Abstract：
INTRODUCTION:Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events. OBJECTIVES:The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year mortality in patients with different CKD stages. PATIENTS AND METHODS:Study included 57 CKD patients: 38 in stage 5 (ESRD), 19 in stage 3 and 4 (CKD3-4), and 19 healthy controls. Blood samples were obtained once to measure fetuin A, adiponectin, leptin, tumor necrosis factor (TNF), interleukin-6 (IL-6), metalloproteinase-9 (MMP9), intracellular-1 (ICAM1) and vascular-1 (VCAM1) adhesion molecules (ELISA or Luminex platform). Computed tomography was performed to assess the calcium score (CS). Patients were prospectively followed for 5 years to evaluate their all-cause mortality. RESULTS:Serum VCAM1, TNF and IL-6 were significantly higher in more advanced CKD stages. VCAM1 correlated significantly with ICAM1, TNF and IL-6. TNF and IL-6 were also significantly correlated with each other. No significant changes were detected for other markers. IL-6 correlated significantly with CS, age, renal function and CRP. Elevated CS and IL-6 increased over 3 times the 5-year all-cause and cardiovascular mortality risks in patients with CKD or ESRD at baseline. CONCLUSIONS:IL-6 and CS were significantly associated with 5-year risk of all-cause mortality in CKD patients. Our study suggests an involvement of chronic inflammation linked to coronary artery calcification that is likely to contribute to the cardiovascular mortality in patients with impaired renal function.
journal_name
Cytokinejournal_title
Cytokineauthors
Kamińska J,Stopiński M,Mucha K,Jędrzejczak A,Gołębiowski M,Niewczas MA,Pączek L,Foroncewicz Bdoi
10.1016/j.cyto.2019.04.002subject
Has Abstractpub_date
2019-08-01 00:00:00pages
9-14eissn
1043-4666issn
1096-0023pii
S1043-4666(19)30099-7journal_volume
120pub_type
杂志文章相关文献
CYTOKINE文献大全abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155320
更新日期：2020-10-27 00:00:00
abstract：:Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2012.04.003
更新日期：2012-08-01 00:00:00
abstract：BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/s1043-4666(03)00105-4
更新日期：2003-06-21 00:00:00
abstract：BACKGROUND:Published studies on association between IL12B (G/A) rs10045431, (T/C)rs6887695 polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian population have yielded conflicting results. The aim of this study was to potentially provide more reliable conclusions by conducting a meta-analysis. METHODS:...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155296
更新日期：2020-12-01 00:00:00
abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2003.10.010
更新日期：2004-02-21 00:00:00
abstract：OBJECTIVE:Epicardial adipose tissue (EAT) produces a wide range of adipokines and has recently been linked to the physiopathology of cardiovascular (CV) and metabolic diseases. We aimed to study whether EAT and subcutaneous (SAT) adiponectin and leptin expression levels are associated with CV complications during long-...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.08.012
更新日期：2012-12-01 00:00:00
abstract：:Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1996.0142
更新日期：1997-02-01 00:00:00
abstract：:Leptin, an appetite-regulating hormone/cytokine, circulates both free and bound to soluble leptin receptors (s-leptin R). An electrochemiluminescence (ECL) assay for the quantitative measurement of murine s-leptin R was developed. The absence of s-leptin R immunoreactivity in the serum of db(pas)/db(pas)mice demonstra...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2001.0859
更新日期：2001-04-21 00:00:00
abstract：:Recent studies have implicated leptin as a "stress" hormone and highlighted its association with increases in inflammatory cytokines, C-reactive protein and cortisol. In order to investigate the exact temporal leptin response to stress we undertook a detailed longitudinal study of circulating leptin concentrations dur...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2000.0674
更新日期：2000-07-01 00:00:00
abstract：AIMS:Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a representative adult Chinese population. METHODS:Thirty-nine participan...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2018.05.013
更新日期：2018-10-01 00:00:00
abstract：:The aim of this study was to investigate the clinical relevance of lymphocyte-related serum miRNAs to the pathogenesis of acute graft-versus-host disease (aGVHD) and evaluate the predictive and prognosis value of miRNAs. Consecutive patients who received allogeneic peripheral blood stem cell transplantation (allo-PBSC...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2016.05.021
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Two assays--isolated peripheral blood mononuclear cells (PBMC) and a whole blood assay (WBA)--are commonly used to study TNF-alpha production by an individual in order to distinguish between high and low cytokine producers. We assessed the reliability and reproducibility of these assays. METHODS:The PBMC as...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2004.11.011
更新日期：2005-04-07 00:00:00
abstract：:Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2011.08.030
更新日期：2011-12-01 00:00:00
abstract：:As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1alpha, macrophage colony stimulating factor (M-CSF) and TGFbeta were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and we...
