Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance.

abstract：:Stimulation of Ca2+ permeable TRPM3 (transient receptor potential melastatin-3) channels with the steroid ligand pregnenolone sulfate activates stimulus-responsive transcription factors, including the transcription factor AP-1 (activator protein-1). As part of a search for AP-1-regulated target genes we analyzed the g...

journal_title：Cytokine

authors： Rubil S,Lesch A,Mukaida N,Thiel G

更新日期：2018-03-01 00:00:00

abstract：:We investigated whether healthy young (age ≤ 40) and elderly (age ≥ 65) people infected with cytomegalovirus (CMV) had similar levels of CD8(+) T cell cytokine production and proliferation in response to an immunodominant CMV pp65 peptide pool given the role of CD8(+) T cells in controlling viral infection and the ass...

journal_title：Cytokine

authors： Shin MS,Lee JS,Lee N,Lee WW,Kim SH,Kang I

更新日期：2013-02-01 00:00:00

abstract：:During T-lymphocyte differentiation in the thymus, the majority of thymocytes die by apoptosis in situ. This process is characterized by internucleosomal DNA fragmentation and is induced by a number of stimuli including glucocorticoids, calcium ionophore, cAMP and 12-o-tetradecanoylphorbol 13-acetate (TPA). In this st...

journal_title：Cytokine

authors： Kizaki H,Nakada S,Ohnishi Y,Azuma Y,Mizuno Y,Tadakuma T

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Immune and inflammatory responses, mediated by cytokines, play important roles in the pathophysiology of asthma. These responses are associated with over expression of T helper (Th)-2 cytokine, particularly interleukin (IL)-4 and IL-5, and decreased expression of Th-1 cytokine, IL-2 and IFN-γ. We...

journal_title：Cytokine

authors： Lama M,Chatterjee M,Nayak CR,Chaudhuri TK

更新日期：2011-09-01 00:00:00

abstract：:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...

journal_title：Cytokine

authors： Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is the key regulator of angiogenesis in the development of various cancers. Previous studies have examined the relationship between VEGF gene promoter polymorphisms such as -2578C/A and -460C/T and bladder cancer risk; however, these results are inconclusive. Therefo...

journal_title：Cytokine

authors： Chen CH,Ho CH,Kuan-Hua Huang S,Shen CH,Wu CC,Wang YH

更新日期：2020-07-01 00:00:00

abstract：:To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistoc...

journal_title：Cytokine

authors： Tournadre A,Porcherot M,Chérin P,Marie I,Hachulla E,Miossec P

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...

journal_title：Cytokine

authors： Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

更新日期：2018-04-01 00:00:00

abstract：:Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. Oral epithelial cells are involved in innate immunity against Candida infections via Toll-like receptors (TLRs) and inflammatory mediators. We investig...

journal_title：Cytokine

authors： Décanis N,Savignac K,Rouabhia M

更新日期：2009-02-01 00:00:00

abstract：:Parasites of the genus Leishmania cause the disease leishmaniasis. As the sandfly vector transfers the promastigotes into the skin of the human host, the infection is either cured or exacerbated. In the process, there emerge several unsolved paradoxes of leishmaniasis. Chronologically, as the infections starts in skin...

journal_title：Cytokine

authors： Saha B,Bhattacharjee S,Sarkar A,Bhor R,Pai K,Bodhale N

更新日期：2020-09-29 00:00:00

abstract：:We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37 degrees C for 1 h suppressed phagocytosis of serum-opson...

journal_title：Cytokine

authors： Roilides E,Katsifa H,Tsaparidou S,Stergiopoulou T,Panteliadis C,Walsh TJ

更新日期：2000-04-01 00:00:00

abstract：:The human interferon alpha-receptor (IFNAR gene product or IFN alpha R protein) was expressed in hamster CHO cells and in mouse A9 cells. The response of the IFN alpha R cDNA transfectants to human IFNs was studied by measuring induction of (2'-5') A synthetase (2'-5' AS). In the murine cells, the IFN alpha R protein ...

journal_title：Cytokine

authors： Abramovich C,Chebath J,Revel M

更新日期：1994-07-01 00:00:00

abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

journal_title：Cytokine

authors： Ghildiyal R,Sen E

更新日期：2017-01-01 00:00:00

abstract：:Stem cell therapy is a promising strategy for recovering of injured cardiac tissue after acute myocardial infarction. The effects promoted by preventive physical training, beneficial for regeneration, are not yet understood on stem cell homing. In the present study, we evaluated the effect of preventive physical train...

