当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Potential genetic markers for prediction of treatment response in Egyptian children infected with HCV genotype 4.

Potential genetic markers for prediction of treatment response in Egyptian children infected with HCV genotype 4.

Abstract：

BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association of single nucleotide polymorphisms (SNPs) in interleukins (IL) 10, 28 and 29 genes in predicting the response to therapy in HCV infected children. METHODS:Sixty-six Egyptian children infected with HCV genotype 4, receiving pegylated interferon alpha 2b and ribavirin, were included. Genotyping of six SNPs in interleukin 10, 28B and 29 gene as well as HCV genotype were analyzed by real-time polymerase chain reaction. RESULTS:The CC genotype in IL28B; rs12979860 had 8.547 folds higher chance to develop sustained virological response than CT and TT genotypes (P=0.014). Genotype distribution of rs8099917 in IL28B gene (TG and GG genotypes) was found to be 3.348 more likely not to respond to treatment than the TT genotype (P=0.018). In multivariate analysis, interleukin 28 gene single nucleotide polymorphisms rs 12979860, interleukin 10 single nucleotide polymorphisms -592A > C and basal viral load were independent variables that significantly improved prediction of response to HCV therapy. CONCLUSION:This association can be translated into clinical decision making for HCV treatment.

journal_name

Cytokine

journal_title

Cytokine

authors

Rady NH,Darwish RK,Mogahed EA,Mandour IA,Abo Youssef H,Sharaf SA,El-Karaksy HM

doi

10.1016/j.cyto.2015.04.005

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

349-55

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(15)00156-8

journal_volume

75

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • A state of acquired IL-10 deficiency in 0.4% of Danish blood donors.

    abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.06.009

    authors： de Lemos Rieper C,Galle P,Pedersen BK,Hansen MB

    更新日期：2010-09-01 00:00:00

  • Altered plasma levels of βC and γC chain cytokines and post-treatment modulation in tuberculous lymphadenitis.

    abstract：BACKGROUND:Alterations in β common (βC) and γ common (γC) chain cytokines have been described in pulmonary tuberculosis. However, their role in tuberculous lymphadenitis (TBL) disease has not been assessed. METHODS:Thus, in the present study, we have examined the systemic levels of βC and γC chain cytokines in TBL, la...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155405

    authors： Kathamuthu GR,Moideen K,Sridhar R,Baskaran D,Babu S

    更新日期：2021-02-01 00:00:00

  • A method to induce Interleukin-1 Receptor Antagonist Protein from autologous whole blood.

    abstract：OBJECTIVE:Current orthopedic therapies, aimed solely at symptomatic control, are unable to restore the cytokine imbalance that produces the hallmark clinical profile of osteoarthritis. While a myriad of chemical factors in the cytokine network stimulate local joint inflammation and pain, Interleukin 1 (IL-1) is widely ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2016.03.008

    authors： Barreto A,Braun TR

    更新日期：2016-05-01 00:00:00

  • Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs).

    abstract：:The Toll like receptors (TLRs) and the type I interferons have critical roles to play in innate immunity. In this review we will discuss new developments relating to the important area of TLR/IFN cross regulation. ...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2015.03.001

    authors： Perkins DJ,Vogel SN

    更新日期：2015-08-01 00:00:00

  • Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia.

    abstract：:Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount of information regarding its chemical properties as well as its fundamental role in vascular development. Studies strongly ind...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2014.08.005

    authors： Crafts TD,Jensen AR,Blocher-Smith EC,Markel TA

    更新日期：2015-02-01 00:00:00

  • Function of the human interleukin 4 receptor (IL-4R)-derived acidic motif revealed by cytoplasmic domain chimeras of the IL-4R alpha chain and the IL-2R beta chain.

    abstract：:Interleukin 2 (IL-2)- and IL-4-mediated stimulation of survival and growth, reflected by the induction of bcl2 and c-myc, respectively, depends on the integrity of the membrane-proximal region (S-region) in the IL-2 receptor beta-chain (IL-2R beta) and the haematopoietin homology box1-containing region of the IL-4 rec...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0293

    authors： Deutsch HH,Chung J,Kalthoff FS

    更新日期：1998-05-01 00:00:00

  • Neutrophil-activating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: effect of cyclosporin A.

    abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90500-d

    authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

    更新日期：1991-07-01 00:00:00

  • Regulation of transforming growth factor-beta secretion by human peritoneal mesothelial and ovarian carcinoma cells.

