Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2.

abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

journal_title：Cytokine

authors： Ghildiyal R,Sen E

更新日期：2017-01-01 00:00:00

abstract：:In this study we assessed the usefulness of serum Transforming Growth Factor-beta1 (TGF-beta1) and soluble Fas (sFas) in distinguishing liver cirrhosis (LC) with and without hepatocellular carcinoma (HCC) as compared with alpha-fetoprotein (AFP). Serum TGF-beta1 and sFas levels were measured by ELISA in 51 LC patients...

journal_title：Cytokine

authors： Sacco R,Leuci D,Tortorella C,Fiore G,Marinosci F,Schiraldi O,Antonaci S

更新日期：2000-06-01 00:00:00

abstract：:Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...

journal_title：Cytokine

authors： Lu Y,Xu Y,Yang D,Kemper T,Roggendorf M,Lu M

更新日期：2008-02-01 00:00:00

abstract：:Vascular smooth muscle cells (VSMC) may be programmed by nutrient deprivation. We found that after 2 and 12 h exposure to 75% reduced amino acids, the release of basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF beta 1) from VSMC was significantly greater than that from cells maintained i...

journal_title：Cytokine

authors： Pancholi S,Earle KA

更新日期：2000-09-01 00:00:00

abstract：:In a previous work we demonstrated that monoclonal antibody (mAb) 8C2 recognized a human granulocyte-colony stimulating factor (hG-CSF) region left unmasked after binding to placenta receptors, whereas mAb 6E3 defined a receptor-buried epitope. Herein we examined the role of these antigenic regions on the proliferativ...

journal_title：Cytokine

authors： Marino VJ,Sterin-Prync AE,Roguin LP

更新日期：2003-04-01 00:00:00

abstract：:Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various ...

journal_title：Cytokine

authors： Barker T,Henriksen VT,Rogers VE,Trawick RH,Momberger NG,Lynn Rasmussen G

更新日期：2021-01-23 00:00:00

abstract：:Metabolic syndrome poses a major threat on human health affecting the quality of life. Adipose tissue is an important organ which plays a crucial role in the pathogenesis of metabolic syndrome. Adipocytokines secreted by the adipose tissue plays a critical role in storage, food intake, energy expenditure, lipid and gl...

journal_title：Cytokine

authors： Ghadge AA,Khaire AA

更新日期：2019-09-01 00:00:00

abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

journal_title：Cytokine

authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

更新日期：1996-09-01 00:00:00

abstract：:Imbalance in the production of cytokines and their inhibitors plays a part in inflammation in chronic destructive diseases. Direct cell-cell contact with stimulated T cells markedly induces the production of pro-inflammatory cytokines and matrix metalloproteinases in monocytes. This study demonstrates that direct cont...

journal_title：Cytokine

authors： Vey E,Dayer JM,Burger D

更新日期：1997-07-01 00:00:00

abstract：:We have demonstrated that ingested murine interferon alpha (IFN-alpha) suppressed clinical relapse in chronic relapsing experimental autoimmune encephalomyelitis (CR-EAE), decreased inflammation and suppressed the adoptive transfer of EAE, and is a biological response modifier in patients with multiple sclerosis. We e...

journal_title：Cytokine

authors： Brod SA,Nelson L,Jin R,Wolinsky JS

更新日期：1999-07-01 00:00:00

abstract：:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...

journal_title：Cytokine

authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Yamamoto-Furusho JK

更新日期：2015-10-01 00:00:00

abstract：:Previous studies have suggested that heterotrimeric G(i) proteins, Src tyrosine kinase and phosphatidylinositol-3 kinase (PI3 Kinase) are involved in signaling events induced by lipopolysaccharide (LPS) leading to pro-inflammatory cytokines gene expression. To investigate the involvement of these mediators in Gram-pos...

journal_title：Cytokine

authors： Fan H,Teti G,Ashton S,Guyton K,Tempel GE,Halushka PV,Cook JA

更新日期：2003-06-07 00:00:00

abstract：:Oncostatin M (OSM) and leukaemia inhibitory factor (LIF) exhibit pleiotropic biological activities and share many structural and genetic features. The two cytokines bind with high affinity to the same receptor (LIF/OSM receptor), which consists of the LIF receptor alpha chain (LIFRalpha) and the signal transduction un...

journal_title：Cytokine

authors： Hui W,Bell M,Carroll G

更新日期：2000-02-01 00:00:00

abstract：:Paraquat (PQ) is a herbicide which is highly pneumotoxic by generating reactive oxygen intermediates (ROI). Pro-inflammatory cytokines, particularly IL-1 and TNF, have been implicated in some ROI-mediated pathologies, including bleomycin toxicity and ischaemia/reperfusion injury. We have studied the effect of PQ on th...

journal_title：Cytokine

authors： Bianchi M,Fantuzzi G,Bertini R,Perin L,Salmona M,Ghezzi P

更新日期：1993-09-01 00:00:00

abstract：:Although much research has been done related to biomarker discovery for tuberculosis infection, a set of biomarkers that can discriminate between active and latent TB diseases remains elusive. In the current study we correlate clinical aspects of TB disease with changes in the immune response as determined by biomarke...

journal_title：Cytokine

authors： Zambuzi FA,Cardoso-Silva PM,Espindola MS,Soares LS,Galvão-Lima LJ,Brauer VS,Gomes MS,Amaral LR,Schaller M,Bollela VR,Frantz FG

