当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > The conundrum of interferon-β non-responsiveness in relapsing-remitting multiple sclerosis.

The conundrum of interferon-β non-responsiveness in relapsing-remitting multiple sclerosis.

Abstract：

:A series of controlled clinical trials have shown that exogenous interferon-beta (IFN-β) benefits patients with relapsing-remitting multiple sclerosis (RRMS) by reducing relapse rate, disability progression, and the formation of new brain and spinal cord lesions on magnetic resonance imaging (MRI) scans. Unfortunately, however, the effectiveness of IFN-β is limited in this setting by the occurrence of treatment non-responsiveness in nearly 25% of patients. Furthermore, clinicians who care for RRMS patients remain unable to accurately identify IFN-β non-responders prior to the initiation of therapy, causing delays in the use of alternative treatments and sometimes requiring that patients turn to medications with more significant side effects to control their disease. Progress has been made toward understanding how both endogenous and exogenous IFN-β act to slow RRMS as well as the related mouse model, experimental autoimmune encephalomyelitis (EAE). Most studies point to its inhibitory actions on circulating immune cells as being important for suppressing both disorders, but multiple potential target cells and inflammatory pathways have been implicated and those essential to confer its benefits remain undefined. This review focuses on the role of both endogenous and exogenous IFN-β in RRMS, paying particular attention to the issue of why certain individuals appear refractory to its disease-modifying effects. A continued goal in this field remains the identification of a convenient biomarker that accurately predicts IFN-β treatment non-responsiveness in individual RRMS patients. Development of such an assay will allow clinicians to customize therapy for patients with this complex disorder.

journal_name

Cytokine

journal_title

Cytokine

authors

Huber AK,Duncker PC,Irani DN

doi

10.1016/j.cyto.2015.01.004

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

228-36

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(15)00008-3

journal_volume

74

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Low extracellular pH stimulates the production of IL-1β by human monocytes.

    abstract：:The development of acidic environments is a hallmark of inflammatory processes of different etiology. We have previously shown that transient exposure to acidic conditions, similar to those encountered in vivo, induces the activation of neutrophils and the phenotypic maturation of dendritic cells. We here report that ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.11.013

    authors： Jancic CC,Cabrini M,Gabelloni ML,Rodríguez Rodrigues C,Salamone G,Trevani AS,Geffner J

    更新日期：2012-02-01 00:00:00

  • Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults.

    abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.03.020

    authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

    更新日期：2011-07-01 00:00:00

  • Toll-like receptor signalling in liver disease: ER stress the missing link?

    abstract：:Toll-like receptors induce a complex inflammatory response that can function to alert the body to infection, neutralize pathogens and repair damaged tissues. Toll-like receptors are expressed on kupffer, endothelial, dendritic, biliary epithelial, hepatic stellate cells, and hepatocytes in the liver. The endoplasmic r...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2012.04.003

    authors： Lawless MW,Greene CM

    更新日期：2012-08-01 00:00:00

  • IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?

    abstract：:Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis. Data from experimental arthritis indicate IL-17 receptor signaling as a critical pathway in turning an acute synovitis into a chronic destructive arthritis. The identification of six IL-17 family members (IL-17A-F) may extend the role of this novel...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2007.09.014

    authors： Lubberts E

    更新日期：2008-02-01 00:00:00

  • TNF-α polymorphisms and coronary artery disease: association study in the Korean population.

    abstract：:Coronary artery disease (CAD) results from atherosclerosis, a chronic inflammatory disease mediated in part by proinflammatory cytokines, particularly tumor necrosis factor-α (TNF-α), which is expressed by atherosclerotic plaques. In this study, we investigated whether TNF-α gene promoter polymorphisms affect the inci...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.02.008

    authors： Cho HC,Yu G,Lee MY,Kim HS,Shin DH,Kim YN

    更新日期：2013-04-01 00:00:00

  • Glutathione depletion inhibits IL-1 beta-stimulated nitric oxide production by reducing inducible nitric oxide synthase gene expression.

