当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Th1 and Th17 balance in inflammatory myopathies: interaction with dendritic cells and possible link with response to high-dose immunoglobulins.

Th1 and Th17 balance in inflammatory myopathies: interaction with dendritic cells and possible link with response to high-dose immunoglobulins.

Abstract：

:To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistochemistry in muscle biopsies from 13 patients (11 with polymyositis (PM) and 2 dermatomyositis (DM)) obtained before treatment with IVIG. The Th1/Th17 cytokine and the immature/mature DC ratio were studied according to the response to IVIG. Immature DCs were rarely detected compared to mature DCs, observed in all samples except one PM. IFN-gamma-producing cell count was higher than IL-17 count. Neither the expression of IFN-gamma nor IL-17 was correlated with that of DC subsets. Seven of the 13 patients (6 PM and 1 DM) responded to IVIG. T cells and DC subsets were not differentially expressed between responders and non-responders. The frequency of IFN-gamma-producing cells was significantly higher in non-responders with an increased IFN-gamma/IL-17-producing-cell ratio. In conclusion, mature rather than immature DC and IFN-gamma-rather than IL-17-producing cells accumulate in inflamed muscle. Increased IFN-gamma-producing cell count and IFN-gamma/IL-17-ratio were found in IVIG non-responders, suggesting a role for the Th17 mediated pathway in the response to IVIG.

journal_name

Cytokine

journal_title

Cytokine

authors

Tournadre A,Porcherot M,Chérin P,Marie I,Hachulla E,Miossec P

doi

10.1016/j.cyto.2009.02.013

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

297-301

issue

3

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(09)00066-0

journal_volume

46

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Chemokine/cytokine profiling after rituximab: reciprocal expression of BCA-1/CXCL13 and BAFF in childhood OMS.

    abstract：:The aim of the study was to test the hypothesis that B-cell repopulation following rituximab (anti-CD20) therapy is orchestrated by chemokines and non-chemokine cytokines. Twenty-five children with opsoclonus-myoclonus syndrome (OMS) received rituximab with or without conventional agents. A comprehensive panel of 40 c...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.12.004

    authors： Pranzatelli MR,Tate ED,Travelstead AL,Verhulst SJ

    更新日期：2011-03-01 00:00:00

  • Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults.

    abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.03.020

    authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

    更新日期：2011-07-01 00:00:00

  • Association of interleukin-17A polymorphisms with the risk of colorectal cancer: A case-control study.

    abstract：BACKGROUND:Interleukin (IL)-17A is proinflammatory cytokine produced by Th17 cells, which play key, but sometimes inconsistent role in autoimmunity and cancer. Polymorphic variants in IL-17A gene were differentially associated with susceptibility to cancer, including colorectal cancer (CRC). AIM:We investigated the as...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.04.017

    authors： Bedoui SA,Barbirou M,Stayoussef M,Dallel M,Mokrani A,Makni L,Mezlini A,Bouhaouala B,Yacoubi-Loueslati B,Almawi WY

    更新日期：2018-10-01 00:00:00

  • Interferon-γ induces biphasic changes in caldesmon localization as well as adherens junction organization and expression in HUVECs.

    abstract：:Endothelial barrier dysfunction leads to increased endothelial permeability and is an early step in the development of vascular inflammatory diseases such as atherosclerosis. Interferon-γ (IFN-γ), a proinflammatory cytokine, is known to cause increased endothelial permeability. However, the mechanisms by which IFN-γ d...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.06.010

    authors： Ng CT,Fong LY,Yong YK,Hakim MN,Ahmad Z

    更新日期：2018-11-01 00:00:00

  • The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia.

    abstract：:Preeclampsia is a complex disease of pregnancy with both feto-placental and maternal factors contributing to its pathogenesis. Although the cause of this disease is uncertain, imbalance between pro-and anti-inflammatory cytokines has been implicated in the pathogenesis of preeclampsia. Increased levels of the inflamma...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.07.039

    authors： Xiao JP,Yin YX,Gao YF,Lau S,Shen F,Zhao M,Chen Q

    更新日期：2012-12-01 00:00:00

  • Protection against gram-negative bacteremia in neutropenic mice with recombinant granulocyte-macrophage colony-stimulating factor.

    abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates production of neutrophils in bone marrow and may decrease the incidence of infection during neutropenia. We evaluated the protective role of recombinant GM-CSF against Pseudomonas aeruginosa challenge in neutropenic mice. CD-1 mice treated with cyclo...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(90)90030-w

    authors： Bermudez LE,Martinelli JC,Gascon R,Wu M,Young LS

    更新日期：1990-07-01 00:00:00

  • Interleukin-10 controls human peripheral PMN activation triggered by lipopolysaccharide.

    abstract：:Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.03.025

    authors： Martire-Greco D,Rodriguez-Rodrigues N,Landoni VI,Rearte B,Isturiz MA,Fernández GC

