Abstract:
:Nasopharyngeal carcinoma (NPC) is a fast-growing cancer characterized by high occurrences of nodal and distant metastases and poor prognosis. It is therefore important to identify new serum biomarkers for the early diagnosis and prognostic prediction of this disease. The present study identifies biomarkers in NPC patient serum using a solid-phase antibody array detecting the expression profiles of 174 cytokines in a single experiment. ELISA was performed to validate the array results. The levels of TIMP-2, SELL, CCL24, MMP-1, MMP-3, IGF-I and IL-8 were significantly higher in serum from NPC patients, while the levels of MSP-alpha and HCC-4 were lower. Furthermore, the validation results were identical to those obtained from the antibody array. These results indicate that these cytokines might serve as novel biomarkers for the diagnosis and prognostic prediction of NPC.
journal_name
Cytokinejournal_title
Cytokineauthors
Gong D,Li Z,Ding R,Cheng M,Huang H,Liu A,Kang M,He H,Xu Y,Shao J,Wang Y,Duan Cdoi
10.1016/j.cyto.2018.04.031subject
Has Abstractpub_date
2019-06-01 00:00:00pages
107-114eissn
1043-4666issn
1096-0023pii
S1043-4666(18)30184-4journal_volume
118pub_type
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