Abstract:
BACKGROUND:Bronchial asthma (BA) is a chronic disease of the airways. The great majority of BA exacerbations are associated with respiratory viral infections. Recent findings point out a possible role of proinflammatory cytokine interleukin-33 (IL-33) in the development of atopic diseases. Although, little is known about the role of IL-33 in virus-induced BA exacerbations. METHODS:We used mouse models of RSV (respiratory syncytial virus)-induced inflammation exacerbation in OVA-sensitized mice and RSV infection alone in adult animals to characterize expression of il33 in the mouse lungs. Moreover, we studied the influence of il33 knockdown with intranasally administrated siRNA on the development of RSV-induced inflammation exacerbation. In addition, we evaluated the expression of IL33 in the ex vivo stimulated PBMCs from allergic asthma patients and healthy subjects with and without confirmed acute respiratory viral infection. RESULTS:Using mouse models, we found that infection with RSV drives enhanced il33 mRNA expression in the mouse lung. Treatment with anti-il33 siRNA diminishes airway inflammation in the lungs (we found a decrease in the number of inflammatory cells in the lungs and in the severity of histopathological alterations) of mice with RSV-induced inflammation exacerbation, but do not influence viral load. Elevated level of the IL33 mRNA was detected in ex vivo stimulated blood lymphocytes of allergic asthmatics infected with respiratory viruses. RSV and rhinovirus were the most detected viruses in volunteers with symptoms of respiratory infection. CONCLUSION:The present study provides additional evidence of the crucial role of the IL-33 in pathogenesis of RSV infection and virus-induced allergic bronchial asthma exacerbations.
journal_name
Cytokinejournal_title
Cytokineauthors
Nikonova A,Shilovskiy I,Galitskaya M,Sokolova A,Sundukova M,Dmitrieva-Posocco O,Mitin A,Komogorova V,Litvina M,Sharova N,Zhernov Y,Kudlay D,Dvornikov A,Kurbacheva O,Khaitov R,Khaitov Mdoi
10.1016/j.cyto.2020.155349subject
Has Abstractpub_date
2021-02-01 00:00:00pages
155349eissn
1043-4666issn
1096-0023pii
S1043-4666(20)30365-3journal_volume
138pub_type
杂志文章相关文献
CYTOKINE文献大全abstract:BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.04.005
更新日期:2015-10-01 00:00:00
abstract::Tumour necrosis factor (TNF) is a key regulator of inflammation and immunity. The cellular effects exerted by TNF depend, apart from NF-kappaB-directed gene transcription, largely on its ability to activate phospholipase A2(PLA2), yielding the release of arachidonic acid (AA) and its metabolites. AA metabolites, espec...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0404
更新日期:1999-02-01 00:00:00
abstract:AIMS:Osteocalcin, a bone-derived factor, could be a feasible marker for metabolic disorders and adverse cardiovascular outcomes. This study aimed to explore the correlation between serum osteocalcin levels and correct QT interval (QTc) interval prolongation, a risk factor of cardiac morbidity and mortality. METHODS:We...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155261
更新日期:2020-12-01 00:00:00
abstract::We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0450
更新日期:1999-07-01 00:00:00
abstract::Epidemiological studies indicate a genetic contribution to colorectal cancer (CRC), but specific genetic variants remain unknown. Genome-wide association studies have identified rs4444235 at BMP4 as a new colorectal cancer (CRC) and colorectal adenoma (CRA) susceptibility locus in populations of European descent. Afte...
