Abstract：
:The chemokine eotaxin (CCL11) is a key player in the trafficking of eosinophils to normal tissues and in the tissue eosinophilia associated with human allergic disease. We have recently cloned equine eotaxin and here we report the production of rEq eotaxin, with and without a C-terminal fusion peptide, in a novel expression system utilising stably transfected insect cells. rEq eotaxin induced equine eosinophil migration and superoxide production in vitro. A shape change in human eosinophils that could be blocked by 7B11, a monoclonal antibody against human CCR3, was also observed. Biological activity was not dependent on an intact eotaxin C-terminus. These results suggest that equine eotaxin, like its human ortholog, may play a role in eosinophil accumulation and activation in the horse.
journal_name
Cytokinejournal_title
Cytokineauthors
Benarafa C,Collins ME,Hamblin AS,Sabroe I,Cunningham FMdoi
10.1006/cyto.2002.1052keywords:
subject
Has Abstractpub_date
2002-07-07 00:00:00pages
27-30issue
1eissn
1043-4666issn
1096-0023pii
S1043466602910525journal_volume
19pub_type
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