Abstract：
:Antigen (Ag)-stimulated mast cells induce synthesis and production of cytokines including tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 with proinflammatory and immune regulatory properties. Expression of TNF-alpha and IL-6 was regulated by a transcription factor, nuclear factor (NF)-kappaB. The iridoid glycoside, aucubin, has been found as a natural constituent of many traditional oriental medicinal plants. We studied the effect of aucubin on the TNF-alpha and IL-6 expression in Ag-stimulated rat basophilic leukemia (RBL)-2H3 mast cells. We show that aucubin inhibited Ag-induced TNF-alpha and IL-6 production and expression in a dose-dependent manner with IC(50) of 0.101 and 0.19 microg/ml, respectively. Maximal inhibition of TNF-alpha and IL-6 production was 73 +/- 4.3% and 88.8 +/- 5%, respectively. Aucubin also inhibited Ag-induced nuclear translocation of p65 subunit of NF-kappaB and degradation of IkappaBalpha. Inhibition of NF-kappaB activation by aucubin might be specific since activator protein-1 binding activity was not affected. In conclusion, these results suggest that aucubin is a specific inhibitor of NF-kappaB activation in mast cells, which might explain its beneficial effect in the treatment of chronic allergic inflammatory diseases.
journal_name
Cytokinejournal_title
Cytokineauthors
Jeong HJ,Koo HN,Na HJ,Kim MS,Hong SH,Eom JW,Kim KS,Shin TY,Kim HMdoi
10.1006/cyto.2002.0894keywords:
subject
Has Abstractpub_date
2002-06-07 00:00:00pages
252-9issue
5eissn
1043-4666issn
1096-0023pii
S104346660290894Xjournal_volume
18pub_type
杂志文章相关文献
CYTOKINE文献大全abstract：:Therapeutic plasmapheresis is a recognized medical procedure in which various techniques are used to separate and remove undesirable or excessively elevated plasma elements from blood. The main purpose of the procedure is to remove the substances responsible for the disease (autoantibodies, circulating immune complexe...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2011.08.038
更新日期：2011-12-01 00:00:00
abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1997.0281
更新日期：1998-03-01 00:00:00
abstract：:Overweight and obesity are associated with chronic and subclinical inflammation due to an imbalance of inflammatory mediators. However, the association with gene polymorphism has been rarely studied in children. The aim of this study was to determine if serum concentrations of C-reactive protein (CRP) and interleukin-...
journal_title：Cytokine
pub_type： 临床试验,杂志文章
doi：10.1016/j.cyto.2016.09.007
更新日期：2016-12-01 00:00:00
abstract：:The gene for C10, a member of the beta-chemokine family of cytokines, contains a novel second exon encoding a 16 amino acid sequence which is inserted into the amino-terminal region of the protein. We propose a model of C10 structure in which the sequence encoded by the second exon is located on the surface of the pro...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1996.0060
更新日期：1996-06-01 00:00:00
abstract：:Cytokine induction following stimulation by endotoxin (LPS) was investigated in human peripheral whole blood. Blood cells were suspended in autologous plasma diluted in basal medium (BM-plasma) or Compound Sodium Lactate Solution (CSL-plasma), or in autologous serum diluted in CSL. Induction of interleukin 1 beta, int...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(94)90020-5
更新日期：1994-05-01 00:00:00
abstract：:Large amounts of anti-inflammatory mediators, such as interleukin (IL)-10, are produced and found early in the course of sepsis. We explore the role of IL-10 on neutrophil (PMN) activation/function using an in vitro model. Isolated human PMN were pre-incubated with lipopolysaccharide (LPS) and/or IL-10 for 18h. Subseq...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2013.03.025
更新日期：2013-06-01 00:00:00
abstract：:In order to study structure-function relationships of the M(r) 55,000 subunit of the murine IL-2R (p55 IL-2R) by epitope mapping, we have expressed the p55 IL-2R molecule in a cell-free translation system. Under these in vitro conditions, we detected the expected p55 IL-2R polypeptide initiated at Met 1 and, in additi...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(92)90066-z
更新日期：1992-07-01 00:00:00
abstract：:Interleukin (IL)-7 stimulation improves virus- and tumor-specific CD8+ T cell responses. However, the role of IL-7 in modulation of dysfunctional CD8+ T cells in hepatocellular carcinoma (HCC) was not completely understood. In this study, a total of 37 HLA-A2 restricted patients with HCC and 16 healthy individuals wer...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2018.04.003
更新日期：2019-06-01 00:00:00
abstract：:The evolution of malignant cells implies an increase in oncogenic fitness of cells which arises in active and reciprocal interaction with the tumor microenvironment. The mechanisms facilitating the adaptive evolution of cancer cells involve clonal selection of cancer cells, in a direction of increased adaptive potenti...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2021.155442
更新日期：2021-01-25 00:00:00
abstract：BACKGROUND:The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels o...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2020.155223
更新日期：2020-11-01 00:00:00
abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2005.06.008
更新日期：2005-09-07 00:00:00
abstract：:Antibiotic therapy is only moderately efficacious for bovine Staphylococcus aureus mastitis. We have used recombinant bovine cytokines to activate the natural host defenses, to prevent and treat bovine mastitis. Uninfected mammary glands infused with GM-CSF or IL-2 increased the percentage of phagocytic cells in the m...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/1043-4666(93)90015-w
更新日期：1993-05-01 00:00:00
abstract：:There is considerable variability in the concentrations of transforming growth factor beta (TGFbeta) in human milk from individual women which is not readily explained by maternal factors such as smoking or illness. A potential correlate is the maternal plasma level of TGFbeta since changes in plasma concentration of ...
