CXC chemokine receptor 4 signaling upon co-activation with stromal cell-derived factor-1α and ubiquitin.

Abstract:

:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-activation of CXCR4 appears to be physiologically relevant. CXCR4 mediated effects of ubiquitin, however, are not well understood and consequences of co-activation of CXCR4 with both ligands are unknown. Utilizing proximity ligation assays and flow cytometry, we detected CXCR4, but not CXCR7, on the cell surface of THP-1 cells, which suggests that confounding effects of CXCR7 are unlikely. Time course and magnitude of reduction of cell surface CXCR4 expression were comparable after stimulation of THP-1 cells with both ligands. SDF-1α was more efficacious than ubiquitin to mobilize Ca(2+). Co-stimulation of THP-1 cells with both ligands resulted in synergistic effects on Ca(2+) fluxes at suboptimal ligand concentrations. Homologous desensitization of Ca(2+) fluxes was detectable with both ligands. SDF-1α pre-stimulation desensitized ubiquitin induced Ca(2+) fluxes, but not vice versa. Effects of SDF-1α and ubiquitin on cAMP levels, Akt and ERK1/2 phosphorylation and chemotactic responses were additive. The chemotactic activities of ubiquitin and SDF-1α were sensitive to AMD3100, pertussis toxin, U73122, LY94002 and U0126. These data suggest that CXCR4 activation with SDF-1α and ubiquitin results in partially synergistic effects on cellular signaling events and in differential effects on receptor desensitization. The ligand ratio that is present in the extracellular environment may contribute to the regulation of CXCR4 mediated functions.

journal_name

Cytokine

journal_title

Cytokine

authors

Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

doi

10.1016/j.cyto.2013.12.008

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

121-5

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(13)00770-9

journal_volume

65

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo.

    abstract::Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and signal transduction. In addition, three homologous genes (T1/ST2, MyD88 and rsc786) have been identified. Expression of the signal...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0359

    authors: Saccani S,Polentarutti N,Penton-Rol G,Sims JE,Mantovani A

    更新日期:1998-10-01 00:00:00

  • Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

    abstract::Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(91)90047-h

    authors: Michiel DF,Garcia GG,Evans GA,Farrar WL

    更新日期:1991-09-01 00:00:00

  • Protective mechanisms of resveratrol derivatives against TNF-α-induced inflammatory responses in rat mesangial cells.

    abstract:INTRODUCTION:Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-pla...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.10.008

    authors: Lee IT,Lin CF,Huang YL,Chong KY,Hsieh MF,Huang TH,Cheng CY

    更新日期:2019-01-01 00:00:00

  • Ingested interferon alpha induces Mx mRNA.

    abstract::We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0450

    authors: Brod SA,Nelson L,Jin R,Wolinsky JS

    更新日期:1999-07-01 00:00:00

  • Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.

    abstract::Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2010.03.014

    authors: Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

    更新日期:2010-07-01 00:00:00

  • The critical role of macrophage migration inhibitory factor in insulin activity.

    abstract::Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2014.05.013

    authors: Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

    更新日期:2014-09-01 00:00:00

  • Elevated urinary sVCAM-1, IL6, sIL6R and TNFR1 concentrations indicate acute kidney transplant rejection in the first 2 weeks after transplantation.

    abstract::We tested the hypothesis that increased urinary cytokine concentrations may indicate an acute kidney transplant rejection. Eight patients with an early rejection in their protocol biopsy about 14days after transplantation (group A), 9 patients with a biopsy proven rejection 2-3months after transplantation (group B) an...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.12.006

    authors: Reinhold SW,Straub RH,Krüger B,Kaess B,Bergler T,Weingart C,Banas MC,Krämer BK,Banas B

    更新日期:2012-03-01 00:00:00

  • Physiological effects of CNTF-induced wasting.

    abstract::The authors have shown previously that in addition to its survival effects on neurons and glia, ciliary neurotrophic factor (CNTF) induced potent cachectic effects and acute phase proteins when present in the peripheral circulation at concentrations of < or = 10 ng/ml. These effects did not depend upon the induction o...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0104

    authors: Henderson JT,Mullen BJ,Roder JC

    更新日期:1996-10-01 00:00:00

  • The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis.