    abstract：:This study was conducted to compare the secretion of TGF-beta isoforms by human ovarian carcinoma (OVCA) cell lines (n=12) and human peritoneal mesothelial cells (HPMC;n=6) and to examine the regulation of their production by inflammatory cytokines. TGF-beta isoforms were furthermore analysed in OVCA-associated asciti...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0632

    authors： Abendstein B,Stadlmann S,Knabbe C,Buck M,Müller-Holzner E,Zeimet AG,Marth C,Obrist P,Krugmann J,Offner FA

    更新日期：2000-07-01 00:00:00

  • Expression of canine interleukin-4 in canine chondrocytes inhibits inflammatory cascade through STAT6.

    abstract：:Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.07.470

    authors： Rachakonda PS,Rai MF,Manning K,Schmidt MF

    更新日期：2008-10-01 00:00:00

  • Enterovirus-induced production of pro-inflammatory and T-helper cytokines by human leukocytes.

    abstract：:Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0786

    authors： Vreugdenhil GR,Wijnands PG,Netea MG,van der Meer JW,Melchers WJ,Galama JM

    更新日期：2000-12-01 00:00:00

  • Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.

    abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155406

    authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

    更新日期：2021-02-01 00:00:00

  • LPS-induced release of IL-1 beta, IL-6, IL-8, TNF-alpha and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein.

    abstract：:We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90080-9

    authors： Eggesbø JB,Hjermann I,Lund PK,Joø GB,Ovstebø R,Kierulf P

    更新日期：1994-09-01 00:00:00

  • Effect of age and hormonal state on cytokine synthesis in the monkey.

    abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0281

    authors： Kaack MB,Harrison RM,Roberts JA

    更新日期：1998-03-01 00:00:00

  • Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

    abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90047-h

    authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

    更新日期：1991-09-01 00:00:00

  • Up-regulation of mitofusin-2 protects CD4+ T cells from HMGB1-mediated immune dysfunction partly through Ca(2+)-NFAT signaling pathway.

    abstract：:High mobility group box 1 protein (HMGB1) was recently discovered to be a critical late-acting cytokine and innate immune-modulating factor in sepsis, but the potential role and mechanism of HMGB1 in adaptive immunity remains elusive. The present study demonstrated that HMGB1 had a dual influence on immune function of...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.03.026

    authors： Zhao GJ,Yao YM,Lu ZQ,Hong GL,Zhu XM,Wu Y,Wang DW,Dong N,Yu Y,Sheng ZY

    更新日期：2012-07-01 00:00:00

  • Association between IL12B polymorphisms and inflammatory bowel disease in Caucasian population: A meta-analysis.

    abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155296

    authors： Wu PB,Wu XM,Qian R,Hong C,Yitian G,Zhang G,Yu YJ

    更新日期：2020-12-01 00:00:00

  • Effect of G(-174)C polymorphism in interleukin-6 gene on cardiovascular disease in type 2 diabetes patients.

    abstract：:Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.12.004

    authors： Buraczynska M,Zukowski P,Drop B,Baranowicz-Gaszczyk I,Ksiazek A

    更新日期：2016-03-01 00:00:00

  • Direct stimulation of cytokines (IL-1 beta, TNF-alpha, IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis.

    abstract：:Rheumatoid arthritis (RA) is an immune disease in which the pathological immune reaction is thought to be initiated by the presentation of an (auto) antigen or superantigen by MHC class II positive cells to CD4 T cells. These successive immunological events can be studied by the cytokines produced at the different sta...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(92)90021-i

    authors： Zangerle PF,De Groote D,Lopez M,Meuleman RJ,Vrindts Y,Fauchet F,Dehart I,Jadoul M,Radoux D,Franchimont P

    更新日期：1992-11-01 00:00:00

  • Plasma level of interferon γ induced protein 10 is a marker of sarcoidosis disease activity.

    abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.07.010

    authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

    更新日期：2013-10-01 00:00:00

  • The TGFβ1 pathway is required for NFκB dependent gene expression in mouse keratinocytes.

    abstract：:The transforming growth factor-beta 1 (TGFβ1) and NFκB pathways are important regulators of epidermal homeostasis, inflammatory responses and carcinogenesis. Previous studies have shown extensive crosstalk between these pathways that is cell type and context dependent, but this has not been well-characterized in epide...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.09.004

    authors： Hogan KA,Ravindran A,Podolsky MA,Glick AB

    更新日期：2013-12-01 00:00:00

  • Expression of interferon-γ, interferon-α and related genes in individuals with Down syndrome and periodontitis.

