stem cell transplantation. Despite the fact that G-CSF is increasingly being used to enhance the hematopoietic stem/progenitor cell (HSPC) yield i...

journal_title：Cytokine

authors： Aerts-Kaya F,Kilic E,Köse S,Aydin G,Cagnan I,Kuskonmaz B,Uckan-Cetinkaya D

更新日期：2020-12-28 00:00:00

abstract：AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...

journal_title：Cytokine

authors： Xu Y,Wang Y,Ma X,Xiao Y,Wang Y,Bao Y

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...

journal_title：Cytokine

authors： Lin MF,Sun B,Liu ZY,Tang P,Zhang LJ,Wang YY

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...

journal_title：Cytokine

authors： Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...

journal_title：Cytokine

authors： Sakemi R,Mitsuyama K,Morita M,Yoshioka S,Kuwaki K,Tokuyasu H,Fukunaga S,Mori A,Araki T,Yoshimura T,Yamasaki H,Tsuruta K,Morita T,Yamasaki S,Mizoguchi A,Sou S,Torimura T

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effe...

journal_title：Cytokine

authors： Asbaghi O,Yaghubi E,Nazarian B,Kelishadi MR,Khadem H,Moodi V,Naeini F,Ghaedi E

更新日期：2020-12-01 00:00:00

abstract：:Increasing evidence shows that inflammation plays critical roles in the tumorigenesis of bladder cancer. Fibroblast growth factor 12 (FGF12), a kind of inflammatory cytokine, is located in the region of 3q28 that has been demonstrated to be a bladder cancer risk locus by genome wide association study (GWAS). In this s...

journal_title：Cytokine

authors： Wu J,Huang H,Huang Q,Qiu R,Huang M,Meng D

更新日期：2020-12-01 00:00:00

abstract：:Obesity, a chronic low-grade inflammation metabolic abnormality, is related to high proinflammatory cytokines concentrations. Epstein-Barr virus-induced gene 3 (EBI3) encodes for the EBI3 beta subunit that constitutes interleukin (IL) 27 and 35. Our objective was to assess the association of three EBI3 single nucleoti...

journal_title：Cytokine

authors： Posadas-Sánchez R,Del Carmen González-Salazar M,Cardoso-Saldaña G,Andrés Criales-Vera S,Reyes-Barrera J,Pérez-Hernández N,Manuel Fragoso J,Vargas-Alarcón G

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels o...

journal_title：Cytokine

authors： Brys A,Stasio ED,Lenaert B,Picca A,Calvani R,Marzetti E,Gambaro G,Bossola M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody was significantly associated with dermatomyositis associated with interstitial lung disease (DM-ILD) and poor survival in patients. However, there was no convenient and accurate biomarker can predict the poor prognosis of anti-MDA5 posi...

journal_title：Cytokine

authors： Gao Y,Zhao Q,Xie M,Yan X,Li Y,Zhang X,Wu H,Dai J,Cao M,Cai H

更新日期：2020-11-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:Parasites of the genus Leishmania cause the disease leishmaniasis. As the sandfly vector transfers the promastigotes into the skin of the human host, the infection is either cured or exacerbated. In the process, there emerge several unsolved paradoxes of leishmaniasis. Chronologically, as the infections starts in skin...

journal_title：Cytokine

authors： Saha B,Bhattacharjee S,Sarkar A,Bhor R,Pai K,Bodhale N

更新日期：2020-09-29 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants. In spite of the enormous clinical burden caused by RSV infections, there remains no efficacious RSV vaccine. CD8 T cells mediate viral clearance as well as provide protection against a secondary ...

journal_title：Cytokine

authors： Schmidt ME,Varga SM

更新日期：2020-09-01 00:00:00

abstract：:Interleukin-1α (IL-1α) and Annexin A2 (AnxA2) are pleiotropic molecules with both intracellular and extracellular roles. They share several characteristics including unconventional secretion aided by S100 proteins, anchoring of the externalized proteins at the outer surface of the plasma membrane and response to oxida...

journal_title：Cytokine

authors： Novák J,Vopálenský V,Pospíšek M,Vedeler A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Pneumonia is the leading cause of death in children under 5, with the highest burden in resource-limited countries. Endothelial activation occurs in pneumonia and can be assessed using quantitative levels of biomarkers angiopoietin (Ang)-1 and Ang-2. We examined admission levels of Ang-1 and Ang-2 in pediatri...

