当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract.

MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in the lower respiratory tract.

Abstract：

:MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and disease outcome. However, CD4+ T-cell induced immune responses during acute MERS-CoV infection are barely detectable, with potent inhibition of effector T cells and downregulation of antigen presentation. The local pulmonary immune response, particularly the Th1 and Th2-related immune response during acute severe MERS-CoV infection is not fully understood. In this study, we offer the first insights into the pulmonary gene expression profile of Th1 and Th2-related cytokines/chemokines (Th1 & Th2 responses) during acute MERS-CoV infection using RT2 Profiler PCR Arrays. We also quantified the expression level of primary inflammatory cytokines/chemokines. Our results showed a downregulation of Th2, inadequate (partial) Th1 immune response and high expression levels of inflammatory cytokines IL-1α and IL-1β and the neutrophil chemoattractant chemokine IL-8 (CXCL8) in the lower respiratory tract of MERS-CoV infected patients. Moreover, we identified a high viral load in all included patients. We also observed a correlation between inflammatory cytokines, Th1, and Th2 downregulation and the case fatality rate. Th1 and Th2 response downregulation, high expression of inflammatory cytokines, and high viral load may contribute to lung inflammation, severe infection, the evolution of pneumonia and ARDS, and a higher case fatality rate. Further study of the molecular mechanisms underlying the Th1 and Th2 regulatory pathways will be vital for active vaccine development and the identification of novel therapeutic strategies.

journal_name

Cytokine

journal_title

Cytokine

authors

Alosaimi B,Hamed ME,Naeem A,Alsharef AA,AlQahtani SY,AlDosari KM,Alamri AA,Al-Eisa K,Khojah T,Assiri AM,Enani MA

doi

10.1016/j.cyto.2019.154895

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

154895

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(19)30324-2

journal_volume

126

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • Combination interleukin-2 and interleukin-12 induces severe gastrointestinal toxicity and epithelial cell apoptosis in mice.

    abstract：:Interleukin 2 (IL-2) and interleukin 12 (IL-12) have potent anti-tumour activity as single agent therapy against several different murine and human tumours. Combining these cytokines may result in improved therapeutic effectiveness, however, the toxicity associated with simultaneous administration is prohibitive. This...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0986

    authors： Kaufman HL,Swartout BG,Hörig H,Lubensky I

    更新日期：2002-01-07 00:00:00

  • The -251A>T polymorphism of interleukin-8 is associated with longer mechanical ventilation and hospital staying after coronary surgery.

    abstract：BACKGROUND:Cardiac surgery is associated with inflammatory responses that are known to affect its outcome. The present study was designed to define whether post-operative release of interleukin (IL)-6, 8 and tumor necrosis factor-alpha (TNF-alpha) is related to the presence of a certain allele in functional polymorphis...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.02.007

    authors： Wang Z,Shao J,Zhou Q,Liu J,Zhu Y,Yang J,Wei M

    更新日期：2010-06-01 00:00:00

  • Human interleukin 4 is a glycosaminoglycan-binding protein.

    abstract：:Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0142

    authors： Lortat-Jacob H,Garrone P,Banchereau J,Grimaud JA

    更新日期：1997-02-01 00:00:00

  • Circulatory Omentin-1 levels but not genetic variants influence the pathophysiology of Type 2 diabetes.

    abstract：OBJECTIVE:Omentin-1, an anti-inflammatory protein, is secreted by the visceral adipose tissue. Altered levels of Omentin-1 are associated with obesity and Type 2 Diabetes (T2D). Although Omentin-1 is implicated in the insulin signaling pathway, the relationship between the genetic variants of Omentin-1 and T2D is not y...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.03.011

    authors： Rathwa N,Patel R,Pramanik Palit S,Jadeja SD,Narwaria M,Ramachandran AV,Begum R

    更新日期：2019-07-01 00:00:00

  • IL-10 induces gene expression in macrophages: partial overlap with IL-5 but not with IL-4 induced genes.

    abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00270-9

    authors： Stumpo R,Kauer M,Martin S,Kolb H

    更新日期：2003-10-01 00:00:00

  • Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity.

    abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.07.023

    authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

    更新日期：2006-08-01 00:00:00

  • Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

    abstract：:Tumour necrosis factor (TNF) is a major mediator in septic shock and several inflammatory diseases such as hepatitis. Galactosamine (GalN) sensitises experimental animals for TNF and the combination TNF/GalN leads to a lethal inflammatory hepatitis. We describe that a single injection of lipopolysaccharide (LPS), inte...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0912

    authors： Wielockx B,Hochepied T,Staelens J,Van Molle W,Brouckaert P,Libert C

    更新日期：2001-07-21 00:00:00

  • D-dopachrome tautomerase promotes IL-6 expression and inhibits adipogenesis in preadipocytes.

    abstract：:We previously identified D-dopachrome tautomerase (DDT) as a novel adipokine whose mRNA levels in adipocytes are negatively correlated with obesity-related clinical parameters, and which acts on adipocytes to regulate lipid metabolism. Here we investigated functions of DDT on preadipocytes. Recombinant DDT (rDDT) enha...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.07.037

    authors： Ishimoto K,Iwata T,Taniguchi H,Mizusawa N,Tanaka E,Yoshimoto K

    更新日期：2012-12-01 00:00:00

  • High level expression, activation, and antagonism of CC chemokine receptors CCR2 and CCR3 in Chinese hamster ovary cells.

    abstract：:The specificity of leukocyte trafficking in inflammation is controlled by the interactions of chemokines with chemokine receptors. Reliable structure-function studies of chemokine-receptor interactions would benefit from cell lines that express consistent high levels of chemokine receptors. We describe herein two new ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.03.013

    authors： Parody TR,Stone MJ

    更新日期：2004-07-07 00:00:00

  • IL-10 production in mouse hepatocytes augmented by TGF-beta.

    abstract：:The supernatant from normal liver cell (Clone 1469) culture enhanced polyclonal antibody production in mouse spleen cells but not in human peripheral blood lymphocytes. The supernatants from transforming growth factor beta (TGF-beta)-treated C3H/HeN spleen cells augmented greatly polyclonal antibody responses compared...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0112

    authors： Ishizaka S,Saito S,Yoshikawa M,Kimoto M,Nishiyama T

    更新日期：1996-11-01 00:00:00

  • Autocrine IL-6 regulates GRO-alpha production in thymic epithelial cells.

    abstract：:Thymic interleukin-6 (IL-6), which is produced primarily by thymic epithelial cells, is an important cytokine for T cell growth and differentiation in the thymus. In the present study, we investigated the effects of autocrine IL-6 on the cytokines in primary cultures of human thymic epithelial cells. Using an antibody...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.05.002

    authors： Tseng YL,Wu MH,Yang HC,Wang CY,Lin CF

    更新日期：2010-08-01 00:00:00

  • Chocolate consumption modulates cytokine production in healthy individuals.

    abstract：:Epidemiological studies suggest that chocolate increases the incidence and severity of acne. Here we demonstrate that chocolate consumption primes human blood mononuclear cells from volunteers to release more interleukin-1β (IL-1β) and IL-10 upon stimulation with Propionibacterium acne or Staphylcoccus aureus, the two...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2013.02.003

    authors： Netea SA,Janssen SA,Jaeger M,Jansen T,Jacobs L,Miller-Tomaszewska G,Plantinga TS,Netea MG,Joosten LA

    更新日期：2013-04-01 00:00:00

  • Multiple cytokine analysis in gastroschisis: Association with adverse outcomes including fetal brain damage.

    abstract：OBJECTIVES:To investigate the distribution of multiple cytokines in gastroschisis and reveal its association with clinical outcomes, including gastrointestinal disorders and fetal brain damage caused by chronic inflammation in gastroschisis. METHODS:We obtained amniotic fluid and arterial cord blood from 10 patients w...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2020.155406

    authors： Owaki T,Imai K,Miki R,Niwa Y,Kotani T,Nakano-Kobayashi T,Ushida T,Kajiyama H

    更新日期：2021-02-01 00:00:00

  • Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice.

    abstract：:Intestinal immunity differs from systemic immunity in several aspects and is frequently studied separately. In this work we have analysed the frequency of mononuclear cells spontaneously secreting the cytokines IL-2, IL-4, IL-5, IL-6, IL-10, interferon gamma (IFN-gamma) and tumour necrosis factor (TNF-alpha), in Peyer...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2000.0706

    authors： Vázquez E,Gil A,García-Olivares E,Rueda R

    更新日期：2000-08-01 00:00:00

  • Th1 and Th17 balance in inflammatory myopathies: interaction with dendritic cells and possible link with response to high-dose immunoglobulins.

