The -251A>T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery.

abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

journal_title：Cytokine

authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

更新日期：2002-08-21 00:00:00

abstract：:Interleukin (IL-) 2 and IL-15 share the IL-2 receptor betagamma c subunits (IL-2Rbetagamma c) but have specific, unique alpha receptor subunits. We studied species specificity of human (hu), simian (si), and mouse (mu) IL-15 and found that hu and si IL-15 behaved similarly in all systems investigated. Hu and mu IL-15 ...

journal_title：Cytokine

authors： Eisenman J,Ahdieh M,Beers C,Brasel K,Kennedy MK,Le T,Bonnert TP,Paxton RJ,Park LS

更新日期：2002-11-07 00:00:00

abstract：:The effects of interleukin 1beta administration on the thymus of adult and old rats were studied in order to study the interactions between the nervous and immune systems and to confirm the important role played by catecholaminergic nerve fibres (CNF) in the regulation of thymic functions. Moreover, chemical sympathec...

journal_title：Cytokine

authors： Artico M,Cavallotti C,Cameroni M,Cavallotti D

更新日期：2001-09-07 00:00:00

abstract：:The regulation of local L-tryptophan concentrations by tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO) induced by various stimuli such as interferon-γ (IFN-γ) is one of the key mechanisms in antimicrobial effect. Recently, IDO is also focused on an immunosuppressive mechanism shared by several different...

journal_title：Cytokine

authors： Murakami Y,Hoshi M,Hara A,Takemura M,Arioka Y,Yamamoto Y,Matsunami H,Funato T,Seishima M,Saito K

更新日期：2012-08-01 00:00:00

abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

journal_title：Cytokine

authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

更新日期：2015-02-01 00:00:00

abstract：:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...

journal_title：Cytokine

authors： Ghadge AA,Khaire AA

更新日期：2019-09-01 00:00:00

abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

journal_title：Cytokine

authors： Stumpo R,Kauer M,Martin S,Kolb H

更新日期：2003-10-01 00:00:00

abstract：:Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against var...

journal_title：Cytokine

authors： Metzger DW

更新日期：2010-10-01 00:00:00

abstract：:Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...

journal_title：Cytokine

authors： Maheshwari A,Voitenok NN,Akalovich S,Shaik SS,Randolph DA,Sims B,Patel RP,Killingsworth CR,Fallon MB,Ohls RK

更新日期：2009-04-01 00:00:00

abstract：:Our aim was to explore the putative beneficial effects of low-to-moderate intensity exercise training program in patients with irritable bowel syndrome (IBS). This study evaluated the changes in blood oxidative stress status, inflammatory biomarkers and IBS severity symptoms following 24 weeks of moderate aerobic exer...

journal_title：Cytokine

authors： Hajizadeh Maleki B,Tartibian B,Mooren FC,FitzGerald LZ,Krüger K,Chehrazi M,Malandish A

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Interleukin 17 (IL-17) is induced during the early stages of tuberculosis infection, playing an important role in the defense against mycobacterial infection. To date, only one study performed in Chinese Han population has found an association between IL-17F sequence variants and susceptibility to tuberculos...

journal_title：Cytokine

authors： Ocejo-Vinyals JG,de Mateo EP,Hoz MÁ,Arroyo JL,Agüero R,Ausín F,Fariñas MC

更新日期：2013-10-01 00:00:00

abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

journal_title：Cytokine

authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

更新日期：1991-09-01 00:00:00

abstract：UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...

journal_title：Cytokine

authors： Oppeltz RF,Rani M,Zhang Q,Schwacha MG

更新日期：2011-09-01 00:00:00

abstract：:Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge ...

journal_title：Cytokine

authors： Nie W,Fang Z,Li B,Xiu QY

更新日期：2012-12-01 00:00:00

abstract：:Leukaemia inhibitory factor (LIF), a pleiotropic cytokine detected in various inflammatory body fluids, plays a poorly defined role in the pathogenesis of human disease. This study was conducted to correlate the LIF concentrations in pleural effusions with the type of pathology and to compare its levels with those of ...

journal_title：Cytokine

authors： Heymann D,L'Her E,NGuyen JM,Raher S,Canfrère I,Coupey L,Fixe P,Chailleux E,De Groote D,Praloran V,Godard A

更新日期：1996-05-01 00:00:00

abstract：:In atherosclerotic plaques, macrophages (MAC) and smooth muscle cells (SMC) frequently reside in close proximity and resistin (Rs) and fractalkine (Fk) are present at increased levels, resistin being associated with CD68 macrophages and fractalkine predominantly associated with intimal SMC; however, their role in this...