journal_title：Cytokine

authors： Zhang R,Rai U,Ibrahim NBM,Amazouz Y,Soo J,Conroy AL,Namasopo S,Opoka RO,Bhargava R,Hawkes MT

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

journal_title：Cytokine

authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

更新日期：2020-07-01 00:00:00

abstract：:Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...

journal_title：Cytokine

authors： Falfán-Valencia R,Ramírez-Venegas A,Pérez Lara-Albisua JL,Ramírez-Rodriguez SL,Márquez-García JE,Buendía-Roldan I,Gayosso-Gómez LV,Pérez-Padilla R,Ortiz-Quintero B

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:This case-control study aimed to evaluate the ability to use a panel of IL-31, IL-1ß and NLRP3 to differentiate sepsis from systemic inflammatory response syndrome (SIRS) and to predict septic shock. METHODS:Serum levels of IL-31, IL-1ß and NLRP3 were measured by ELISA in 149 participants; 38 with sepsis, 51 w...

journal_title：Cytokine

authors： Watany MM,Elmazny MI,Nasif EM

更新日期：2020-07-01 00:00:00

abstract：:Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...

journal_title：Cytokine

authors： Pradeep Yeola A,Akbar I,Baillargeon J,Mercy Ignatius Arokia Doss P,Paavilainen VO,Rangachari M

更新日期：2020-05-01 00:00:00

abstract：:Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to ...

journal_title：Cytokine

authors： El-Asmi F,McManus FP,Brantis-de-Carvalho CE,Valle-Casuso JC,Thibault P,Chelbi-Alix MK

更新日期：2020-05-01 00:00:00

abstract：:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...

journal_title：Cytokine

authors： Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat S

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Associations between polymorphisms in interleukins and breast cancer (BC) were already investigated by many studies, yet with controversial findings. The aim of this meta-analysis was to better clarify associations between polymorphisms in interleukins and BC by combing the results of all relevant articles. ...

journal_title：Cytokine

authors： Xu G,Wang F

更新日期：2020-03-09 00:00:00

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...

journal_title：Cytokine

authors： de Rezende MC,Moreira JMP,Fernandes LLM,Rodrigues VF,Negrão-Corrêa D

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Immuno-inflammation plays an important role in the pathophysiological process of sepsis-associated acute hepatic injury (AHI). Interleukin 27 (IL-27) is an important inflammatory regulator; however, its role in this condition is not clear. METHODS:The clinical data and IL-27 serum levels in sepsis patients ...

journal_title：Cytokine

authors： Fan J,Zhang YC,Zheng DF,Zhang M,Liu H,He M,Wu ZJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Owing to involvement of host genetic factors in susceptibility to brucellosis infection and its outcome, this study aimed to carry out a comprehensive systematic review and meta-analysis to derive a precise evaluation of the association between the risk of brucellosis and its focal complication and all cytoki...

journal_title：Cytokine

authors： Zafari P,Zarifian A,Alizadeh-Navaei R,Taghadosi M,Rafiei A

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Inflammatory periodontal diseases are caused by interaction between gram negative, anaerobic bacteria and host response. Persistent infection of Pseudomonas aeruginosa in cystic fibrosis (CF) patients also cause increased pro-inflammatory response and the imbalance of pro- and anti-inflammatory response in b...

journal_title：Cytokine

authors： Duruel O,Berker E,Özşin-Özler C,Gharibzadeh-Hızal M,Gürpınar Ö,Eryılmaz-Polat S,Ataman-Duruel ET,Tan Ç,Karabulut E,Tekçiçek M,Eser ÖK,Kiper N,Tezcan İ

更新日期：2020-03-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...

journal_title：Cytokine

authors： Mao X,Qiu X,Jiao C,Lu M,Zhao X,Li X,Li J,Ma J,Zhang H

更新日期：2020-02-01 00:00:00

abstract：:Lung cancer is a common malignant disease, nearly 2.09 million new patients occurred last year. Approximately 85% of the patients are classified as non-small-cell lung cancer (NSCLC). It is therefore important to identify new diagnostic and prognostic biomarkers for the early detection of this disease. The presented s...

journal_title：Cytokine

authors： Cai D,Xu Y,Ding R,Qiu K,Zhang R,Wang H,Huang L,Xie X,Yan H,Deng Y,Lin X,Shao J,Luo X,Duan C

更新日期：2020-02-01 00:00:00