    更新日期：2013-06-01 00:00:00

  • Circularly permuted interleukin 4 retains proliferative and binding activity.

    abstract：:In human interleukin 4(IL-4), the carboxyl and amino termini of the 129 amino acid hormone are close to each other and this region is believed to be important for binding to the IL-4 receptor (IL-4r). We constructed plasmids encoding circularly permuted IL-4 mutants with the peptide Gly-Gly-Asn-Gly-Gly (GGNGG) joining...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.0039

    authors： Kreitman RJ,Puri RK,McPhie P,Pastan I

    更新日期：1995-05-01 00:00:00

  • The effect of second-line antirheumatic drugs on interleukin-8 mRNA synthesis and protein secretion in human endothelial cells.

    abstract：:Interactions between interleukin 8 (IL-8) and endothelial cells play an important role in the emigration of mononuclear cells from the blood into areas of inflammation. We examined the ability of specific second-line antirheumatic drugs to regulate (IL-8) gene expression and protein secretion in interleukin 1 (IL-1) s...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(92)90085-6

    authors： Deleuran B,Kristensen M,Paludan K,Zachariae C,Larsen CG,Zachariae E,Thestrup-Pedersen K

    更新日期：1992-09-01 00:00:00

  • Tumor necrosis factor α induces a model of preeclampsia in pregnant baboons (Papio hamadryas).

    abstract：:Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.06.003

    authors： Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

    更新日期：2011-11-01 00:00:00

  • G-CSF-induced evacuation of sinusoidal NK cells and the facilitation of liver regeneration in a partial hepatectomy.

    abstract：:Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.04.001

    authors： Oishi K,Hayamizu K,Aihaiti X,Itamoto T,Arihiro K,Asahara T

    更新日期：2006-04-01 00:00:00

  • Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.

    abstract：:Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liver diseases. TNF has pleiotropic functions, but its role in liver fibrosis has not been clarified. Chronic repeated injection of C...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.11.001

    authors： Sudo K,Yamada Y,Moriwaki H,Saito K,Seishima M

    更新日期：2005-03-07 00:00:00

  • Leishmania major strains isolated from distinct endemic areas show diverse cytokine mRNA expression levels in C57BL/6 mice: Toward selecting an ideal strain for the vaccine studies.

    abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.05.022

    authors： Darabi S,Khaze V,Riazi-Rad F,Darabi H,Bahrami F,Ajdary S,Alimohammadian MH

    更新日期：2015-12-01 00:00:00

  • Impaired production of IL-12 in systemic lupus erythematosus. III: deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression.

    abstract：:Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0512

    authors： Liu TF,Jones BM,Wong RW,Srivastava G

    更新日期：1999-10-01 00:00:00

  • Implication of STAT1 and STAT3 transcription factors in the response to superantigens.

    abstract：:The activation of STAT1 and STAT3 in response to SEB was analyzed in spleen of Balb/c mice. The intraperitoneal injection of the superantigen SEB activated STAT1 and STAT3 in spleen. Activated STAT1 almost completely disappeared in 24 h even though activated STAT3 was present for more than 48 h after SEB injection. Cy...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.09.006

    authors： Plaza R,Vidal S,Rodriguez-Sanchez JL,Juarez C

    更新日期：2004-01-07 00:00:00

  • Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct.

    abstract：:This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.008

    authors： Hokari M,Kuroda S,Chiba Y,Maruichi K,Iwasaki Y

    更新日期：2009-05-01 00:00:00

  • Leukaemia inhibitory factor (LIF) production in pleural effusions: comparison with production of IL-4, IL-8, IL-10 and macrophage-colony stimulating factor (M-CSF).

    abstract：:Leukaemia inhibitory factor (LIF), a pleiotropic cytokine detected in various inflammatory body fluids, plays a poorly defined role in the pathogenesis of human disease. This study was conducted to correlate the LIF concentrations in pleural effusions with the type of pathology and to compare its levels with those of ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0056

    authors： Heymann D,L'Her E,NGuyen JM,Raher S,Canfrère I,Coupey L,Fixe P,Chailleux E,De Groote D,Praloran V,Godard A

    更新日期：1996-05-01 00:00:00

  • Effect of antioxidants on apoptosis and cytokine release in fetal rat Type II pneumocytes exposed to hyperoxia and nitric oxide.

    abstract：:The response of the fetal rat Type II pneumocyte (FTIIP), the stem cell of the alveolar epithelium, to hyperoxia would be helpful to understand the effects of oxygen-induced injury to the developing lung. Our goals were to evaluate the effect of antioxidants (AO) on apoptosis and release of cytokines in freshly isolat...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.06.001

    authors： Johnson-Varghese L,Brodsky N,Bhandari V

    更新日期：2004-10-07 00:00:00

  • Ccl22/MDC, is a prostaglandin dependent pyrogen, acting in the anterior hypothalamus to induce hyperthermia via activation of brown adipose tissue.

    abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.11.017

    authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

    更新日期：2011-03-01 00:00:00

  • Expression and functional analysis of chemokine receptors in human peripheral blood leukocyte populations.

    abstract：:Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0851

    authors： Patel L,Charlton SJ,Chambers JK,Macphee CH

    更新日期：2001-04-07 00:00:00

  • Upregulation of osteopontin expression via the interaction of macrophages and fibroblasts under IL-1b stimulation.

    abstract：BACKGROUND:Fibrosis is attributed to dysregulation of tissue-remodeling. In remodeling areas, fibroblasts and macrophages actively make contact with each other. Osteopontin (OPN) is a pro-fibrotic molecule, whose expression is upregulated by interleukin (IL)-1β via secretion of its downstream cytokines, such as IL-6. H...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.04.025

    authors： Shimodaira T,Matsuda K,Uchibori T,Sugano M,Uehara T,Honda T

    更新日期：2018-10-01 00:00:00

  • Differential regulation of TNF-alpha, IL-6 and IL-10 in UVB-irradiated human keratinocytes via cyclic AMP/protein kinase A pathway.

    abstract：:Pro-inflammatory cytokines are important mediators of cutaneous cellular activities during many skin diseases. In the present study, we investigated the production of tumor necrosis factor-alpha (TNF-alpha), IL-6 and IL-10 by UVB-irradiated human keratinocytes NCTC 2544 cell line in the presence of cAMP-elevating agen...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00224-2

    authors： Grandjean-Laquerriere A,Le Naour R,Gangloff SC,Guenounou M

    更新日期：2003-08-21 00:00:00

  • Low serum interleukin-6 levels as a predictive marker of recurrence in patients with hepatitis B virus related hepatocellular carcinoma who underwent curative treatment.

    abstract：BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.02.027

    authors： Cho HJ,Kim SS,Ahn SJ,Park SY,Park JH,Kim JK,Wang HJ,Cheong JY,Cho SW

    更新日期：2015-06-01 00:00:00

  • IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells.

    abstract：:Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.06.002

    authors： Zhou Y,Toh ML,Zrioual S,Miossec P

    更新日期：2007-06-01 00:00:00

  • The pneumotoxicant paraquat induces IL-8 mRNA in human mononuclear cells and pulmonary epithelial cells.

    abstract：:Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(93)90045-7

    authors： Bianchi M,Fantuzzi G,Bertini R,Perin L,Salmona M,Ghezzi P

    更新日期：1993-09-01 00:00:00

  • The relationship between cotinine concentrations and inflammatory markers among highly secondhand smoke exposed non-smoking adolescents.

    abstract：BACKGROUND:Secondhand smoke (SHS) exposure is a risk factor of respiratory, cardiovascular and inflammatory diseases, however its association with inflammatory markers among highly SHS exposed adolescents has not yet been explored. METHODS:Participants included in this study were a subset of 68 non-smoking adolescents...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.12.007

    authors： Matsunaga Y,Vardavas CI,Plada M,Wärnberg J,Gómez-Martinez S,Tzatzarakis MN,Tsatsakis AM,Díaz EL,Marcos A,Kafatos AG

    更新日期：2014-03-01 00:00:00

  • Macrophage inflammatory protein-1alpha: a link between innate immunity and familial Mediterranean fever?

    abstract：:The aim of this study is to investigate the relationship between chemokines and the inflammation in Familial Mediterranean Fever (FMF). Forty-nine patients with FMF (41 in remission and 8 in acute attack period) and 20 healthy controls were included in the study. Serum levels of macrophage inflammatory protein-1alpha ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.12.005

    authors： Dizdar O,Kalyoncu U,Karadag O,Akdogan A,Kiraz S,Ertenli I,Barista I,Calguneri M

    更新日期：2007-01-01 00:00:00

  • The -251A>T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery.

    abstract：BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.02.007

    authors： Wang Z,Shao J,Zhou Q,Liu J,Zhu Y,Yang J,Wei M

    更新日期：2010-06-01 00:00:00

  • Mitochondrial STAT3: Powering up a potent factor.

    abstract：:The JAK-STAT3 signaling pathway is engaged by many cytokines and growth factor stimuli to control diverse biological processes including proliferation, angiogenesis, survival, immune modulation, and metabolism. For over two decades it has been accepted that STAT3-dependent biology is due to its potency as a transcript...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2016.05.019

    authors： Garama DJ,White CL,Balic JJ,Gough DJ

    更新日期：2016-11-01 00:00:00

  • Glycosaminoglycans alter the conformation of interferon-gamma.

    abstract：:Interferon-gamma (IFN-gamma) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secon...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0592

    authors： Balasubramanian V,Ramanathan M

    更新日期：2000-05-01 00:00:00