Abstract:
:The effects of scatter factor on the cytoskeleton of MDCK and PtK2 cells are described. During the first 6 h after the addition of scatter factor, MDCK cells were found to increase their projected areas twofold, as well as the number and size of their F-actin stress fibers. In contrast PtK2 cells showed no change in their projected areas or in their stress fiber content. However, when both MDCK and PtK2 cells began to separate and scatter after approximately 6 h, the size and number of stress fibers was found to decrease considerably. Unscattered PtK2 cells and cells treated with scatter factor which had yet to scatter showed focal contacts present over the whole ventral surface, as judged by staining for both vinculin and talin. After treated cells separated, both vinculin and talin staining were mainly present in focal contacts on the ventral surfaces of the cell bodies and the distal ends of the processes. However, the cell processes showed few focal contacts along their lengths. The distribution of microtubules and vimentin and keratin intermediate filaments also did not change significantly until scattering had occurred. After cell separation, the processes were always packed with microtubules which were often, but not always, rich in detyrosinated alpha-tubulin and often, but not always, packed with intermediate filaments. All these changes in cytoskeletal organization are consistent with the adoption of a much more motile phenotype. The changes found are compared with those brought about by transformation.
journal_name
Cytokinejournal_title
Cytokineauthors
Dowrick PG,Prescott AR,Warn RMdoi
10.1016/1043-4666(91)90498-3subject
Has Abstractpub_date
1991-07-01 00:00:00pages
299-310issue
4eissn
1043-4666issn
1096-0023pii
1043-4666(91)90498-3journal_volume
3pub_type
杂志文章相关文献
CYTOKINE文献大全abstract::Granulocyte colony-stimulating factor (G-CSF) is the major cytokine involved in the control of neutrophil development. G-CSF activates the special receptor, the G-CSF receptor (GCSF-R), which subsequently triggers multiple signaling events. To obtain more interactive molecules with GCSF-R and to further understand the...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.01.008
更新日期:2006-02-21 00:00:00
abstract::CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Leptin-deficient ob/ob mice exhibit several metabolic and immune abnormalities, including thymus atrophy and markedly reduced inflammatory responses. We evaluated whether transplantation of wild-type (WT) white adipose tissue (WAT) into ob/ob mice could mimic the effect of recombinant leptin administration in normaliz...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.02.001
更新日期:2006-12-01 00:00:00
abstract:PURPOSE:Three tear supplements were compared for their effects on the signs, symptoms and inflammatory status of subjects with dry eye disease. Assessments were made before and after both 2 and 4 weeks of treatment. METHODS:In this masked, randomized, 3-way crossover trial, eighteen dry eye subjects were recruited. At...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2018.02.009
更新日期:2018-05-01 00:00:00
abstract:AIMS:At present, there are few studies on the relationship between circulating irisin levels and gestational diabetes mellitus (GDM), and the results are inconsistent. Therefore, this study conducts a systematic review and meta-analysis to comprehensively discuss the role of irisin in the occurrence and development of ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2019.154924
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder which presents with abdominal pain and alterations of the bowel habits. The pathophysiology of IBS is not well-recognized. Low grade inflammation has been suggested as one of the underlying mechanisms of IBS. Variations in the ci...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2017.08.017
更新日期:2017-11-01 00:00:00
abstract::Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.008
更新日期:2010-05-01 00:00:00
abstract::Systemic sclerosis (SSc) has the highest fatality rate among connective tissue diseases and is characterized by vascular damage, inflammation and fibrosis. Currently, no therapy has proven effective in modifying the course of SSc, a reflection of its complex pathogenesis. T cell-derived cytokines have been implicated ...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2011.08.030
更新日期:2011-12-01 00:00:00
abstract:UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.05.004
更新日期:2011-09-01 00:00:00
abstract::L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2000.0712
更新日期:2000-09-01 00:00:00
abstract::The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1996.0112
更新日期:1996-11-01 00:00:00
abstract::We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(94)90080-9
更新日期:1994-09-01 00:00:00
abstract::Cancer metastasis to the lymph nodes is indicative of a poor prognosis. An endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) biopsy is increasingly being used to sample paratracheal lymph nodes for simultaneous cancer diagnosis and staging. In this prospective, single-center study, we collected dedicat...
