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Differential alterations in plasma colony-stimulating factor concentrations after coronary artery bypass graft surgery with extracorporeal circulation.

Abstract：

:To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulation (ECC). Plasma G-CSF and M-CSF concentrations increased after weaning of ECC, reached maximum value at the sixth post-operative hour, and remained elevated at the 24th post-operative hour. In contrast, plasma GM-CSF levels did not change. Plasma M-CSF, G-CSF and GM-CSF values were not different whether patients developed post-operative complications or not. In conclusion, M-CSF and G-CSF are produced after CABG surgery despite the use of high aprotinin doses in hope to abrogate the inflammatory response. G-CSF and M-CSF might play a role in the inflammatory process often observed after CABG surgery.

journal_name

Cytokine

journal_title

Cytokine

authors

Denizot Y,Karoutsos S,Nathan N

doi

10.1006/cyto.2000.0834

keywords:

subject

Has Abstract

pub_date

2001-03-07 00:00:00

pages

314-6

issue

5

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(00)90834-2

journal_volume

13

pub_type

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