Abstract:
:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many factors involved in bone tissue metabolism have been found to be closely related to the inflammatory process. More recently, a cytokine family sharing a common signal transducer (gp130) had been identified, which appears to be a key factor in bone remodelling. This family includes interleukin 6, interleukin 11, oncostatin M, leukaemia inhibitory factor, ciliary neurotrophic factor and cardiotrophin-1. This paper provides an exhaustive review of recent knowledge on the involvement of gp130 cytokine family in bone cell (osteoblast, osteoclast, etc.) differentiation/activation and in osteoarticular pathologies.
journal_name
Cytokinejournal_title
Cytokineauthors
Heymann D,Rousselle AVdoi
10.1006/cyto.2000.0747keywords:
subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1455-68issue
10eissn
1043-4666issn
1096-0023pii
S1043-4666(00)90747-6journal_volume
12pub_type
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