    abstract：:To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistoc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.013

    authors： Tournadre A,Porcherot M,Chérin P,Marie I,Hachulla E,Miossec P

    更新日期：2009-06-01 00:00:00

  • Vascular endothelial growth factor: therapeutic possibilities and challenges for the treatment of ischemia.

    abstract：:Vascular endothelial growth factor (VEGF) is a notable chemokine that plays critical roles in angiogenesis and vasculogenesis. The contemporary body of literature contains a substantial amount of information regarding its chemical properties as well as its fundamental role in vascular development. Studies strongly ind...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2014.08.005

    authors： Crafts TD,Jensen AR,Blocher-Smith EC,Markel TA

    更新日期：2015-02-01 00:00:00

  • Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome.

    abstract：:The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15Ralpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed ...

    journal_title：Cytokine

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cyto.2008.04.008

    authors： Pistilli EE,Devaney JM,Gordish-Dressman H,Bradbury MK,Seip RL,Thompson PD,Angelopoulos TJ,Clarkson PM,Moyna NM,Pescatello LS,Visich PS,Zoeller RF,Gordon PM,Hoffman EP

    更新日期：2008-07-01 00:00:00

  • Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis.

    abstract：:Colony stimulating factors (CSF) promote leukocyte survival by reducing apoptotic cell death. However, their effects on non-leukocyte cell types are unclear. Reduced apoptosis in colon epithelial cells is thought to contribute to the initiation of cancer. Here, we report diminished spontaneous apoptosis of human colon...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1999

    authors： Calatayud S,Warner TD,Breese EJ,Mitchell JA

    更新日期：2002-11-24 00:00:00

  • Lower epicardial adipose tissue adiponectin in patients with metabolic syndrome.

    abstract：BACKGROUND:Adiponectin is an anti-atherogenic insulin-sensitizer hormone whose plasma concentration is lower in patients with metabolic syndrome (MS). Visceral adiposity, including epicardial adipose tissue (EAT), is closely related to the development of MS and coronary artery disease (CAD). We sought to study whether ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.01.016

    authors： Teijeira-Fernandez E,Eiras S,Shamagian LG,Somoza AS,Delgado C,Gonzalez-Juanatey JR

    更新日期：2011-05-01 00:00:00

  • Interleukin 35 (IL-35) and IL-37: Intestinal and peripheral expression by T and B regulatory cells in patients with Inflammatory Bowel Disease.

    abstract：:The aim of the study was to characterize and to quantify peripheral and tissue. IL-35- and IL-37-producing cells in Inflammatory Bowel Disease (IBD) patients. We studied a total of 38 active UC, 31 inactive UC, 17 active CD, and 13 inactive CD and 50 non-inflamed tissues as control group. Gene expression was measured ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.04.009

    authors： Fonseca-Camarillo G,Furuzawa-Carballeda J,Yamamoto-Furusho JK

    更新日期：2015-10-01 00:00:00

  • Cytokine gene expression in splenic macrophages and Kupffer cells following haemorrhage.

    abstract：:TNF-alpha, IL-1, IL-6 and TGF-beta are important macrophage-derived mediators which play the pleiotropic role in inflammatory, metabolic, hematopoietic and immunologic processes. Studies have shown that haemorrhagic shock without significant tissue trauma induces profound immunosuppression which is associated with ele...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.1002

    authors： Zhu XL,Zellweger R,Zhu XH,Ayala A,Chaudry IH

    更新日期：1995-01-01 00:00:00

  • Multiple cytokine secretion by IL-7-stimulated human T cells.

    abstract：:The induction of cytokine secretion by human peripheral blood (PB) T cells was examined. Highly purified T cells stimulated with interleukin 7 (IL-7), in the absence of co-mitogen, secreted IL-2, IL-4, IL-6 and interferon gamma (IFN-gamma) upon restimulation with phorbol ester and ionomycin. In contrast, induction of ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(92)90006-d

    authors： Armitage RJ,Macduff BM,Ziegler SF,Grabstein KH

    更新日期：1992-11-01 00:00:00

  • Influence of recombinant human erythropoietin on neutrophil function in premature neonates.

