Physiological effects of CNTF-induced wasting.

abstract：:Since liver regeneration after partial hepatectomy (PHx) is known to improve by pretreatment with recombinant human G-CSF (rhG-CSF), we investigated the mechanism by evaluating the distribution and activity of sinusoidal NK cells. F344 rats were treated with rhG-CSF (250 microg/kg/day) for 5 days before PHx. Pretreatm...

journal_title：Cytokine

authors： Oishi K,Hayamizu K,Aihaiti X,Itamoto T,Arihiro K,Asahara T

更新日期：2006-04-01 00:00:00

abstract：:Allogeneic bone marrow transplantation was performed in a 24-year-old woman with acute myelogenous leukemia in the first remission (FAB classification: M4). Graft-versus-host disease occurred from around day 150 after bone marrow transplantation. The levels of tumour necrosis factor-alpha, interleukin 12, and intercel...

journal_title：Cytokine

authors： Takatsuka H,Takemoto Y,Okada M,Sawada A,Katsuno T,Wada H,Kakishita E

更新日期：2000-08-01 00:00:00

abstract：:These experiments were designed to investigate the effects of IL-17 upon the phenotype and function of human Natural Killer (NK) cells. Peripheral blood mononuclear cells from healthy subjects were cultured in the presence or absence of different combinations of IL-17s and changes in relative numbers and cell surface ...

journal_title：Cytokine

authors： Al Omar S,Flanagan BF,Almehmadi M,Christmas SE

更新日期：2013-04-01 00:00:00

abstract：:CC Chemokine ligand 22 (Ccl22) is a selective, high affinity ligand at the CC chemokine receptor 4 (Ccr4). We have identified cDNAs encoding both ligand and receptor of the Ccl22-Ccr4 pair in cDNA libraries of the anterior hypothalamus/pre-optic area (AH/POA) by PCR. The AH/POA is the key brain region where endogenous...

journal_title：Cytokine

authors： Osborn O,Sanchez-Alavez M,Dubins JS,Gonzalez AS,Morrison B,Hadcock JR,Bartfai T

更新日期：2011-03-01 00:00:00

abstract：:The authors describe the design and validation of a competitive RT-PCR method for the efficient and reproducible quantitation of mRNA molecules of IFN-gamma, TNF-alpha, IL-4 and IL-10 in mouse spleen RNA extracts. Before being subjected to RT-PCR, the RNA extracts were supplemented with internal control RNAs (IC-RNAs)...

journal_title：Cytokine

authors： Zhou NM,Matthys P,Polacek C,Fiten P,Sato A,Billiau A,Froyen G

更新日期：1997-03-01 00:00:00

abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

journal_title：Cytokine

authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

更新日期：2019-07-01 00:00:00

abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...

journal_title：Cytokine

authors： Ogawa H,Nishihira J,Sato Y,Kondo M,Takahashi N,Oshima T,Todo S

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:Erythropoietin (EPO) and Stem Cell Factor (SCF) have partially distinct functions in erythroid cell development. The primary functions of EPO are to prevent apoptosis and promote differentiation, with a minor role as a mitogen. On the other hand SCF acts primarily as a mitogenic factor promoting erythroid cell prolife...

journal_title：Cytokine

authors： Geslain R,Uddin S,Liu H,Jiang H,van Besien K,Pan T,Wickrema A

更新日期：2013-01-01 00:00:00

abstract：:Dermal wounding is accompanied by inflammation and the resulting proinflammatory cytokines, including interleukin (IL)-6, are thought to play an important role in the repair process. IL-6 is produced by normal human keratinocytes to various dermatological diseases and we have recently shown it is also required for nor...

journal_title：Cytokine

authors： Sugawara T,Gallucci RM,Simeonova PP,Luster MI

更新日期：2001-09-21 00:00:00

abstract：BACKGROUND:We aimed to investigate the use of novel serum biomarkers for predicting the recurrence and survival of patients with hepatitis B virus (HBV)-related early hepatocellular carcinoma (HCC) after hepatic resection or radiofrequency ablation (RFA). METHODS:One hundred and five patients with HBV-related HCC, who...

journal_title：Cytokine

authors： Cho HJ,Kim SS,Ahn SJ,Park SY,Park JH,Kim JK,Wang HJ,Cheong JY,Cho SW

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Hypertension is one of the most prominent risk factors for coronary artery disease (CAD). Treatment of hypertension is therefore important for reducing cardiovascular events and the progression of atherosclerosis. Several treatment strategies are common in clinical practice for example the use of ACE-blocker...

journal_title：Cytokine

authors： Klinghammer L,Urschel K,Cicha I,Lewczuk P,Raaz-Schrauder D,Achenbach S,Garlichs CD

更新日期：2013-05-01 00:00:00

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1 homologue 1-4 (IL-1H1-4). These proteins exhibit significant sequence homology to other members of the IL-1 family. Of these homologues, only IL-1H4 (renamed IL-1F7b) was predicted to conta...

journal_title：Cytokine

authors： Kumar S,Hanning CR,Brigham-Burke MR,Rieman DJ,Lehr R,Khandekar S,Kirkpatrick RB,Scott GF,Lee JC,Lynch FJ,Gao W,Gambotto A,Lotze MT

