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Intracellular regulation of TNF activity in health and disease.

Abstract：

:Tumor Necrosis Factor alpha (TNFα, TNF) is a key mediator and regulator of mammalian immune responses in healthy organisms and in diseased conditions. TNF governs development of the immune system, cell survival signaling pathways, proliferation and regulates metabolic processes. Whereas TNF-induced NF-κB and MAP pro-survival kinase activities constitute its major biochemical functions, TNF can also stimulate cell death in certain pathological situations. TNF-induced signal transduction pathways are tightly regulated through ubiquitination and phosphorylation of molecules partaking in all TNF-dependent membrane-associated and intracellular protein signaling complexes. Deregulated TNF signaling in individuals carrying naturally occurring genetic mutations in proteins that mediate TNF signaling, or in corresponding genetically modified animal models, results in severe pathologies. In this review we will describe the current knowledge of TNF signaling and its relevance for human health.

journal_name

Cytokine

journal_title

Cytokine

authors

Varfolomeev E,Vucic D

doi

10.1016/j.cyto.2016.08.035

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

26-32

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(16)30489-6

journal_volume

101

pub_type

杂志文章,评审

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