journal_title:Cytokine
pub_type: 临床试验,杂志文章
doi:10.1016/j.cyto.2016.08.011
更新日期:2017-01-01 00:00:00
abstract:AIMS:There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients. MATERIALS/METHODS:PubMed and Embase datab...
journal_title:Cytokine
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.cyto.2019.02.005
更新日期:2019-05-01 00:00:00
abstract::The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.11.013
更新日期:2012-02-01 00:00:00
abstract::Leprosy is an infectious disease caused by M. leprae. We analyzed 48 cytokine polymorphisms in 13 (pro as well as anti-inflammatory) cytokine genes using PCR-SSP assay in 102 leprosy patients and 120 healthy controls with intent to find out a link between cytokine polymorphisms and disease susceptibility. TNF-α (-308)...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2015.01.014
更新日期:2015-05-01 00:00:00
abstract::IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2017.07.005
更新日期:2017-11-01 00:00:00
abstract::Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.2001.0995
更新日期:2002-02-07 00:00:00
abstract::The protective effect of interleukin 1 alpha (IL-1 alpha) in mice with acetaminophen (AAP)-induced hepatitis was investigated. IL-1 alpha had a significant protective effect if given 2 or more hours (up to 24 hours) before AAP; it significantly reduced mortality of mice and decreased serum transaminase level. The maxi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/1043-4666(93)90004-o
更新日期:1993-05-01 00:00:00
abstract:AIMS:Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a representative adult Chinese population. METHODS:Thirty-nine participan...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2018.05.013
更新日期:2018-10-01 00:00:00
abstract::The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2009.10.002
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2020.155238
更新日期:2020-12-01 00:00:00
abstract::It has been reported that rapamycin (rap), cyclosporin A (CsA) and FK506 have immunosuppressive effect during the activation process of murine T cells. These drugs were investigated for their suppressive effect on a murine T cell line expressing intermediate (TS1 beta) or high (TS1 alpha beta) affinity IL-2R. Rap and ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1995.0033
更新日期:1995-04-01 00:00:00
abstract::Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.12.022
更新日期:2009-04-01 00:00:00
abstract::Transforming growth factor-beta1 (TGFbeta1) induces plasminogen activator inhibitor-1 (PAI-1) as a major target protein. PAI-1 is associated with fibrosis, thrombosis, and metabolic disorders. TGFbeta1 induces PAI-1 via phosphorylation and nuclear translocation of Smads. Oltipraz inhibits TGFbeta1 expression and also ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2006.10.001
更新日期:2006-09-01 00:00:00
abstract::Gangliosides have been extensively described to be involved in the proliferation and differentiation of various cell types, such including hematopoietic cells. Our previous studies on murine models of stroma-mediated myelopoiesis have shown that gangliosides are required for optimal capacity of stromal cells to suppor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2011.08.032
更新日期:2011-12-01 00:00:00
abstract::The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1006/cyto.1997.0322
更新日期:1998-07-01 00:00:00
abstract::We present evidence that cervical cancer cells express a functional IL-2 receptor (IL-2R). In fact, by RT-PCR we obtained that the IL-2R is present in CALO, and INBL cells, and that it consisted of the alphaIL-2R, betaIL-2R, and gammaIL-2R chains. We also found that IL-2 is a growth factor for these cell lines, and un...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.013
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Cutaneous melanoma displays high morbidity and mortality rates. Isolated limb perfusion with melphalan (Mel) is used for the treatment of non-resectable, locally advanced extremity melanomas. When combined with tumor necrosis factor alpha (TNF-alpha) treatment, the complete response varies between 70% and 90...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2013.02.022
更新日期:2013-05-01 00:00:00
abstract::Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2012.04.003
更新日期:2012-08-01 00:00:00