Abstract:
:Enteroviruses are associated with chronic inflammatory and autoimmune diseases in humans. In these conditions, the cytokine network is supposed to have an important role in inflammation and modulation of the (auto)immune response. In the present study, we demonstrate that coxsackie virus B4 and poliovirus type 1 induce production of pro-inflammatory cytokines IL-1 beta and TNF-alpha in freshly isolated human leucocytes. Furthermore, enteroviruses stimulate the production of cytokines belonging to Th(1)pathways (IFN-gamma, IL-2), and IL-10, which play a role in regulation of the cellular and humoral immune response.
journal_name
Cytokinejournal_title
Cytokineauthors
Vreugdenhil GR,Wijnands PG,Netea MG,van der Meer JW,Melchers WJ,Galama JMdoi
10.1006/cyto.2000.0786keywords:
subject
Has Abstractpub_date
2000-12-01 00:00:00pages
1793-6issue
12eissn
1043-4666issn
1096-0023pii
S1043-4666(00)90786-5journal_volume
12pub_type
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