    abstract：BACKGROUND:Recently, attenuation of anti-inflammatory and increase of pro-inflammatory mediators was demonstrated in individuals with Down syndrome (DS) in comparison with euploid patients during periodontal disease (PD), suggesting a shift to a more aggressive inflammation in DS. AIM:To determine the influence of DS ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.020

    authors： Tanaka MH,Giro EM,Cavalcante LB,Pires JR,Apponi LH,Valentini SR,Spolidório DM,Capela MV,Rossa C Jr,Scarel-Caminaga RM

    更新日期：2012-12-01 00:00:00

  • Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta1 activation and release.

    abstract：BACKGROUND:Although transforming growth factor-beta (TGF-beta), a growth regulator of hepatocytes, induces cell death under pathological conditions, responsiveness of hepatocytes to hypoxic stimulus has not been fully defined. This study aimed at investigating the role of TGF-beta1 in hypoxia-induced hepatotoxicity usi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.03.004

    authors： Kao YH,Jawan B,Goto S,Pan MC,Lin YC,Sun CK,Hsu LW,Tai MH,Cheng YF,Nakano T,Wang CS,Huang CJ,Chen CL

    更新日期：2009-07-01 00:00:00

  • Interferonbeta-induced changes in metallothionein expression and subcellular distribution of zinc in HepG2 cells.

    abstract：:We evaluated the changes of metallothionein induction and cellular zinc distribution in HepG2 cells by interferonbeta treatment. Immunohistochemical staining of metallothionein was observed in the cytoplasm and nuclei of hepatocytes; which was observed predominantly in the cells treated with interferon and zinc compar...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.06.008

    authors： Nagamine T,Kusakabe T,Takada H,Nakazato K,Sakai T,Oikawa M,Satoh T,Arakawa K

    更新日期：2006-06-01 00:00:00

  • RETRACTED: Increases in inflammatory mediators in DRG implicate in the pathogenesis of painful neuropathy in Type 2 diabetes.

    abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.04.009

    authors： Galloway C,Chattopadhyay M

    更新日期：2013-07-01 00:00:00

  • Serum resistin in older patients with hip fracture: Relationship with comorbidity and biochemical determinants of bone metabolism.

    abstract：OBJECTIVES:To determine the relationship of serum resistin concentrations to biochemical determinants of bone metabolism, comorbidity and outcomes in patients with hip fracture (HF). METHODS:In 256 consecutive patients (mean age 81.9±7.8 years; 71.1% women) serum levels of resistin (determined by ELISA), biochemical p...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.06.023

    authors： Fisher A,Southcott E,Li R,Srikusalanukul W,Davis M,Smith P

    更新日期：2011-11-01 00:00:00

  • IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis.

    abstract：:We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.08.007

    authors： Frisullo G,Nociti V,Iorio R,Patanella AK,Marti A,Caggiula M,Mirabella M,Tonali PA,Batocchi AP

    更新日期：2008-10-01 00:00:00

  • Plasma leptin, but not resistin, TNF-α and adiponectin, is associated with echocardiographic parameters of cardiac remodeling in patients with coronary artery disease.

    abstract：:The aim of this research was to assess the relationship between plasma adiponectin, leptin, resistin, tumor necrosis factor alpha (TNF-α) levels and echocardiographic parameters of ventricular remodeling in patients with coronary artery disease, without acute myocardial infarction. The study population consisted of 49...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2018.01.002

    authors： Farcaş AD,Rusu A,Stoia MA,Vida-Simiti LA

    更新日期：2018-03-01 00:00:00

  • Local levels of interleukin-1beta, -4, -6 and tumor necrosis factor alpha in an experimental model of murine osteomyelitis due to staphylococcus aureus.

    abstract：:The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1039

    authors： Yoshii T,Magara S,Miyai D,Nishimura H,Kuroki E,Furudoi S,Komori T,Ohbayashi C

    更新日期：2002-07-21 00:00:00

  • Serum levels of interleukin-2 predict the recurrence of atrial fibrillation after pulmonary vein ablation.

    abstract：AIMS:Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exist...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.026

    authors： Cabrera-Bueno F,Medina-Palomo C,Ruiz-Salas A,Flores A,Rodríguez-Losada N,Barrera A,Jiménez-Navarro M,Alzueta J

    更新日期：2015-05-01 00:00:00

  • Interaction between Snapin and G-CSF receptor.

    abstract：:Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.01.008

    authors： Yuan X,Shan Y,Zhao Z,Chen J,Cong Y

    更新日期：2006-02-21 00:00:00