Abstract:
:The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared with the untreated supernatants. IL-10 production and expression of mRNA for IL-10 in Clone 1469 cells was detected by using enzyme-linked immunosorbent assay, ELISPOT assay and PCR amplification. TGF-beta led to augmentation of IL-10 secretion from Clone 1469 cells.
journal_name
Cytokinejournal_title
Cytokineauthors
Ishizaka S,Saito S,Yoshikawa M,Kimoto M,Nishiyama Tdoi
10.1006/cyto.1996.0112subject
Has Abstractpub_date
1996-11-01 00:00:00pages
837-43issue
11eissn
1043-4666issn
1096-0023pii
S1043-4666(96)90112-Xjournal_volume
8pub_type
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