Altered serum profile of the interleukin-22 system in inflammatory bowel disease.

abstract：:Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...

journal_title：Cytokine

authors： Ozgurtas T,Aydin I,Turan O,Koc E,Hirfanoglu IM,Acikel CH,Akyol M,Erbil MK

更新日期：2010-05-01 00:00:00

abstract：:The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on bind...

journal_title：Cytokine

authors： Reche PA

更新日期：2019-04-01 00:00:00

abstract：:The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30× (10-30) biotherapy - BioLi30×. We performed controlled experiments using 8-to-12-week-old mice, infected with 5×107L. infantum proma...

journal_title：Cytokine

authors： Cajueiro APB,Goma EP,Dos Santos HAM,Almeida Rodrigues I,Toma HK,Araújo SM,Bonamin LV,Gomes NBN,Castelo-Branco MTL,de Souza Dias EP,Dos Santos Pyrrho A,Holandino C

更新日期：2017-07-01 00:00:00

abstract：:Cytokine balance alterations are responsible for some of the systemic and hepatic manifestations of alcoholism. The present study was aimed to evaluate the influence of both acute alcohol abstinence (in alcoholics) and acute alcohol intake (in healthy subjects) on serum IL-6, IL-8, IL-10, and IL-12 levels. Serum cytok...

journal_title：Cytokine

authors： González-Quintela A,Dominguez-Santalla MJ,Pérez LF,Vidal C,Lojo S,Barrio E

更新日期：2000-09-01 00:00:00

abstract：:The monocytic cell line U937 is a frequently used model in studies on the cytotoxic effect of tumour necrosis factor (TNF). Two sublines of this cell line, termed U937(G) and U937(M), revealing different patterns of response to this cytokine, have been identified. The U937(G) cells, similarly to the cells obtained fro...

journal_title：Cytokine

authors： Kaszubowska L,Engelmann H,Gotartowska M,Iliszko M,Bigda J

更新日期：2001-03-21 00:00:00

abstract：BACKGROUND:The balance of several cytokines likely influences the resolution of glomerulonephritis. Monocyte chemoattractant protein-1(MCP-1) is a chemokine that promotes renal inflammation whereas epidermal growth factor (EGF) stimulates protective responses. Previously, high urine MCP-1(MCP-1) and low urine EGF (EGF)...

journal_title：Cytokine

authors： Chanrat E,Worawichawong S,Radinahamed P,Sathirapongsasuti N,Nongnuch A,Assanatham M,Udomsubpayakul U,Kitiyakara C

更新日期：2018-04-01 00:00:00

abstract：:Periodontitis is the most prevalent infectious disease caused by periodontopathic bacteria and is also a chronic inflammatory disease. Gingival crevicular fluid (GCF) is an inflammatory exudate that seeps into the gingival crevices or periodontal pockets around teeth with inflamed gingiva, and contains various materia...

journal_title：Cytokine

authors： Yoshimoto T,Fujita T,Kajiya M,Matsuda S,Ouhara K,Shiba H,Kurihara H

更新日期：2015-09-01 00:00:00

abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...

journal_title：Cytokine

authors： Ghildiyal R,Sen E

更新日期：2017-01-01 00:00:00

abstract：:Tumour necrosis factor alpha(TNF-alpha) is one of the most important pro-inflammatory cytokines, which plays an important role in host defense and acute inflammation related to tissue injury. The major source of TNF-alpha has been shown to be immune cells such as macrophages and neutrophils. In the present study, we d...

journal_title：Cytokine

authors： McRitchie DI,Isowa N,Edelson JD,Xavier AM,Cai L,Man HY,Wang YT,Keshavjee SH,Slutsky AS,Liu M

更新日期：2000-06-01 00:00:00

abstract：:The expression of oncostatin M and leukemia inhibitory factor (LIF), JAK-STAT activators and members of the interleukin-6 family of cytokines, were examined in a series of primary ovarian carcinomas using immunohistochemistry. The malignant epithelial cells of all 29 ovarian carcinomas examined expressed oncostatin M;...

journal_title：Cytokine

authors： Savarese TM,Campbell CL,McQuain C,Mitchell K,Guardiani R,Quesenberry PJ,Nelson BE

更新日期：2002-03-21 00:00:00

abstract：:In the present study, we investigated the effect of CdCl2 on the inflammatory cytokines in human intestinal Caco-2 cells. The secretion of IL-8 from Caco-2 cells was significantly increased in a dose- and time-dependent manner, whereas the secretion of such other inflammatory cytokines as TNF-alpha and IFN-gamma was n...

journal_title：Cytokine

authors： Hyun JS,Satsu H,Shimizu M

更新日期：2007-01-01 00:00:00

abstract：:Recently, we reported that extracellular ubiquitin functions as another agonist of CXC chemokine receptor (CXCR)4. Whereas the cognate CXCR4 ligand, stromal cell-derived factor (SDF)-1α, is also a CXCR7 agonist, ubiquitin does not bind to CXCR7. Because both ligands are present in the extracellular environment, co-act...

journal_title：Cytokine

authors： Tripathi A,Davis JD,Staren DM,Volkman BF,Majetschak M

更新日期：2014-02-01 00:00:00

abstract：:The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...

