Inter-individual and intra-individual variability in TNF-alpha production by human peripheral blood cells in vitro.

abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

journal_title：Cytokine

authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

更新日期：1991-09-01 00:00:00

abstract：:It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...

journal_title：Cytokine

authors： Rebollo A,Mérida I,Gómez J,Pitton C,Silva A,Martínez C,García A

更新日期：1995-04-01 00:00:00

abstract：:D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...

journal_title：Cytokine

authors： Merk M,Mitchell RA,Endres S,Bucala R

更新日期：2012-07-01 00:00:00

abstract：:Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...

journal_title：Cytokine

authors： Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

更新日期：2013-10-01 00:00:00

abstract：:IL-18 is a pleiotropic and multifunctional cytokine that belongs to the IL-1 family. It is produced as a biologically inactive precursor, which is cleaved into its active mature form mainly by caspase-1. The caspase becomes active from its inactive precursor (procaspase-1) upon assembly of an inflammasome. Because of ...

journal_title：Cytokine

authors： Samarani S,Allam O,Sagala P,Aldabah Z,Jenabian MA,Mehraj V,Tremblay C,Routy JP,Amre D,Ahmad A

更新日期：2016-06-01 00:00:00

abstract：:Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...

journal_title：Cytokine

authors： Maheshwari A,Voitenok NN,Akalovich S,Shaik SS,Randolph DA,Sims B,Patel RP,Killingsworth CR,Fallon MB,Ohls RK

更新日期：2009-04-01 00:00:00

abstract：:Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...

journal_title：Cytokine

authors： McNiff PA,Laliberte RE,Svensson L,Pazoles CJ,Gabel CA

更新日期：1995-02-01 00:00:00

abstract：:Prostaglandins (PGs), the arachidonic acid (AA) metabolites of the cyclooxygenase (COX) pathway, and the cytokine TNFalpha play major roles in inflammation and they are synthesised mainly by macrophages. Their syntheses have been shown to be regulated by several factors, including nitric oxide, a further important mac...

journal_title：Cytokine

authors： Guastadisegni C,Nicolini A,Balduzzi M,Ajmone-Cat MA,Minghetti L

更新日期：2002-08-21 00:00:00

abstract：:These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells. Peripheral blood mononuclear cells from healthy subjects were cultured in the presence or absence of different combinations of IL-17s and changes in relative numbers and cell surface ...

journal_title：Cytokine

authors： Al Omar S,Flanagan BF,Almehmadi M,Christmas SE

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Egypt has a high prevalence of hepatitis C virus (HCV) infection. Limitations of the current HCV treatment in children are low rate of sustained virological response, significant side effects and high expenses, making prediction of treatment response crucial. AIM:This study aimed to investigate association ...

journal_title：Cytokine

authors： Rady NH,Darwish RK,Mogahed EA,Mandour IA,Abo Youssef H,Sharaf SA,El-Karaksy HM

更新日期：2015-10-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

journal_title：Cytokine

authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

更新日期：1996-09-01 00:00:00

abstract：:Cytotoxic action of leukocytes may be involved in the pathogenesis of inflammatory heart muscle disorders. We investigated the expression of rat leukocyte chemotactic cytokines--cytokine induced neutrophil chemoattractant (CINC) and JE--in cultured neonatal rat cardiac myocytes; CINC belongs to the interleukin 8 (IL-8...

journal_title：Cytokine

authors： Seino Y,Ikeda U,Sekiguchi H,Morita M,Konishi K,Kasahara T,Shimada K

更新日期：1995-04-01 00:00:00

abstract：:Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild-type (WT) white adipose tissue (WAT) into ob/ob mice could mimic the effect of recombinant leptin administration in normaliz...

journal_title：Cytokine

authors： Sennello JA,Fayad R,Pini M,Gove ME,Fantuzzi G

更新日期：2006-12-01 00:00:00

abstract：:To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulat...

journal_title：Cytokine

authors： Denizot Y,Karoutsos S,Nathan N

更新日期：2001-03-07 00:00:00

abstract：:LIGHT (lymphotoxin-like inducible protein that competes with glycoprotein D for binding herpesvirus entry mediator on T cells) is a recently identified of the tumor necrosis factor alpha (TNF-alpha) ligand superfamily. We wanted to establish whether the presence of chronic viral hepatitis could be implicated in enhanc...