    abstract：:L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibi...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0712

    authors： Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen T

    更新日期：2000-09-01 00:00:00

  • Serum levels of interleukin-2 predict the recurrence of atrial fibrillation after pulmonary vein ablation.

    abstract：AIMS:Interleukin-2 has a significant antitumor activity in some types of cancer, and has been associated with the development of atrial fibrillation (AF). In addition, IL-2 serum levels in recent onset AF have been related with pharmaceutical cardioversion outcomes. We evaluated the hypothesis that a relationship exist...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.026

    authors： Cabrera-Bueno F,Medina-Palomo C,Ruiz-Salas A,Flores A,Rodríguez-Losada N,Barrera A,Jiménez-Navarro M,Alzueta J

    更新日期：2015-05-01 00:00:00

  • Investigating T cell activation and tolerance in vivo: peptide challenge in allergic asthmatics.

    abstract：:In the atopic allergic individual, challenge with allergen elicits manifestations of both the humoral (IgE-mediated or early-phase reaction) and the cell-mediated immune response (late-phase reaction). Detailed study of late-phase cell-mediated events is confounded by the effects of the earlier IgE-mediated response w...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2004.07.001

    authors： Smith TR,Larché M

    更新日期：2004-10-21 00:00:00

  • The local liver ablation with pulsed electric field stimulate systemic immune reaction against hepatocellular carcinoma (HCC) with time-dependent cytokine profile.

    abstract：AIM:How irreversible electroporation (IRE) affect immune status is still kept unknown. This preclinical study is to investigate its local and systemic immune reaction both on tumor-bearing and tumor free animals. METHODS:Liver ablation was performed by a standard IRE instrument and proposal. Altogether 57 tumor bearin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2017.05.003

    authors： Chen X,Ren Z,Yin S,Xu Y,Guo D,Xie H,Zhou L,Wu L,Jiang J,Li H,Sun J,Zheng S

    更新日期：2017-05-01 00:00:00

  • Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients.

    abstract：:Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explor...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.01.012

    authors： Santinelli L,Statzu M,Pierangeli A,Frasca F,Bressan A,Pinacchio C,Nonne C,Turriziani O,Antonelli G,d'Ettorre G,Scagnolari C

    更新日期：2019-08-01 00:00:00

  • The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice.

    abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.09.007

    authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

    更新日期：2010-02-01 00:00:00

  • Effect of MG132, a proteasome inhibitor, on the expression of growth related oncogene protein-alpha in human umbilical vein endothelial cells.

    abstract：:Growth related oncogene protein-alpha (GRO-alpha) is a member of C-X-C chemokine and plays an important role in inflammatory responses. Expression of GRO gene family is regulated by a number of factors at both transcriptional and posttranscriptional levels. In the present study, we have addressed the possible regulati...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00271-0

    authors： Shibata T,Imaizumi T,Matsumiya T,Tamo W,Hatakeyama M,Yoshida H,Munakata H,Fukuda I,Satoh K

    更新日期：2003-11-07 00:00:00

  • The interferon-induced gene ISG12 is regulated by various cytokines as the gene 6-16 in human cell lines.

    abstract：:The gene for ISG12 (originally designated p27) was isolated as an oestrogen-induced gene. The authors undertook a comprehensive study using quantitative RT-PCR, in which we delineate the regulation of ISG12 by seven different cytokines including interferons and poly(I). poly(C) in seven human cell lines of different o...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0549

    authors： Gjermandsen IM,Justesen J,Martensen PM

    更新日期：2000-03-01 00:00:00

  • IL17 and IFNgamma production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis.

    abstract：:We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.08.007

    authors： Frisullo G,Nociti V,Iorio R,Patanella AK,Marti A,Caggiula M,Mirabella M,Tonali PA,Batocchi AP

