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Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis.

Abstract：

:Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge Infrastructure (CNKI) and Weipu Database were searched. Data were extracted independently by two authors. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Seventeen potentially eligible articles were identified (4478 cases and 4803 controls). Significant associations between -1082A/G and -592A/C polymorphisms and asthma were observed. However, there was no significant association between -819T/C polymorphism and asthma risk. In addition, there were significant associations of the IL-10 haplotypes with asthma. In summary, this meta-analysis suggested that IL-10 promoter polymorphisms were associated with asthma risk.

journal_name

Cytokine

journal_title

Cytokine

authors

Nie W,Fang Z,Li B,Xiu QY

doi

10.1016/j.cyto.2012.08.023

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

849-55

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(12)00664-3

journal_volume

60

pub_type

杂志文章,meta分析

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