journal_title：Cytokine

authors： Parody TR,Stone MJ

更新日期：2004-07-07 00:00:00

abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

journal_title：Cytokine

authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

更新日期：1992-11-01 00:00:00

abstract：:Most studies have shown that interleukin-1 (IL-1) acts as a helper or co-stimulator in T-lymphocyte activation and proliferation by mitogens or antigens. We describe here a stable subclone (D10S) of the murine D10.G4.1 helper T-cell which proliferates to subfemtomolar (attomolar) concentrations of IL-1 beta or alpha i...

journal_title：Cytokine

authors： Orencole SF,Dinarello CA

更新日期：1989-11-01 00:00:00

abstract：:Neutrophil-activating peptide 1/interleukin 8 (NAP-1/IL-8) is a recently described cytokine with potent chemotactic activity for human neutrophil granulocytes (PMN) and T cells. In psoriasis, a chronic hyperproliferative and inflammatory skin disorder, PMN and T cells are found as prominent cells in the inflammatory i...

journal_title：Cytokine

authors： Mrowietz U,Sticherling M,Mielke V,Schröder JM,Christophers E

更新日期：1991-07-01 00:00:00

abstract：:The clinical phenotype in sepsis that is observed as LPS tolerance is determined by silencing of pro-inflammatory genes like IL-1 beta (IL-1β). This study shows that facultative heterochromatin (fHC) silences IL-1β expression during sepsis, where we find dephosphorylated histone H3 serine 10 and increased binding of h...

journal_title：Cytokine

authors： Yoza BK,McCall CE

更新日期：2011-02-01 00:00:00

abstract：:Recent evidence indicates that the rate of progression of the HIV-1 disease is significantly reduced in thalassaemia major patients upon treatment with high doses of desferrioxamine (DFX). The authors have previously demonstrated that in vitro exposure of mononuclear cells to DFX decreases the bioavailability of tumou...

journal_title：Cytokine

authors： Bellocq A,Israël-Biet D,Cadranel J,Perez J,Fouqueray B,Kanfer A,Girot R,Baud L

更新日期：1999-02-01 00:00:00

abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

journal_title：Cytokine

authors： Behzad H,Jamil S,Denny TA,Duronio V

更新日期：2007-05-01 00:00:00

abstract：:Tenidap is a novel anti-inflammatory and anti-arthritic agent that lowers intracellular pH and suppresses anion transport when applied to cells in vitro. Both of these parameters are known to influence pro-inflammatory cell function. To investigate whether tenidap can modulate cellular responses to cytokine stimulatio...

journal_title：Cytokine

authors： McNiff PA,Laliberte RE,Svensson L,Pazoles CJ,Gabel CA

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...

journal_title：Cytokine

authors： Hu WL,Qiao SB,Li JJ

更新日期：2007-12-01 00:00:00

abstract：:High-fat-fed C57Bl/6J FABP4/aP2 null mice develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. FABP4/aP2 protein's function to bind fatty acids in the adipocytes may promote total body energy homeostasis by linking energy depots to the ability to express signaling m...

journal_title：Cytokine

authors： Witthuhn BA,Bernlohr DA

更新日期：2001-05-07 00:00:00

abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

journal_title：Cytokine

authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

更新日期：1996-09-01 00:00:00

abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...

journal_title：Cytokine

authors： Heymann D,Rousselle AV

更新日期：2000-10-01 00:00:00

abstract：:Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...

journal_title：Cytokine

authors： Zenti MG,Stefanutti C

更新日期：2011-12-01 00:00:00

abstract：:We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta1 (TGF-beta1) during bacterial pneumonia in rats. Immediately following IB Escherichia coli inoculation (T0), animals (n=270) were randomized to receive a single treatment with human recombinant ...

journal_title：Cytokine

authors： Cui X,Zeni F,Vodovitz Y,Correa-de-Araujo R,Quezado M,Roberts A,Wahl S,Danner RL,Banks SM,Gerstenberger E,Fitz Y,Natanson C,Eichacker PQ

更新日期：2003-11-21 00:00:00

abstract：RATIONALE:Sarcoidosis is an idiopathic granulomatous disorder with heterogeneous clinical manifestations and variable prognosis. Monitoring disease activity is important to identify patients requiring treatment. Several cytokines have previously been shown to be elevated in the serum of patients with sarcoidosis and ma...

journal_title：Cytokine

authors： Geyer AI,Kraus T,Roberts M,Wisnivesky J,Eber CD,Hiensch R,Moran TM

更新日期：2013-10-01 00:00:00

abstract：:A series of controlled clinical trials have shown that exogenous interferon-beta (IFN-β) benefits patients with relapsing-remitting multiple sclerosis (RRMS) by reducing relapse rate, disability progression, and the formation of new brain and spinal cord lesions on magnetic resonance imaging (MRI) scans. Unfortunately...

journal_title：Cytokine

authors： Huber AK,Duncker PC,Irani DN

更新日期：2015-08-01 00:00:00

abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

journal_title：Cytokine

authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

更新日期：2008-12-01 00:00:00

abstract：:Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...

journal_title：Cytokine

authors： Lubberts E

更新日期：2008-02-01 00:00:00