    更新日期：2008-10-01 00:00:00

  • IL-10 promotes resistance to apoptosis and metastatic potential in lung tumor cell lines.

    abstract：:Treatment of non-small cell lung carcinoma (NSCLC) remains at a disappointingly low success rate. Not only is metastatic spread common in NSCLC, but therapeutic success decreases dramatically once metastases are present. Understanding factors which contribute to poor prognosis in NSCLC is critical for development of m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.11.015

    authors： Zeng L,O'Connor C,Zhang J,Kaplan AM,Cohen DA

    更新日期：2010-03-01 00:00:00

  • Interleukin-10 regulates arterial pressure in early primate pregnancy.

    abstract：OBJECTIVES:In pregnancy, the placental contribution of cytokines to maternal immunosuppression has been established, however their role in normal maternal blood pressure regulation has not been identified. We investigate the contribution of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) to the vasod...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.10.011

    authors： Orange S,Rasko JE,Thompson JF,Vaughan J,Olive E,Pedler M,Horvath JS,Hennessy A

    更新日期：2005-02-21 00:00:00

  • Comparative dose-responses of recombinant human IL-2 and IL-7 on STAT5 phosphorylation in CD4+FOXP3- cells versus regulatory T cells: a whole blood perspective.

    abstract：:Interleukin(IL)-2 and IL-7 are cytokines with important functions related to CD4(+) lymphocyte proliferation, differentiation and survival. Depending on doses, they theoretically activate regulatory (Treg) and/or effector T cells (Teff) and thus may be indicated with different therapeutic objectives. In this study we ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.05.021

    authors： Dupont G,Demaret J,Venet F,Malergue F,Malcus C,Poitevin-Later F,Morel J,Monneret G

    更新日期：2014-09-01 00:00:00

  • Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects.

    abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.12.012

    authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

    更新日期：2019-04-01 00:00:00

  • The effect of ether lipid 1-O-octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine and its analogues platelet activating factor and carbamyl-platelet activating factor on the biosynthesis of interleukin-6 in human thymic epithelial cells cultivated in vitro

    abstract：:The effect of ether lipid 1-O-Octadecyl-2-O-methoxy-rac-glycero-3-phosphocholine (ET-18-OCH3), platelet activating factor (PAF) and carbamyl activating factor (CPAF) on the release of IL-6 in human thymic epithelium cultivated in vitro was studied. ET-18-OCH3 significantly increased the release of IL-6, giving the gre...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0092

    authors： Cardile V,Mascarucci P,De Simoni MG,Jiang X,Bindoni M

    更新日期：1996-09-01 00:00:00

  • Cytokines in liposomes: preliminary studies with IL-1, IL-2, IL-6, GM-CSF and interferon-gamma.

    abstract：:A simple, generally applicable method to incorporate cytokine proteins into multilamellar liposomes is presented. A variety of human cytokines including granulocyte-macrophage colony stimulating factor (GM-CSF), interleukins 1 alpha, 2 and 6 (IL-1 alpha, IL-2, IL-6) and interferon-gamma (IFN-gamma) were incorporated i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90014-0

    authors： Anderson PM,Hanson DC,Hasz DE,Halet MR,Blazar BR,Ochoa AC

    更新日期：1994-01-01 00:00:00

  • Transcutaneous IL-2 uptake mediated by Transfersomes depends on concentration and fractionated application.

    abstract：INTRODUCTION:Transfersomes (TF) are new, ultradeformable carriers with characteristics that enable them to penetrate the skin spontaneously. TFs are able to transport noninvasively both low- and high-molecular-weight molecules into the body. MATERIALS AND METHODS:TFs contain phosphatidylcholine and sodium cholate. Rec...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2003.10.010

    authors： Hofer C,van Randenborgh H,Lehmer A,Hartung R,Breul J

    更新日期：2004-02-21 00:00:00

  • Function of the human interleukin 4 receptor (IL-4R)-derived acidic motif revealed by cytoplasmic domain chimeras of the IL-4R alpha chain and the IL-2R beta chain.