journal_title：Cytokine

authors： Schaun MI,Kristochek M,Dias LD,Peres TR,Lehnen AM,Irigoyen MC,Markoski MM

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Tumor necrosis factor (TNFα) is a proinflammatory cytokine and has been a target for intervention in human sepsis. However, inhibition of TNF-α with a high dose of a TNF-receptor fusion protein in patients with septic shock worsened patient survival. This study was designed to investigate whether blocking TNF-α...

journal_title：Cytokine

authors： Tsay TB,Yang MC,Chen PH,Lai KH,Huang HT,Hsu CM,Chen LW

更新日期：2013-07-01 00:00:00

abstract：:MicroRNAs (miRs) were only discovered little more than a decade ago, yet it has become rapidly clear that they are crucial posttranscriptional regulators of gene expression by decreasing the abundance or translational efficiency of mRNAs [Maroney PA, Yu Y, Nilsen TW. MicroRNAs, mRNAs, and translation. Cold Spring Harb...

journal_title：Cytokine

authors： Pedersen I,David M

更新日期：2008-09-01 00:00:00

abstract：:We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to conta...

journal_title：Cytokine

authors： Kumar S,Hanning CR,Brigham-Burke MR,Rieman DJ,Lehr R,Khandekar S,Kirkpatrick RB,Scott GF,Lee JC,Lynch FJ,Gao W,Gambotto A,Lotze MT

更新日期：2002-04-21 00:00:00

abstract：:Rheumatoid arthritis (RA) is a common autoimmune disease that is marked by a systemic inflammatory reaction and joint erosions. Elevated levels of B cell activating factor (BAFF) have been detected in the serum and synovial fluid of RA patients. Moreover, the levels of BAFF increase in cases of autoimmune disease and ...

journal_title：Cytokine

authors： Wei F,Chang Y,Wei W

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

journal_title：Cytokine

authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

更新日期：2011-07-01 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：:The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates a battery of antioxidant, detoxification, and cell stress genes. It is activated by oxidative stress and a number of exogenous compounds, one of which is tert-butylhydroquinone (tBHQ), a widely used food preservative. Nrf2 modulates ...

journal_title：Cytokine

authors： Turley AE,Zagorski JW,Rockwell CE

更新日期：2015-02-01 00:00:00

abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

journal_title：Cytokine

authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

更新日期：1992-11-01 00:00:00

abstract：:The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to...

journal_title：Cytokine

authors： Paul WE

更新日期：2015-09-01 00:00:00

abstract：:The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...

journal_title：Cytokine

authors： Dizdar O,Kalyoncu U,Karadag O,Akdogan A,Kiraz S,Ertenli I,Barista I,Calguneri M

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:Resveratrol has been reported to alleviate inflammatory responses and oxidative stress in mesangial cells and in several types of renal injury in animal models. Previously, the active resveratrol derivatives from the roots of Vitis thunbergii Sieb. & Zucc. (Vitaceae) were shown to have significant anti-pla...

journal_title：Cytokine

authors： Lee IT,Lin CF,Huang YL,Chong KY,Hsieh MF,Huang TH,Cheng CY

更新日期：2019-01-01 00:00:00

abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

journal_title：Cytokine

authors： Gjermandsen IM,Justesen J,Martensen PM

更新日期：2000-03-01 00:00:00

abstract：:The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...

journal_title：Cytokine

authors： Yoza BK,McCall CE

更新日期：2011-02-01 00:00:00

abstract：:Organ failure is associated with increased mortality and morbidity in patients with systemic inflammatory response syndrome. Previously, we showed that a short course of infusion of a hydrogen sulfide (H(2)S) donor reduced metabolism with concurrent reduction of lung injury. Here, we hypothesize that prolonged H(2)S i...

journal_title：Cytokine

authors： Aslami H,Beurskens CJ,de Beer FM,Kuipers MT,Roelofs JJ,Hegeman MA,Van der Sluijs KF,Schultz MJ,Juffermans NP

更新日期：2013-02-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...

journal_title：Cytokine

authors： Takagi H,Furuya N,Kojima N

更新日期：2007-12-01 00:00:00