Redox modulation of NO-dependent induction of interleukin 8 gene in monocytic U937 cells.

abstract：:The purpose of this study is to evaluate local levels of interleukin-1 beta (IL-1 beta), -4 (IL-4), -6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha), in a model of murine osteomyelitis due to Staphylococcus aureus. Cytokine levels in supernatants derived from bone homogenates were determined by enzyme-linked im...

journal_title：Cytokine

authors： Yoshii T,Magara S,Miyai D,Nishimura H,Kuroki E,Furudoi S,Komori T,Ohbayashi C

更新日期：2002-07-21 00:00:00

abstract：:Fetal liver is the main site of haematopoiesis during mid-gestation. The adult liver still provides a favourable environment for extramedullary haematopoiesis. Nevertheless, regulation of liver haematopoiesis by cell-cell contacts or by cytokines remains poorly understood. Recently, we have shown that rat liver epithe...

journal_title：Cytokine

authors： Rialland M,Corlu A,Ilyin G,Cabillic F,Lamy I,Guguen-Guillouzo C

更新日期：2000-07-01 00:00:00

abstract：:Angiopoietin-like proteins (ANGPTL) are responsible for inhibiting lipoprotein lipase activity, and ANGPTL3 and ANGPTL4 deficiencies have been shown to lower lipoprotein levels in animal models and in humans carrying loss-of-function mutations. Sickle cell anemia (SCA) is a hereditary hemolytic anemia characterized by...

journal_title：Cytokine

authors： Vendrame F,Olops L,Saad STO,Costa FF,Fertrin KY

更新日期：2019-08-01 00:00:00

abstract：:Intestinal epithelial cells can be induced to secrete the chemokine interleukin (IL)-8 during inflammation. The PAR-2 receptor is believed to play a proinflammatory role and is expressed in gut epithelial cells. The aim was to investigate PAR-2 signaling in Caco-2 intestinal epithelial cells, with respect to chemokine...

journal_title：Cytokine

authors： Fyfe M,Bergström M,Aspengren S,Peterson A

更新日期：2005-09-07 00:00:00

abstract：:Neovastat® is a standardized extract of marine cartilage, an avascular tissue, which contains many biologically active molecules and has multiple antiangiogenic properties. In addition to VEGFR2 and MMPs inhibition, shark cartilage extract (SCE) has recently been shown to induce tissue plasminogen activator gene (PLAT...

journal_title：Cytokine

authors： Simard B,Ratel D,Dupré I,Pautre V,Berger F

更新日期：2013-01-01 00:00:00

abstract：:Typically, ovarian cancer remains restricted to the peritoneal cavity. Because of this unique localization, the study of ovarian cancer is particularly suitable for immune analysis and for the development of immunotherapy. Here we report that peritoneal fluid from patients with ovarian or other intra-abdominal cancers...

journal_title：Cytokine

authors： Gotlieb WH,Abrams JS,Watson JM,Velu TJ,Berek JS,Martínez-Maza O

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The effectual immune response is crucial to defeat viral infections. However, exuberant immune response with features of macrophage activation syndrome (MAS) lead detrimental consequences in COVID-19 patients. Interleukin (IL)-18 is one of the leading cytokines in MAS which has not been studied in COVID-19. ...

journal_title：Cytokine

authors： Satış H,Özger HS,Aysert Yıldız P,Hızel K,Gulbahar Ö,Erbaş G,Aygencel G,Guzel Tunccan O,Öztürk MA,Dizbay M,Tufan A

更新日期：2021-01-01 00:00:00

abstract：:Using different binding assays we examined the interaction of the cytokine interleukin 4 (IL-4) with basement membrane. Equilibrium binding analysis revealed a high-affinity site characterized by a dissociation constant (Kd) of 0.3 nM. This interaction was confirmed by native polyacrylamide gel electrophoresis, which ...

journal_title：Cytokine

authors： Lortat-Jacob H,Garrone P,Banchereau J,Grimaud JA

更新日期：1997-02-01 00:00:00

abstract：:The hypothesis that IL-10, in addition to down-regulating pro-inflammatory activities of macrophages, induces an alternative state of macrophage reactivity was tested. We therefore conducted a systematic search for genes induced by IL-10 using the method of suppression subtractive hybridisation. Of an initial 1,300 ca...

journal_title：Cytokine

authors： Stumpo R,Kauer M,Martin S,Kolb H

更新日期：2003-10-01 00:00:00

abstract：:In this study we have examined the effect of agents known to perturb certain signal transduction pathways on the biological responses of target cells to stimulation with interleukin-1 (IL-1). In the murine thymoma cell line EL4, IL-1 stimulation results in the secretion of interleukin-2 (IL-2), which was subsequently ...

journal_title：Cytokine

authors： Rollins P,Witham S,Ray K,Thompson N,Sadler H,Smithers N,Grenfell S,Solari R