    abstract：:Interleukin 2 (IL-2)- and IL-4-mediated stimulation of survival and growth, reflected by the induction of bcl2 and c-myc, respectively, depends on the integrity of the membrane-proximal region (S-region) in the IL-2 receptor beta-chain (IL-2R beta) and the haematopoietin homology box1-containing region of the IL-4 rec...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0293

    authors： Deutsch HH,Chung J,Kalthoff FS

    更新日期：1998-05-01 00:00:00

  • The effect of endurance training and downhill running on the expression of IL-1β, IL-6, and TNF-α and HSP72 in rat skeletal muscle.

    abstract：:This study investigated changes in the myokines IL-1β, IL-6, and TNF-α, as well as HSP72, after endurance training and after a session of downhill running. Twenty-eight rats were allocated to four different groups: 1. Eight weeks of endurance training at 65-70% VO2max (Trained); 2. Endurance training and a single sess...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.03.013

    authors： Isanejad A,Saraf ZH,Mahdavi M,Gharakhanlou R,Shamsi MM,Paulsen G

    更新日期：2015-06-01 00:00:00

  • IL-17A versus IL-17F induced intracellular signal transduction pathways and modulation by IL-17RA and IL-17RC RNA interference in AGS gastric adenocarcinoma cells.

    abstract：:Inflammatory processes are implicated in gastric cancer development. In contrast, the role of inflammation and proinflammatory cytokines in established cancer remains to be clarified. We investigated the contribution of IL-17A versus IL-17F-mediated intracellular signalling pathways in human gastric adenocarcinoma AGS...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.06.002

    authors： Zhou Y,Toh ML,Zrioual S,Miossec P

    更新日期：2007-06-01 00:00:00

  • Interleukin-6 and perioperative thermoregulation and HPA-axis activation.

    abstract：:Surgery is followed by an acute-phase response, including hypothalamo-pituitary-adrenal (HPA)-axis activation and fever. Considering its physiological properties and its behaviour in plasma after stress and surgery, the pro-inflammatory cytokine interleukin (IL)-6 is a putative candidate in eliciting these stress-rela...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00093-0

    authors： De Jongh RF,Vissers KC,Booij LH,De Jongh KL,Vincken P,Meert TF

    更新日期：2003-03-07 00:00:00

  • Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.

    abstract：:Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.06.006

    authors： Bartee E,McFadden G

    更新日期：2009-09-01 00:00:00

  • Co-culture of human monocytes and thyrocytes in bicameral chamber: monocyte-derived IL-1alpha impairs the thyroid epithelial barrier.

    abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0523

    authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

    更新日期：2000-01-01 00:00:00

  • Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population.

    abstract：OBJECTIVE:Brain abscess develops in response to a parenchymal infection with pyogenic bacteria. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are the most crucial pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. The present study evaluated the assoc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.07.009

    authors： Mishra P,Prasad KN,Singh K,Bajpai A,Sahu RN,Ojha BK

    更新日期：2015-09-01 00:00:00

  • IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract：:An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypert...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.02.008

    authors： Kim HY,Kim HS

    更新日期：2014-07-01 00:00:00

  • Role of inflammatory gene polymorphisms in left ventricular dysfunction (LVD) susceptibility in coronary artery disease (CAD) patients.

    abstract：RATIONALE:Inflammation exacerbates a number of deleterious effects on the heart, most notable being left ventricular dysfunction (LVD). A promoter polymorphism of the NFKB1 gene (encodes p50 subunit) results in lower protein levels of NFkB p50 subunits, which in its dimmer (p50) form has anti-inflammatory effects. The ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.12.020

    authors： Mishra A,Srivastava A,Mittal T,Garg N,Mittal B

    更新日期：2013-03-01 00:00:00