journal_title:Cytokine
pub_type: 杂志文章,meta分析
doi:10.1016/j.cyto.2014.12.021
更新日期:2015-04-01 00:00:00
abstract::Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1999.0512
更新日期:1999-10-01 00:00:00
abstract::Interleukin 6 (IL-6) stimulates fibrinogen (Fg) gene expression both in vivo and in vitro; while interleukin 1 (IL-1) paradoxically stimulates in vivo, yet inhibits in vitro, Fg synthesis. The naturally occurring interleukin 1 receptor antagonist (IL-1ra) and passive immunization with anti-IL-6 antiserum were used to ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90035-4
更新日期:1993-09-01 00:00:00
abstract::We examined seasonal differences in whole blood cytokine production after endotoxin (LPS) stimulation in 17 healthy individuals from an urban area having normal sleep/wakefulness pattern. We used 500 pg/ml of LPS for incubation period of 4 h to stimulate 100 microl of whole blood of the same subjects in June, Septembe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2003.08.005
更新日期:2003-12-21 00:00:00
abstract::TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.1002
更新日期:1995-01-01 00:00:00
abstract:AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2019.02.005
更新日期:2019-05-01 00:00:00
abstract::Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155025
更新日期:2020-05-01 00:00:00
abstract::Interleukin 2 (IL-2)- and IL-4-mediated stimulation of survival and growth, reflected by the induction of bcl2 and c-myc, respectively, depends on the integrity of the membrane-proximal region (S-region) in the IL-2 receptor beta-chain (IL-2R beta) and the haematopoietin homology box1-containing region of the IL-4 rec...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0293
更新日期:1998-05-01 00:00:00
abstract::Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.07.470
更新日期:2008-10-01 00:00:00
abstract::TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines participate including interleukins, IL6 and IL12. Interestingly, TLR2 i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2016.05.007
更新日期:2016-07-01 00:00:00
abstract::C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.011
更新日期:2010-05-01 00:00:00
abstract::Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(91)90018-9
更新日期:1991-05-01 00:00:00
abstract::The burst formation from human and murine burst forming unit-erythroid (BFU-E) requires the presence of erythropoietin (Epo) in semi-solid cultures of bone marrow cells. A number of haematopoietic factors are described that increase the burst number: interleukin 3 (IL-3), stem cell factor (SCF), granulocyte-macrophage...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1998.0335
更新日期:1998-08-01 00:00:00
abstract::Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0706
更新日期:2000-08-01 00:00:00
abstract:AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.05.003
更新日期:2017-05-01 00:00:00
abstract::The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2004.03.013
更新日期:2004-07-07 00:00:00
abstract::Interleukin(IL)-2 and IL-7 are cytokines with important functions related to CD4(+) lymphocyte proliferation, differentiation and survival. Depending on doses, they theoretically activate regulatory (Treg) and/or effector T cells (Teff) and thus may be indicated with different therapeutic objectives. In this study we ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2014.05.021
更新日期:2014-09-01 00:00:00
abstract::We investigated the effects of two low doses of interferon-alpha (IFN-alpha) on nocturnal sleep in 18 healthy men by means of polysomnographic sleep recordings. At 1900h, human recombinant IFN-alpha (1000 or 10000 U/kg body weight) or placebo was administered subcutaneously. Between 2300h and 0700h subjects were allow...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1006/cyto.1999.0587
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Cigarette smoking is a major risk factor for cancer and other diseases. While smoking induces chronic inflammation and aberrant immune responses, the effects of smokeless tobacco products (STPs) on immune responses is less clear. Here we evaluated markers related to immune regulation in smokers (SMK), moist ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155299
更新日期:2021-01-01 00:00:00
abstract::Interleukin-33 (IL-33) is a recently described member of the interleukin-1 (IL-1) family. It is produced by diverse cell types in response to a variety of stresses including hemorrhage and increased mechanical load. Though only relatively recently discovered, IL-33 has been shown to participate in several pathological...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2012.02.008
更新日期:2012-06-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infection and hospitalization in infants. In spite of the enormous clinical burden caused by RSV infections, there remains no efficacious RSV vaccine. CD8 T cells mediate viral clearance as well as provide protection against a secondary ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2018.07.012
更新日期:2020-09-01 00:00:00
abstract::The induction of cytokine expression in monocytes/macrophages by bacterial endotoxin or lipopolysaccharide is a critical, highly regulated host defence response. The augmentation of LPS responses by interferon gamma (IFN-gamma), referred to as priming, is well established. However, the mechanism(s) by which priming oc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0058
更新日期:1995-07-01 00:00:00
abstract::The full-length equine interferon-gamma (eIFN-gamma) cDNA, including the secretion signal peptide coding region, was recloned into baculovirus transfer vector pAcYM1. This vector was co-transfected with Autographa californica nuclear polyhedrosis virus DNA or hybrid nuclear polyhedrosis virus DNA into Spodoptera frugi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2002.1983
更新日期:2002-10-21 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155112
更新日期:2020-07-01 00:00:00
abstract::Type I interferonopathies are characterized by an increase of circulating type I interferon (IFN) concentration. Type I interferonopathies refer to rare Mendelian genetic disorders such as Aicardi-Goutières Syndrome (AGS) as well as more frequent and polygenic auto-immune diseases like systemic lupus erythematosus (SL...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.10.023
更新日期:2019-01-01 00:00:00
abstract::Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0191
更新日期:1997-07-01 00:00:00