Prevention and treatment of Staphylococcus aureus infections with recombinant cytokines.

abstract：:A well-known association between vitamin D(3) and infection with Mycobacterium tuberculosis has previously been reported, but little is known regarding the underlying mechanisms. We have investigated how 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] affects the proinflammatory cytokine production induced by M. tubercul...

journal_title：Cytokine

authors： Khoo AL,Chai LY,Koenen HJ,Oosting M,Steinmeyer A,Zuegel U,Joosten I,Netea MG,van der Ven AJ

更新日期：2011-08-01 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...

journal_title：Cytokine

authors： Oishi K,Mimura-Kimura Y,Miyasho T,Aoe K,Ogata Y,Katayama H,Murata Y,Ueoka H,Matsumoto T,Mimura Y

更新日期：2013-01-01 00:00:00

abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...

journal_title：Cytokine

authors： Chou TH,Chuang CY,Wu CM

更新日期：2010-07-01 00:00:00

abstract：:The present study aims to characterize the role of the citrulline-nitric oxide cycle in the response of adult human and rat pancreatic islets to cytokines. Citrulline (0.1-1.0 mM) or arginine (0.1-1.0 mM) led to a similar dose dependent nitric oxide (NO) production by rat islets exposed to interleukin 1 beta (IL-1 bet...

journal_title：Cytokine

authors： Flodström M,Morris SM Jr,Eizirik DL

更新日期：1996-08-01 00:00:00

abstract：:Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

journal_title：Cytokine

authors： Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

更新日期：1992-09-01 00:00:00

abstract：:Estrogens have been shown to markedly modulate the immune system. One mechanism by which estrogens could modulate the immune system is by regulating cytokines, an aspect not well-studied thus far. To address this issue, normal C57BL/6 orchiectomized mice were given estrogen and its effects on selected cytokines, inter...

journal_title：Cytokine

authors： Karpuzoglu-Sahin E,Zhi-Jun Y,Lengi A,Sriranganathan N,Ansar Ahmed S

更新日期：2001-05-21 00:00:00

abstract：:The functions of phagocytic cells against pathogens are initiated by the interaction between membrane receptors and molecular structures which compose the cell wall of these microorganisms. Thus our study aimed to identify the neutrophil receptors involved in the recognition of different strains of Paracoccidioides br...

journal_title：Cytokine

authors： Balderramas HA,Penitenti M,Rodrigues DR,Bachiega TF,Fernandes RK,Ikoma MR,Dias-Melicio LA,Oliveira SL,Soares ÂM

更新日期：2014-05-01 00:00:00

abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

journal_title：Cytokine

authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

更新日期：2019-03-01 00:00:00

abstract：:This study was designed to compare the effect of Aspirin (AS) and Nimesulide (NM) on renal failure and vascular disorder in streptozotocin (STZ)-induced diabetic rats. Rats were divided into four groups; control, diabetic rats, diabetic rats plus AS and diabetic rats plus NM, which are COX inhibitors. The renal and ao...

journal_title：Cytokine

authors： Yesilot S,Ozer MK,Bayram D,Oncu M,Karabacak HI,Cicek E

更新日期：2010-12-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is an immune disease in which the pathological immune reaction is thought to be initiated by the presentation of an (auto) antigen or superantigen by MHC class II positive cells to CD4 T cells. These successive immunological events can be studied by the cytokines produced at the different sta...

journal_title：Cytokine

authors： Zangerle PF,De Groote D,Lopez M,Meuleman RJ,Vrindts Y,Fauchet F,Dehart I,Jadoul M,Radoux D,Franchimont P

更新日期：1992-11-01 00:00:00

abstract：:MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition ...

journal_title：Cytokine

authors： Alosaimi B,Hamed ME,Naeem A,Alsharef AA,AlQahtani SY,AlDosari KM,Alamri AA,Al-Eisa K,Khojah T,Assiri AM,Enani MA

更新日期：2020-02-01 00:00:00

abstract：:Previous studies identified the variant IFNG +874A/T (rs2430561) in the first intron of the gene in association with mycobacterial infection, especially tuberculosis and leprosy. The aim of this investigation was to analyze the protective role of the T allele in relation to leprosy using a meta-analysis evaluation. Th...

journal_title：Cytokine

authors： Silva GA,Naveca FG,Ramasawmy R,Boechat AL

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:The clinical symptoms of the patients with intracellular bacterial bloodstream infections (Intra-bac BSIs) are atypical, and no early and accurate diagnostic biomarkers exist, which can easily lead to misdiagnosis, inappropriate and delayed treatment. Therefore, it is imperative to find novel biomarkers to h...

journal_title：Cytokine

authors： Lin MF,Sun B,Liu ZY,Tang P,Zhang LJ,Wang YY

更新日期：2020-12-01 00:00:00

abstract：:Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090...

journal_title：Cytokine

authors： Buraczynska M,Zukowski P,Drop B,Baranowicz-Gaszczyk I,Ksiazek A

更新日期：2016-03-01 00:00:00

abstract：:We examined the possible alteration of circulating transforming growth factor-beta1 (TGF-beta1) concentrations in a time-dependent fashion in human plasma. Plasma TGF-beta1 was measured three times at 2 week-intervals from each of 12 healthy participants. Platelet factor 4 (PF4) was measured in parallel with TGF-beta1...

