Abstract:
:L-buthionine-S,R-sulfoximine (BSO), an inhibitor of GSH synthesis, decreased IL-1 beta-induced nitrite release in rat islets and purified rat beta cells, nitrite formation and iNOS gene promoter activity in insulinoma cells, and iNOS mRNA expression in rat islets. The thiol depletor diethyl maleate (DEM) and an inhibitor of glutathione reductase 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) reduced IL-1 beta-stimulated nitrite release in islets. We conclude that GSH regulates IL-1 beta-induced NO production in islets, purified beta cells and insulinoma cells by modulation of iNOS gene expression.
journal_name
Cytokinejournal_title
Cytokineauthors
Nikulina MA,Andersen HU,Karlsen AE,Darville MI,Eizirik DL,Mandrup-Poulsen Tdoi
10.1006/cyto.2000.0712keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1391-4issue
9eissn
1043-4666issn
1096-0023pii
S1043-4666(00)90712-9journal_volume
12pub_type
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