journal_title：Cytokine
pub_type： 临床试验,杂志文章
doi：10.1016/s1043-4666(03)00185-6
更新日期：2003-09-21 00:00:00
abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1999.0562
更新日期：2000-04-01 00:00:00
abstract：:The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2015.01.038
更新日期：2015-09-01 00:00:00
abstract：:Oncostatin M (OSM) and leukaemia inhibitory factor (LIF) exhibit pleiotropic biological activities and share many structural and genetic features. The two cytokines bind with high affinity to the same receptor (LIF/OSM receptor), which consists of the LIF receptor alpha chain (LIFRalpha) and the signal transduction un...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1999.0550
更新日期：2000-02-01 00:00:00
abstract：:Hepatitis C virus (HCV) chronic infection causes severe cellular immune dysfunction. Here, we investigated the production of Th17-associated cytokines by peripheral blood mononuclear cells (PBMCs) of untreated patients with HCV, patients presenting an early virologic response (EVR) after 12weeks of treatment with inte...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2017.09.015
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Interleukin-35 (IL-35) is a recently described heterodimeric cytokine that belongs to the IL-12 family and consists of p35 (IL-12a) and EBI3 (IL-27b) subunits. The expression of IL-35 in humans is inducible in response to inflammatory stimuli. Increased IL-35 levels were documented in several autoimmune infl...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155350
更新日期：2021-01-01 00:00:00
abstract：:Leishmania major, the causative agent of zoonotic cutaneous leishmaniasis shows heterogeneity and diverse clinical manifestations in different areas of infection and experimental models. Such polymorphism may cause difficulties in selection of reliable strains for development of prophylaxes. Hence, the aim of this stu...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2015.05.022
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:The initial study has reported the increased level of oncostatin M (OSM) in gingival crevicular fluid (GCF) of chronic periodontitis patients, and no study has reported its level in gingivitis patients. Therefore, the present study has been carried out to measure the level of OSM in gingival crevicular fluid ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.02.002
更新日期：2010-06-01 00:00:00
abstract：:Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1998.0478
更新日期：1999-09-01 00:00:00
abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1006/cyto.2000.0747
更新日期：2000-10-01 00:00:00
abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2010.06.009
更新日期：2010-09-01 00:00:00
abstract：:Hemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disease characterized by overwhelming inflammation response and multiple organ damage. Most of the clinical and laboratory manifestations of HLH are thought to be related to hypercytokinemia and organ infiltration with lymphocytes and histiocytes. The aim...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2016.05.022
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the signaling mechanisms surrounding changes in tight junction (TJ) and the permeability of human intestinal epithelial cell induced by tumor necrosis factor-alpha (TNF-α). METHODS:To confirm that TNF-α induces epithelial barrier hyperpermeability by disrupting tight ju...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.04.008
更新日期：2012-08-01 00:00:00
abstract：:The failure of the immune response to clear the Hepatitis C virus (HCV) results in chronic inflammation that leads to liver cirrhosis. In general, women have a better prognosis than men and this may be associated with increased levels of anti-inflammatory mediators that are positively regulated by female sex hormones....
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.07.006
更新日期：2012-11-01 00:00:00
abstract：:Cytokine profiles were studied during 19 episodes of chemotherapy-induced neutropenia in 17 patients with haematological malignancies. Circulating concentrations of interleukin 1 alpha (IL-1 alpha), tumour necrosis factor alpha (TNF-alpha) and IL-1 receptor antagonist (IL-1ra) were measured before chemotherapy and the...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1997.0223
更新日期：1997-09-01 00:00:00
abstract：:Previously, two binding sites for interleukin 5 (IL-5) were identified on the IL-5 receptor alpha chain (IL-5Ralpha). They are located within the CD loop of the first fibronectin type III (FnIII)-like domain and the EF loop of the second FnIII-like domain. The first binding site was identified by exploiting the differ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1999.0663
更新日期：2000-07-01 00:00:00
abstract：:Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2004.12.011
更新日期：2005-05-07 00:00:00