更新日期：2016-12-01 00:00:00

abstract：:Expression of GPCR fatty acid sensor/receptor genes in adipocytes is modulated by inflammatory mediators, particularly IL-1β. In this study we examined whether the IL-1 gene superfamily member, IL-33, also regulates expression of the fatty acid receptor genes in adipocytes. Human fat cells, differentiated from preadip...

journal_title：Cytokine

authors： Zaibi MS,Kępczyńska MA,Harikumar P,Alomar SY,Trayhurn P

更新日期：2018-10-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) can induce expression of the protective heat shock proteins (hsps) in cardiac cells. We show here that, unlike the stress induced accumulation of hsps, the effect of CT-1 is not accompanied by increased hsp mRNA levels and is insensitive to the RNA synthesis inhibitor actinomycin D, suggesting t...

journal_title：Cytokine

authors： Railson J,Lawrence K,Stephanou A,Brar B,Pennica D,Latchman D

更新日期：2000-11-01 00:00:00

abstract：:Interleukin-21 (IL-21) is overproduced in human intestines affected by inflammatory bowel disease (IBD) and in the gut of mice with DSS-induced colitis. IL-21-deficient mice are largely protected against DSS-induced colitis, indicating that IL-21 plays a key role in the development of IBD. We previously identified a n...

journal_title：Cytokine

authors： Araki A,Nara H,Rahman M,Onoda T,Li J,Juliana FM,Jin L,Murata K,Takeda Y,Asao H

更新日期：2013-05-01 00:00:00

abstract：:Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Although the pathogenesis of AD is not fully understood, we and others have shown that IL-4 plays a key role. In this study we aimed to identify keratinocyte genes regulated by IL-4 that may play important roles in the pathophysiology of AD. HaCat c...

journal_title：Cytokine

authors： Bao L,Shi VY,Chan LS

更新日期：2013-02-01 00:00:00

abstract：:The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...

journal_title：Cytokine

authors： Takagi H,Furuya N,Kojima N

更新日期：2007-12-01 00:00:00

abstract：:Transforming Growth Factor-beta (TGFbeta) is known to be a negative regulator of G1 cyclin/cdk activity. It is not clear whether TGFbeta has any effect on G2 checkpoint kinases. We have found that TGFbeta downregulated the expression of several G2 checkpoint kinases including cdc2, cyclin B1, and cdc25c without causin...

journal_title：Cytokine

authors： Hu X,Cui D,Moscinski LC,Zhang X,Maccachero V,Zuckerman KS

更新日期：2007-02-01 00:00:00

abstract：:The pathogenesis of septic shock is mainly due to unregulated tumour necrosis factor-alpha (TNF-alpha) production. Procalcitonin (PCT) and calcitonin gene-related peptide (CGRP) are alternative transcription products of the calcitonin gene. Since high PCT levels have been described in human sepsis, and since CGRP inhi...

journal_title：Cytokine

authors： Monneret G,Pachot A,Laroche B,Picollet J,Bienvenu J

更新日期：2000-06-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a multifunctional cytokine having primarily anti-apoptotic and anti-inflammatory effects. Recent reports have documented that IL-6 plays a key role in liver regeneration. Intracellular deficiency of S-adenosylmethionine (SAMe) is a hallmark of toxin-induced liver injury. Although the administra...

journal_title：Cytokine

authors： Song Z,Chen T,Deaciuc IV,Uriarte S,Hill D,Barve S,McClain CJ

更新日期：2004-12-21 00:00:00

abstract：:Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overal...

journal_title：Cytokine

authors： Qiu LX,He J,Wang MY,Zhang RX,Shi TY,Zhu ML,Mao C,Sun S,Lv FF,Zheng CL,Zhu XD

更新日期：2011-12-01 00:00:00

abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...

journal_title：Cytokine

authors： Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

更新日期：2004-02-21 00:00:00

abstract：:We investigated inflammatory cytokine response in chronic depressed patients during abdominal surgery. Twenty-five major depressed patients (Group D) and twenty-five patients (Group C) as the control were studied. Plasma interleukin 6 (IL-6), interleukin 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) concentrat...

journal_title：Cytokine

authors： Kudoh A,Katagai H,Takazawa T

更新日期：2001-01-21 00:00:00

abstract：:The immunomodulatory functions of prolactin (PRL) are well recognized. Augmented PRL plasma levels were observed in patients with advanced tuberculosis (TB). Recently, we have reported that LPS and Mycobacterium bovis (M. bovis) induced differential expression of PRL receptor (PRLR) isoforms in THP-1 cells and bovine ...

journal_title：Cytokine

authors： Martínez-Neri PA,López-Rincón G,Mancilla-Jiménez R,del Toro-Arreola S,Muñoz-Valle JF,Fafutis-Morris M,Bueno-Topete MR,Estrada-Chávez C,Pereira-Suárez AL

更新日期：2015-01-01 00:00:00

abstract：:Epithelial cell apoptosis triggered cooperatively by multiple cytokines contributes to the injury induced by inflammatory responses in the lung and elsewhere. Here we show that interferon-gamma (IFN-gamma) sensitizes A549 cells, human lung epithelial cells, to cytokine-mediated apoptosis by upregulating caspase-8 expr...

journal_title：Cytokine

authors： Kim KB,Choi YH,Kim IK,Chung CW,Kim BJ,Park YM,Jung YK

更新日期：2002-12-21 00:00:00

abstract：:Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...

journal_title：Cytokine

authors： Yentis SM,Gooding RP,Riches PG

更新日期：1994-05-01 00:00:00