journal_title：Cytokine

authors： Jeon JH,Kim YS,Choi EJ,Cheon S,Kim S,Kim JS,Jang JS,Ha WS,Park ST,Park CS,Park K,Park BK

更新日期：2001-11-07 00:00:00

abstract：:Interferon-gamma (IFN-gamma) is a potent immunomodulatory cytokine whose physiological roles are modulated by the extracellular matrix. Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secon...

journal_title：Cytokine

authors： Balasubramanian V,Ramanathan M

更新日期：2000-05-01 00:00:00

abstract：:The purpose of this study was to clone and characterize the bovine IL-1rII. Using a human IL-1rII probe, three putative exons of the bovine IL-1rII were identified from a bovine genomic library. The full length cDNA for bovine IL-1rII was cloned from a bovine endometrial cDNA library using oligonucleotides designed fr...

journal_title：Cytokine

authors： Yu PW,Chen HT,Czuprynski CJ,Schuler LA

更新日期：1997-01-01 00:00:00

abstract：:Malignant ascites of epithelial ovarian cancer patients contains high levels of interleukin 6 (IL-6). The present study was conducted to compare the secretion of IL-6 by seven different human ovarian cancer cell lines (OVCA) and cultured human peritoneal mesothelial cells (HPMC) and to examine the regulation of its pr...

journal_title：Cytokine

authors： Offner FA,Obrist P,Stadlmann S,Feichtinger H,Klingler P,Herold M,Zwierzina H,Hittmair A,Mikuz G,Abendstein B

更新日期：1995-08-01 00:00:00

abstract：:Ocular trauma affects 20% of Americans in their lifetime and can cause permanent visual system damage. We have used a mouse model of ocular trauma (exposure to an air blast from a paintball gun) to examine pathways that trigger the resulting retinal damage and to develop treatment strategies that might ameliorate the ...

journal_title：Cytokine

authors： Jiang Y,Pagadala J,Miller DD,Steinle JJ

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

journal_title：Cytokine

authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

更新日期：2017-03-01 00:00:00

abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief. Image duplication has been observed within Figure 1g-h. The corresponding author has been a...

journal_title：Cytokine

authors： Galloway C,Chattopadhyay M

更新日期：2013-07-01 00:00:00

abstract：:The full-length equine interferon-gamma (eIFN-gamma) cDNA, including the secretion signal peptide coding region, was recloned into baculovirus transfer vector pAcYM1. This vector was co-transfected with Autographa californica nuclear polyhedrosis virus DNA or hybrid nuclear polyhedrosis virus DNA into Spodoptera frugi...

journal_title：Cytokine

authors： Wu D,Murakami K,Liu N,Inoshima Y,Yokoyama T,Kokuho T,Inumaru S,Matsumura T,Kondo T,Nakano K,Sentsui H

更新日期：2002-10-21 00:00:00

abstract：:The authors evaluated the relationship between hormonal and cytokine responses after surgery. Patients who underwent thoracic oesophagectomy (O group; n = 7), pulmonary lobectomy (P group; n = 5), modified mastectomy (M group; n = 5) and laparoscopic cholecystectomy (LC group; n = 7), were randomly selected. Circulati...

journal_title：Cytokine

authors： Yamauchi H,Kobayashi E,Yoshida T,Kiyozaki H,Hozumi Y,Kohiyama R,Suminaga Y,Sakurabayashi I,Fujimura A,Miyata M

更新日期：1998-07-01 00:00:00

abstract：:Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...

journal_title：Cytokine

authors： El-Kadiry AE,Rafei M

更新日期：2019-08-01 00:00:00

abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

journal_title：Cytokine

authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

更新日期：1991-09-01 00:00:00

abstract：:We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...

journal_title：Cytokine

authors： Turpaev K,Litvinov D,Justesen J

更新日期：2003-07-01 00:00:00

abstract：:Since its first description in 1966, macrophage migration inhibitory factor (MIF) was found to play a critical role in inflammatory and immune responses as well as in disease pathogenesis especially in tumor pathogenesis and cancer progression. MIF is expressed in different cell types and is associated with many disea...

journal_title：Cytokine

authors： Adzavon YM,Zhao P,Lv B,Liu M,Zhang X,Xie F,Yang L,Shang L,Zhang M,Li Q,Ma X

更新日期：2017-09-01 00:00:00

abstract：:Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...

journal_title：Cytokine

authors： Dugas B,Dugas N,Conti M,Calenda A,Pino P,Thomas Y,Mazier D,Vouldoukis I

更新日期：2003-03-21 00:00:00

abstract：:To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulat...

journal_title：Cytokine

authors： Denizot Y,Karoutsos S,Nathan N

更新日期：2001-03-07 00:00:00

abstract：:The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to...

journal_title：Cytokine

authors： Paul WE

更新日期：2015-09-01 00:00:00