Abstract:
:The effects of interleukin 1beta administration on the thymus of adult and old rats were studied in order to study the interactions between the nervous and immune systems and to confirm the important role played by catecholaminergic nerve fibres (CNF) in the regulation of thymic functions. Moreover, chemical sympathectomy was performed in a group of rats to study the effects on thymus of the destruction of the majority of CNF. Our results indicate that thymic stimulation (performed by means of interleukin 1beta) induces substantial changes in the fresh weight of the whole thymus, as well as in the thymic microenvironment, thymic nerve fibres, CNF, neuropeptide Y (NPY)-like positive nerve fibres and total amount of both proteins and norepinephrine in rat thymic tissue homogenates. The majority of CNF are destroyed after chemical sympathectomy with 6-OH-Dopamine (DA) and remain unchanged after treatment with interleukin 1beta.
journal_name
Cytokinejournal_title
Cytokineauthors
Artico M,Cavallotti C,Cameroni M,Cavallotti Ddoi
10.1006/cyto.2001.0924keywords:
subject
Has Abstractpub_date
2001-09-07 00:00:00pages
261-5issue
5eissn
1043-4666issn
1096-0023pii
S1043-4666(01)90924-Xjournal_volume
15pub_type
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