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Tumor necrosis factor-α and interleukin-1β gene polymorphisms and risk of brain abscess in North Indian population.

Abstract：

OBJECTIVE:Brain abscess develops in response to a parenchymal infection with pyogenic bacteria. Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are the most crucial pro-inflammatory cytokines with both beneficial and destructive properties for the central nervous system. The present study evaluated the association of specific alleles/genotypes of TNF-α and IL-1β with brain abscess. MATERIAL AND METHODS:A total of 90 brain abscess patients and 100 healthy controls were included in the study. Predisposing factors were identified in 56 (62.2%) patients with brain abscess. TNF-α (-308 G>A) and IL-1β (-511 CA) and C allele in IL-1β (-511 CA) and IL-1β (-511 C

journal_name

Cytokine

journal_title

Cytokine

authors

Mishra P,Prasad KN,Singh K,Bajpai A,Sahu RN,Ojha BK

doi

10.1016/j.cyto.2015.07.009

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

159-64

issue

1

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(15)30019-3

journal_volume

75

pub_type

杂志文章

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