    abstract::The kynurenine pathway (KP) is the major metabolic route of tryptophan (Trp) metabolism. Indoleamine 2,3-dioxygenase (IDO1), the enzyme responsible for the first and rate-limiting step in the pathway, as well as other enzymes in the pathway, have been shown to be highly regulated by cytokines. Hence, the KP has been i...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2017.09.004

    authors: Baumgartner R,Forteza MJ,Ketelhuth DFJ

    更新日期:2019-10-01 00:00:00

  • Interleukin-12 as an adjuvant for induction of protective antibody responses.

    abstract::Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...

    journal_title:Cytokine

    pub_type: 杂志文章,评审

    doi:10.1016/j.cyto.2010.06.011

    authors: Metzger DW

    更新日期:2010-10-01 00:00:00

  • Suppression of dsRNA response genes and innate immunity following Oct4, Stella, and Nanos2 overexpression in mouse embryonic fibroblasts.

    abstract::The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.02.021

    authors: Farshchian M,Matin MM,Armant O,Geerts D,Dastpak M,Nakhaei-Rad S,Tajeran M,Jebelli A,Shahriyari M,Bahrami M,Fallah A,Yaghoobi V,Mirahmadi M,Abbaszadegan MR,Bahrami AR

    更新日期:2018-06-01 00:00:00

  • The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys.

    abstract::A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1998.0384

    authors: Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

    更新日期:1998-12-01 00:00:00

  • Elevated circulating osteoprotegerin and reduced matrix-metalloprotease-9 in post-menopausal women with chronic Hepatitis C virus infection.

    abstract::The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2012.07.006

    authors: Nanda KS,Brady JJ,Murray BF,Sullivan O,Fearon U,McKenna MJ,Hegarty JE,O'Farrelly C,Ryan EJ

    更新日期:2012-11-01 00:00:00

  • The chemokine C10: immunological and functional analysis of the sequence encoded by the novel second exon.

    abstract::The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0060

    authors: Berger MS,Taub DD,Orlofsky A,Kleyman TR,Coupaye-Gerard B,Eisner D,Cohen SA

    更新日期:1996-06-01 00:00:00

  • In vivo effects of cardiotrophin-1.

    abstract::Cardiotrophin-1 (CT-1) is a recently discovered cytokine that was isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. In this study, the effects of chronic administration of CT-1 to mice (0.5 or 2 microg by intraperitoneal injection, twice a day for 14 days) were determined. A dose-dependent ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1996.0123

    authors: Jin H,Yang R,Keller GA,Ryan A,Ko A,Finkle D,Swanson TA,Li W,Pennica D,Wood WI,Paoni NF

    更新日期:1996-12-01 00:00:00

  • Urine epidermal growth factor, monocyte chemoattractant protein-1 or their ratio as predictors of complete remission in primary glomerulonephritis.

    abstract:BACKGROUND:The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF)...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.01.015

    authors: Chanrat E,Worawichawong S,Radinahamed P,Sathirapongsasuti N,Nongnuch A,Assanatham M,Udomsubpayakul U,Kitiyakara C

    更新日期:2018-04-01 00:00:00

  • The circulating levels of TRAIL are extremely low after delivery but rapidly recover in both mothers and newborns.

    abstract::TNF-related apoptosis inducing ligand (TRAIL) plasma levels was measured in plasma samples obtained 1h (time 1) and 2-3 days (time 2) after delivery in a group of healthy women (n=17) who underwent cesarean delivery, and showed a significantly increase from time 1 (39.3 pg/ml median; 41.2 ± 15.9 mean ± SD) to time 2 (...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2013.05.005

    authors: Zauli G,Monasta L,Vecchi Brumatti L,Agnoletto C,Volpi P,Secchiero P

    更新日期:2013-10-01 00:00:00

  • Level of tear cytokines in population-level participants and correlation with clinical features.

    abstract:AIMS:Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a representative adult Chinese population. METHODS:Thirty-nine participan...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2018.05.013

    authors: Tong L,Wong TY,Cheng Y

    更新日期:2018-10-01 00:00:00

  • Granulocyte-macrophage colony stimulating factor induces both HLA-DR expression and cytokine production by human monocytes.