journal_title：Cytokine

authors： Tucureanu MM,Butoi E,Gan AM,Stan D,Constantinescu CA,Calin M,Simionescu M,Manduteanu I

更新日期：2016-07-01 00:00:00

abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

journal_title：Cytokine

authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

更新日期：1992-11-01 00:00:00

abstract：:Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...

journal_title：Cytokine

authors： Ozgurtas T,Aydin I,Turan O,Koc E,Hirfanoglu IM,Acikel CH,Akyol M,Erbil MK

更新日期：2010-05-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells. Peripheral blood mononuclear cells from healthy subjects were cultured in the presence or absence of different combinations of IL-17s and changes in relative numbers and cell surface ...

journal_title：Cytokine

authors： Al Omar S,Flanagan BF,Almehmadi M,Christmas SE

更新日期：2013-04-01 00:00:00

abstract：INTRODUCTION:Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events. OBJECTIVES:The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year morta...

journal_title：Cytokine

authors： Kamińska J,Stopiński M,Mucha K,Jędrzejczak A,Gołębiowski M,Niewczas MA,Pączek L,Foroncewicz B

更新日期：2019-08-01 00:00:00

abstract：:Bullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the presence of autoantibodies to normal components of the hemidesmosome (BPAg1 and BPAg2). Histology of skin lesions demonstrate a subepidermal vesicle and a predominantly eosinophilic dermal cellular infiltrate. Interleukin 5 (IL-5) pl...

journal_title：Cytokine

authors： Engineer L,Bhol K,Kumari S,Razzaque Ahmed A

更新日期：2001-01-07 00:00:00

abstract：:Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild-type (WT) white adipose tissue (WAT) into ob/ob mice could mimic the effect of recombinant leptin administration in normaliz...

journal_title：Cytokine

authors： Sennello JA,Fayad R,Pini M,Gove ME,Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:To clarify the biological significance of tumour necrosis factor alpha (TNF-alpha) precursor, we analysed its expression at the primed and triggered stages using human monocyte-like cell line THP-1. To prime them, THP-1 cells were treated with either recombinant human interferon gamma (rIFN-gamma) or recombinant human...

journal_title：Cytokine

authors： Tanabe Y,Kitahara-Tanabe N,Mizuno D,Soma GI

更新日期：1994-07-01 00:00:00

abstract：:The immunomodulatory functions of prolactin (PRL) are well recognized. Augmented PRL plasma levels were observed in patients with advanced tuberculosis (TB). Recently, we have reported that LPS and Mycobacterium bovis (M. bovis) induced differential expression of PRL receptor (PRLR) isoforms in THP-1 cells and bovine ...

journal_title：Cytokine

authors： Martínez-Neri PA,López-Rincón G,Mancilla-Jiménez R,del Toro-Arreola S,Muñoz-Valle JF,Fafutis-Morris M,Bueno-Topete MR,Estrada-Chávez C,Pereira-Suárez AL

更新日期：2015-01-01 00:00:00

abstract：:Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...

journal_title：Cytokine

authors： Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

更新日期：2011-12-01 00:00:00

abstract：:Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...

journal_title：Cytokine

authors： Zhou Y,Toh ML,Zrioual S,Miossec P

更新日期：2007-06-01 00:00:00

abstract：:ICAM-1-mediated cell-cell adhesion is essential for different immunologic functions including non-MHC-restricted cytotoxicity. The shedding of a soluble form of ICAM-1 from melanoma impairs immune recognition and leads to tumour escape. Pretreatment of the Foss human melanoma cell line with HILDA/LIF or OSM, two cytok...

journal_title：Cytokine

authors： Heymann D,Godard A,Raher S,Ringeard S,Lassort D,Blanchard F,Harb J

更新日期：1995-02-01 00:00:00

abstract：:Kawasaki disease is a multi-system vasculitis and a primary cause of acquired heart disease among children. Genetic factors may increase susceptibility to Kawasaki disease. TBXA2R is a G-protein-coupled receptor that participates in tissue inflammation and is associated with susceptibility to several diseases, but its...

journal_title：Cytokine

authors： Che D,Pi L,Xu Y,Fu L,Zhou H,Wang Z,Huang P,Zhang L,Gu X

更新日期：2018-11-01 00:00:00

abstract：:ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...

journal_title：Cytokine

authors： Liu B,Jones M,Kong L,Noel T,Jeng EK,Shi S,England CG,Alter S,Miller JS,Cai W,Rhode PR,Wong HC

更新日期：2018-07-01 00:00:00