更新日期：2002-04-21 00:00:00

abstract：:Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

journal_title：Cytokine

authors： Liu TF,Jones BM,Wong RW,Srivastava G

更新日期：1999-10-01 00:00:00

abstract：:Natural terrestrial ionizing radiations emerge from uranium deposits and can impact human tissues by affecting DNA bases which constitute genes. Human interferon alpha-2b (hIFNα-2b) gene synthesizes a protein which exhibits anticancerous, immunomodulatory, anti-proliferative and antiviral properties. This research aim...

journal_title：Cytokine

authors： Shahid S,Mahmood N,Chaudhry MN,Ahmad N

更新日期：2015-12-01 00:00:00

abstract：:Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates production of neutrophils in bone marrow and may decrease the incidence of infection during neutropenia. We evaluated the protective role of recombinant GM-CSF against Pseudomonas aeruginosa challenge in neutropenic mice. CD-1 mice treated with cyclo...

journal_title：Cytokine

authors： Bermudez LE,Martinelli JC,Gascon R,Wu M,Young LS

更新日期：1990-07-01 00:00:00

abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

journal_title：Cytokine

authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

更新日期：2015-02-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF) is expressed on the cell surface as a transmembrane form (tmTNF), that can be released as a soluble form (solTNF) via proteolytic cleavage. These two types of TNF exert their biological functions by binding to one of two TNF receptors, TNFR1 or TNFR2. However, the biological function ...

journal_title：Cytokine

authors： Shibata H,Abe Y,Yoshioka Y,Nomura T,Sato M,Kayamuro H,Kawara T,Arita S,Furuya T,Nagano K,Yoshikawa T,Kamada H,Tsunoda S,Tsutsumi Y

更新日期：2010-04-01 00:00:00

abstract：:The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...

journal_title：Cytokine

authors： Ishizaka S,Saito S,Yoshikawa M,Kimoto M,Nishiyama T

更新日期：1996-11-01 00:00:00

abstract：:IL-1 strikingly enhances antigen-driven responses of CD4 and CD8 T cells. It is substantially more effective than LPS and when added to a priming regime of antigen plus LPS, it strikingly enhances cell expansion. The effect is mediated by direct action on CD4 and CD8 T cells; the response occurs when OT-I or OT-II cel...

journal_title：Cytokine

authors： Ben-Sasson SZ,Caucheteux S,Crank M,Hu-Li J,Paul WE

更新日期：2011-10-01 00:00:00

abstract：:Cytokines are key mediators of immune responses to autoantigens, tumor antigens and foreign antigens including pathogens and transplant antigens. The cytokines are produced by a variety of immune and non-immune cells and are dynamically regulated. Remarkably, during toxic and septic shock syndromes, anaphylactic shock...

journal_title：Cytokine

authors： Saha B,Silvestre R

更新日期：2020-10-27 00:00:00

abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...

journal_title：Cytokine

authors： Kaack MB,Harrison RM,Roberts JA

更新日期：1998-03-01 00:00:00

abstract：:Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals wer...

journal_title：Cytokine

authors： Teng D,Ding L,Cai B,Luo Q,Wang H

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND AIM:Interleukin-22 (IL-22), plays a vital role in the mucosal repair of inflammatory bowel disease (IBD). Serum levels of IL-22 and IL-22 binding protein (IL-22BP), a soluble inhibitory IL-22 receptor, were measured in patients with IBD to investigate the profile of IL-22 in the systemic circulation. ME...

journal_title：Cytokine

authors： Sakemi R,Mitsuyama K,Morita M,Yoshioka S,Kuwaki K,Tokuyasu H,Fukunaga S,Mori A,Araki T,Yoshimura T,Yamasaki H,Tsuruta K,Morita T,Yamasaki S,Mizoguchi A,Sou S,Torimura T

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Familial Mediterranean fever (FMF) is an autoinflammatory disease caused by mutations in the MEFV gene. Mutations in exon 10 are associated with typical FMF phenotypes, and patients with exon 10 mutations have higher serum levels of interleukin (IL)-18 both during attacks and afebrile phases, compared to tho...

journal_title：Cytokine

authors： Wada T,Toma T,Miyazawa H,Koizumi E,Shirahashi T,Matsuda Y,Yachie A

更新日期：2018-04-01 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：:Leptin, an appetite-regulating hormone/cytokine, circulates both free and bound to soluble leptin receptors (s-leptin R). An electrochemiluminescence (ECL) assay for the quantitative measurement of murine s-leptin R was developed. The absence of s-leptin R immunoreactivity in the serum of db(pas)/db(pas)mice demonstra...

journal_title：Cytokine

authors： Voegeling S,Fantuzzi G

更新日期：2001-04-21 00:00:00

abstract：:Cytokine mRNA expression was analyzed by reverse transcriptase (RT)/PCR in extensively purified normal peripheral CD4+CD45R T cell subsets. Both CD45RA+ and CD45 RO+ populations produced mRNAs for interleukin (IL)-2, IL-2 receptor (alpha chain), IL-6 receptor and tumour necrosis factor (TNF)-beta within 3-4 h of activ...

journal_title：Cytokine

authors： Beckman I,Shepherd K,Dimopoulos K,Ahern M,Firgaira F,Bradley J

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Granulocyte colony-stimulating factor (G-CSF) is the standard-of-care therapy for chemotherapy-associated neutropenia in patients with malignancies. Recent case reports have implied that G-CSF treatment may be associated with the development of aortitis, but the precise nature of the relationship is unclear....

journal_title：Cytokine

authors： Oshima Y,Takahashi S,Tani K,Tojo A

更新日期：2019-07-01 00:00:00