    abstract::The effect of recombinant human granulocyte-macrophage colony stimulating factor (GM-CSF) on the expression of HLA-DR, and the production of the cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) by human peripheral blood monocyte-enriched populations was investigated. GM-CSF was shown to induc...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(90)90044-t

    authors: Chantry D,Turner M,Brennan F,Kingsbury A,Feldmann M

    更新日期:1990-01-01 00:00:00

  • Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit.

    abstract::It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning performance, which was reverted by glatiramer acetate treatment through a mechanism that likely ...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2017.11.010

    authors: Palumbo ML,Di Rosso ME,Simon EH,Gonzalez Murano MR,Genaro AM

    更新日期:2018-07-01 00:00:00

  • PAR-2 activation in intestinal epithelial cells potentiates interleukin-1beta-induced chemokine secretion via MAP kinase signaling pathways.

    abstract::Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2005.06.004

    authors: Fyfe M,Bergström M,Aspengren S,Peterson A

    更新日期:2005-09-07 00:00:00

  • Stimulation of transient receptor potential M3 (TRPM3) channels increases interleukin-8 gene promoter activity involving AP-1 and extracellular signal-regulated protein kinase.

    abstract::Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2017.09.020

    authors: Rubil S,Lesch A,Mukaida N,Thiel G

    更新日期:2018-03-01 00:00:00

  • Nutritional effects on NF-kappaB/IkappaB activity in weight-gaining and -losing rats.

    abstract:BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/s1043-4666(03)00105-4

    authors: Raina N,Jeejeebhoy KN

    更新日期:2003-06-21 00:00:00

  • Circularly permuted interleukin 4 retains proliferative and binding activity.

    abstract::In human interleukin 4(IL-4), the carboxyl and amino termini of the 129 amino acid hormone are close to each other and this region is believed to be important for binding to the IL-4 receptor (IL-4r). We constructed plasmids encoding circularly permuted IL-4 mutants with the peptide Gly-Gly-Asn-Gly-Gly (GGNGG) joining...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1006/cyto.1995.0039

    authors: Kreitman RJ,Puri RK,McPhie P,Pastan I

    更新日期:1995-05-01 00:00:00

  • TGF-beta1 gene polymorphisms influence the course of the disease in non-Hodgkin's lymphoma patients.

    abstract::Non-Hodgkin's lymphomas (NHL) constitute a heterogenous group of mainly B-cell lymphoproliferative diseases with different patterns of clinical behaviour. Biological mechanisms leading to development of NHL are not clearly understood. Transforming growth factor-beta1 (TGF-beta1) influences B cell growth and developmen...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2005.12.010

    authors: Mazur G,Bogunia-Kubik K,Wrobel T,Kuliczkowski K,Lange A

    更新日期:2006-02-07 00:00:00

  • Identification of promising plasma immune biomarkers to differentiate active pulmonary tuberculosis.

    abstract::Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

    journal_title:Cytokine

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.cyto.2016.08.030

    authors: Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

    更新日期:2016-12-01 00:00:00

  • Inhibitory effects of harpagoside on TNF-α-induced pro-inflammatory adipokine expression through PPAR-γ activation in 3T3-L1 adipocytes.

    abstract::Obesity is closely associated with increased production of pro-inflammatory adipokines, including interleukin (IL)-6, plasminogen activator inhibitor (PAI)-1, and adipose-tissue-derived monocyte chemoattractant protein (MCP)-1, which contribute to chronic and low-grade inflammation in adipose tissue. Harpagoside, a ma...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2015.05.015

    authors: Kim TK,Park KS

    更新日期:2015-12-01 00:00:00

  • Tumor necrosis factor α induces a model of preeclampsia in pregnant baboons (Papio hamadryas).

    abstract::Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.06.003

    authors: Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

    更新日期:2011-11-01 00:00:00

  • Presence of interleukin 10 (IL-10) in the ascites of patients with ovarian and other intra-abdominal cancers.

    abstract::Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/1043-4666(92)90082-3

    authors: Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

    更新日期:1992-09-01 00:00:00

  • The G to A polymorphism at -597 of the interleukin-6 gene is extremely rare in southern Han Chinese.

    abstract::Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH pati...

    journal_title:Cytokine

    pub_type: 杂志文章

    doi:10.1016/j.cyto.2011.03.006

    authors: Gao SP,Pan M,Chen C,Ge LJ,Jiang MH,Luan H,Zheng JG,Deng XT,Pan HY,Zhu JH

    更新日期:2011-07-01 00:00:00