    abstract：:The in vivo influence of recombinant human erythropoietin (rhEpo) and iron on human neutrophil (PMN) antimicrobial function was assessed. A total of 21 preterm infants were randomized to receive either 200 U/kg/other day of rHuEPO+12 mg/kg/day of iron (EPO+high Fe, seven infants) or 200 U/kg/other day of rhEPO+4 mg/kg...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1006/cyto.1998.0393

    authors： Soubasi V,Roilides E,Tsantali C,Mussafiris K,Tsakiris D,Kremenopoulos G

    更新日期：1999-01-01 00:00:00

  • Gut immune stimulation by non pathogenic Gram(+) and Gram(-) bacteria. Comparison with a probiotic strain.

    abstract：:We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.11.014

    authors： Dogi CA,Galdeano CM,Perdigón G

    更新日期：2008-03-01 00:00:00

  • Serum VEGF levels and tissue activation of VEGFR2/KDR receptors in patients with breast and gynecologic cancer.

    abstract：OBJECTIVES:Vascular endothelial cell growth factor (VEGF) plays an important role in the biology of gynecological cancer, usually linked with aggressive tumour behaviour and a poor postoperative outcome. Yet, its role in benign breast/gynecological conditions is less clear. METHODS:Serum VEGF was analysed in a series ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.12.007

    authors： Koukourakis MI,Limberis V,Tentes I,Kontomanolis E,Kortsaris A,Sivridis E,Giatromanolaki A

    更新日期：2011-03-01 00:00:00

  • Tumor necrosis factor α induces a model of preeclampsia in pregnant baboons (Papio hamadryas).

    abstract：:Preeclampsia is a common disease of pregnancy characterised by maternal hypertension and proteinuria. Abnormal placentation in early pregnancy and abnormal cytokine and anti-angiogenic factor expression are thought to contribute to the clinical syndrome of endothelial dysfunction evident in the second half of gestatio...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.06.003

    authors： Sunderland NS,Thomson SE,Heffernan SJ,Lim S,Thompson J,Ogle R,McKenzie P,Kirwan PJ,Makris A,Hennessy A

    更新日期：2011-11-01 00:00:00

  • Interleukin 1beta as stimulator of the rat thymus.

    abstract：:The effects of interleukin 1beta administration on the thymus of adult and old rats were studied in order to study the interactions between the nervous and immune systems and to confirm the important role played by catecholaminergic nerve fibres (CNF) in the regulation of thymic functions. Moreover, chemical sympathec...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0924

    authors： Artico M,Cavallotti C,Cameroni M,Cavallotti D

    更新日期：2001-09-07 00:00:00

  • Comparison of the functional properties of murine dendritic cells generated in vivo with Flt3 ligand, GM-CSF and Flt3 ligand plus GM-SCF.

    abstract：:Flt3 ligand (FL) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are important growth factors for dendritic cells (DC). Substantial numbers of DC can be generated in vivo following the administration of either factor. We sought to extend our knowledge of the functional properties of these cells including...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0995

    authors： Daro E,Butz E,Smith J,Teepe M,Maliszewski CR,McKenna HJ

    更新日期：2002-02-07 00:00:00

  • Cytokine-mediated FOXO3a phosphorylation suppresses FasL expression in hemopoietic cell lines: investigations of the role of Fas in apoptosis due to cytokine starvation.

    abstract：:We have investigated phosphatidylinositol 3-kinase (PI3K)-dependent survival signalling pathways using several cytokines in three different hemopoietic cell lines, MC/9, FDC-P1, and TF-1. Cytokines caused PI3K- and PKB-dependent phosphorylation of FOXO3a (previously known as FKHRL1) at three distinct sites. Following ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.05.004

    authors： Behzad H,Jamil S,Denny TA,Duronio V

    更新日期：2007-05-01 00:00:00

  • Sexual dimorphism, weight gain and glucose intolerance in a B- and T-cell deficient mouse model.

    abstract：BACKGROUND:Estrogen is thought to aid maintenance of insulin sensitivity potentially through modulation of a counter-regulatory mechanism that interferes with the contribution of adaptive and innate immune systems to visceral fat deposition. We evaluated the impact of estrogen on long-term high fat diet (HFD) intake in...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.02.011

    authors： Wintrob ZA,Oppong EK,Foster M,Martorana M,Tse YC,Zhong L,Welt JM,Boateng HR,Drumea IM,Irlam J,Levea CM,Faitar SL,Ceacareanu AC

    更新日期：2014-06-01 00:00:00