journal_title：Cytokine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1006/cyto.2002.0987
更新日期：2002-02-21 00:00:00
abstract：:Along with several other aspects of Chagas disease, the mechanisms responsible for the different clinical outcomes observed in chronic infected individuals have not yet been clarified. It is believed that the host immune response to the parasite plays an important role in the development of the pathology. Therefore, t...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2012.01.008
更新日期：2012-05-01 00:00:00
abstract：:The TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily that has been recognized for its specific pro-apoptotic effect on cancer cells and has been therefore proposed as a treatment in cancer. Studies on animal models have shown that TRAIL could also have a benefici...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2013.04.011
更新日期：2013-08-01 00:00:00
abstract：UNLABELLED:Burn is associated with profound inflammation and activation of the innate immune system in multiple organ beds, including the lung. Similarly, toll-like receptors (TLR) are associated with innate immune activation. Nonetheless, it is unclear what impact burn has on TLR-induced inflammatory responses in the ...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2011.05.004
更新日期：2011-09-01 00:00:00
abstract：:Helminths and their products have a profound immunomodulatory effect upon the inductive and effector phases of inflammatory responses, including allergy. We have demonstrated that PAS-1, a protein isolated from Ascaris suum worms, has an inhibitory effect on lung allergic inflammation due to its ability to down-regula...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2008.09.005
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:This study evaluates the potential of gingival crevicular fluid and serum cytokines as HIV stage biomarkers. METHODS:Gingival crevicular fluid (GCF) and serum samples from 78 HIV-positive adult male subjects (cases) and 39 HIV-negative male subjects (controls) from Mexico were examined for 17 cytokines using...
journal_title：Cytokine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.cyto.2016.12.019
更新日期：2017-03-01 00:00:00
abstract：:Bone tissue is continually being remodelled according to physiological circumstances. Two main cell populations (osteoblasts and osteoclasts) are involved in this process, and cellular activities (including cell differentiation) are modulated by hormones, cytokines and growth factors. Within the last 20 years, many fa...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1006/cyto.2000.0747
更新日期：2000-10-01 00:00:00
abstract：:Myeloma is a neoplasm thought to "home" to bone marrow. However, evidence for bone-marrow-specific receptors or adhesion molecules expressed on myeloma cells is scanty. Initial myeloma expansion is thought to be due to IL-6 and/or related cytokines. Previous determinations of cytokine expression in bone marrow were pe...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.2000.0748
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND:Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis in rodents, while its role in humans is unclear. C-reactive protein (CRP) is an important risk predictor for coronary heart disease, and it can also modify the expression of genes involved...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.09.011
更新日期：2007-12-01 00:00:00
abstract：:To verify the role of macrophage migration inhibitory factor (MIF) in tumourigenesis, we examined the effect of an anti-MIF antibody on tumour growth and angiogenesis. We inoculated murine colon adenocarcinoma cell line colon 26 cells subcutaneously into the flank in BALB/c mice. After nine days, we treated tumour-bea...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1006/cyto.1999.0562
更新日期：2000-04-01 00:00:00
abstract：:The clinical spectrum of leishmaniasis depends on several factors, including Leishmania species and immunogenetic factors. Tumor necrosis factor α (TNFα) plays a central role in immunity against intracellular infections. Many studies have reported that TNFα-308G > A polymorphism is associated with susceptibility to in...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2021.155437
更新日期：2021-01-24 00:00:00
abstract：:There are limited and conflicting studies investigating the role of the angiopoietin family in human thyroid cancer development and progression. We have investigated cytokines angiopoietin-1, -2 and their receptor (Tie-2), known to be involved in angiogenesis, in the serum of 52 thyroid cancer patients (21 cases of pa...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2007.02.008
更新日期：2006-12-01 00:00:00
abstract：:Cytokines are involved in the pathogenesis of community acquired pneumonia (CAP). The aim of this study is to investigate the association of IL6-174 G/C gene polymorphism with CAP in Egyptian children, to assess its effect on CAP outcome and to determine its effect on the serum IL6 levels in these children. IL6-174 G/...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2014.02.013
更新日期：2014-06-01 00:00:00
abstract：:An accurate and simultaneous estimate of cellular levels of a large cytokine number is very useful to obtain information about an organ dysfunction leading to cancer because through the understanding of the evolution of cytokine patterns we can recognize and predict the disease progression. Cancer cell lines are commo...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2013.09.002
更新日期：2013-11-01 00:00:00
abstract：:Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2009.07.007
更新日期：2009-10-01 00:00:00
abstract：:D-dopachrome tautomerase (D-DT) is a newly described cytokine and a member of the macrophage migration inhibitory factor (MIF) protein superfamily. MIF is a broadly expressed pro-inflammatory cytokine that regulates both the innate and the adaptive immune response. MIF activates the MAP kinase cascade, modulates cell ...
journal_title：Cytokine
pub_type： 杂志文章,评审
doi：10.1016/j.cyto.2012.03.014
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To examine the expression of chemokine receptors in different peripheral blood T-cell subsets in patients with polymyositis (PM) and dermatomyositis (DM). METHODS:We used flow cytometry to measure the frequencies of chemokinereceptors CXCR3 and CCR4 expression in the CD4+ or CD8+ lymphocytes. Enzyme linked i...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2017.08.018
更新日期：2017-11-01 00:00:00
abstract：:Given the known anti-tumorigenic properties of IFNγ, its effect on glioma cell survival was investigated. Though IFNγ had no effect on glioma cell viability, it induced cell cycle arrest. This was accompanied by increased expression of p53 and retinoic acid inducible gene (RIG-I). While RIG-I had no effect on glioma c...
journal_title：Cytokine
pub_type： 杂志文章
doi：10.1016/j.cyto.2015.10.009
更新日期：2017-01-01 00:00:00