journal_title：Cytokine

authors： Pawlak K,Mysliwiec M,Pawlak D

更新日期：2007-09-01 00:00:00

abstract：:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in t...

journal_title：Cytokine

authors： Dowrick PG,Prescott AR,Warn RM

更新日期：1991-07-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:It is known that interferon (IFN)-gamma plays a critical role in protection against brucellosis. In this study we have investigated several cytokines and chemokines that are associated with IFN-gamma for potential in vitro correlates of protection. We cultured spleen cells in vitro from mice immunized orally with a li...

journal_title：Cytokine

authors： Paranavitana C,Zelazowska E,Izadjoo M,Hoover D

更新日期：2005-04-21 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

journal_title：Cytokine

authors： Bumiller A,Götz F,Rohde W,Dörner G

更新日期：1999-03-01 00:00:00

abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

journal_title：Cytokine

authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

更新日期：2002-11-24 00:00:00

abstract：:Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were performed for heterozygous, homozyg...

journal_title：Cytokine

authors： Huang M,Chen Q,Xiao J,Zhao X,Liu C

更新日期：2012-04-01 00:00:00

abstract：:Interleukin 15 (IL-15) is a cytokine with many functional characteristics that are similar to IL-2. Most of the functional activities that IL-2 and IL-15 support have been evaluated in short-term assays. It was our intention, then, to determine the long-term effects of IL-15 in comparison to IL-2. These studies were p...

journal_title：Cytokine

authors： Farner NL,Gan J,de Jong JL,Leary TP,Fenske TS,Buckley P,Dunlap S,Sondel PM

更新日期：1997-05-01 00:00:00

abstract：:Effector CD4+ T cells can be classified by the cytokines they secrete, with T helper 1 (Th1) cells generating interferon (IFN)γ and Th17 cells secreting interleukin (IL)-17. Both Th1 and Th17 cells are strongly implicated in the initiation and chronicity of autoimmune diseases such as multiple sclerosis. The endoplasm...

journal_title：Cytokine

authors： Pradeep Yeola A,Akbar I,Baillargeon J,Mercy Ignatius Arokia Doss P,Paavilainen VO,Rangachari M

更新日期：2020-05-01 00:00:00

abstract：:Dysregulation of cytokines synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, and others, but observational studies have led to contradictory results. We investigated potential familial influences on the plasma leve...

journal_title：Cytokine

authors： Pantsulaia I,Trofimov S,Kobyliansky E,Livshits G

更新日期：2002-08-07 00:00:00

abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

journal_title：Cytokine

authors： Reche PA

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...

journal_title：Cytokine

authors： Nowroozalizadeh S,Månsson F,da Silva Z,Repits J,Dabo B,Pereira C,Biague A,Albert J,Nielsen J,Aaby P,Fenyö EM,Norrgren H,Holmgren B,Jansson M

更新日期：2009-06-01 00:00:00

abstract：:Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...

journal_title：Cytokine

authors： Lortat-Jacob H,Garrone P,Banchereau J,Grimaud JA

更新日期：1997-02-01 00:00:00

abstract：:CCR2, and its principle ligand MCP-1/CCL2, have been well documented for their ability to induce monocyte infiltration and promote the pathogenesis of rheumatoid arthritis and atherosclerosis. In order to assess additional roles for CCR2, we inserted allogeneic implants into CCR2-/- and MCP-1-/- mice and characterized...

journal_title：Cytokine

authors： Tylaska LA,Boring L,Weng W,Aiello R,Charo IF,Rollins BJ,Gladue RP

更新日期：2002-05-21 00:00:00

abstract：:Encephalitic listeriosis in sheep is a life-threatening disease. However, little is known about the cytokine response and their predictive value in this disease. The aim of present study was to assess the prognostic significance of Tumor Necrosis Factor-α (TNF-α), Interleukin-12(p40) (IL-12 p40), Interleukin-6 (IL-6),...

journal_title：Cytokine

authors： Abdlla OA,Elboshy ME,Reisha EF,Gadlla HA,El-Khodery SA

更新日期：2015-06-01 00:00:00