更新日期：1991-01-01 00:00:00

abstract：:Peptic ulcer is a lesion in the mucosa of the digestive tract affecting many people all around the world. Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. ...

journal_title：Cytokine

authors： Tourani M,Habibzadeh M,Karkhah A,Shokri-Shirvani J,Barari L,Nouri HR

更新日期：2018-10-01 00:00:00

abstract：:Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss i...

journal_title：Cytokine

authors： Su EW,Lin JY,Kane LP

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...

journal_title：Cytokine

authors： Savarraj JP,McGuire MF,Parsha K,Hergenroeder G,Bajgur S,Ahn S,Zhu L,Espino E,Chang T,Blackburn S,Kim DH,Dash P,Choi HA

更新日期：2018-11-01 00:00:00

abstract：:Interleukin 1alpha (IL-1alpha), a pleiotropic cytokine with multiple anti-tumour activities, has been investigated in our laboratory for its potential to serve as an immunotherapeutic agent. In the present study, an attempt was made to direct IL-1alpha to macrophages, in order to induce their immunoregulatory activiti...

journal_title：Cytokine

authors： Mullerad J,Cohen S,Voronov E,Apte RN

更新日期：2000-11-01 00:00:00

abstract：:There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CH...

journal_title：Cytokine

authors： Santos TPS,Pereira MM,Schinoni MI,Sampaio GP,Aras R Jr,Atta MLS,Atta AM

更新日期：2019-03-01 00:00:00

abstract：:Gangliosides have been extensively described to be involved in the proliferation and differentiation of various cell types, such including hematopoietic cells. Our previous studies on murine models of stroma-mediated myelopoiesis have shown that gangliosides are required for optimal capacity of stromal cells to suppor...

journal_title：Cytokine

authors： Santos AX,Maia JE,Crespo PM,Pettenuzzo LF,Daniotti JL,Barbé-Tuana FM,Martins LM,Trindade VM,Borojevic R,Guma FC

更新日期：2011-12-01 00:00:00

abstract：:We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associ...

journal_title：Cytokine

authors： Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney AL

更新日期：1999-10-01 00:00:00

abstract：:The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15Ralpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed ...

journal_title：Cytokine

authors： Pistilli EE,Devaney JM,Gordish-Dressman H,Bradbury MK,Seip RL,Thompson PD,Angelopoulos TJ,Clarkson PM,Moyna NM,Pescatello LS,Visich PS,Zoeller RF,Gordon PM,Hoffman EP

更新日期：2008-07-01 00:00:00

abstract：:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...

journal_title：Cytokine

authors： Oishi K,Mimura-Kimura Y,Miyasho T,Aoe K,Ogata Y,Katayama H,Murata Y,Ueoka H,Matsumoto T,Mimura Y

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:Long-term exposure to biomass-burning smoke (BS) is associated with chronic obstructive pulmonary disease (COPD), asthma, and other chronic inflammatory lung diseases. BS results from such processes as the burning of wood for indoor cooking and heating, with women and children having the highest exposure rate. This st...

journal_title：Cytokine

authors： Falfán-Valencia R,Ramírez-Venegas A,Pérez Lara-Albisua JL,Ramírez-Rodriguez SL,Márquez-García JE,Buendía-Roldan I,Gayosso-Gómez LV,Pérez-Padilla R,Ortiz-Quintero B

更新日期：2020-07-01 00:00:00

abstract：:The hypothalamic-pituitary-adrenal (HPA) axis is stimulated during immune and inflammatory processes. Interleukin 1beta (IL-1beta) and lipopolysaccharide (LPS) are known to be potent stimulators of this axis. During postnatal development, the rat seems to be hyporesponsive to many stimuli. The effects of repeated syst...

journal_title：Cytokine

authors： Bumiller A,Götz F,Rohde W,Dörner G

更新日期：1999-03-01 00:00:00

abstract：:Interleukin 12 (IL-12) is a heterodimer comprising p35 and p40 subunits which are encoded and regulated separately. The authors previously demonstrated deficient IL-12 production in SLE which correlates negatively with disease activity. The present study was designed to determine whether deficiency of IL-12 and excess...

journal_title：Cytokine

authors： Liu TF,Jones BM,Wong RW,Srivastava G

更新日期：1999-10-01 00:00:00

abstract：:Acute respiratory distress syndrome following an acute lung injury (ALI) is a life threatening inflammatory condition predominantly characterized by vascular protein leakage, neutrophil recruitment and overexpression of proinflammatory cytokines. Pulmonary and systemic bacterial infections are the major cause of ALI w...

journal_title：Cytokine

authors： Trivedi J,Shaikh J,Chavan N,Thorve D,Chaudhary B,Karade A,Gupta S,Patel A,Bhagwat S

更新日期：2020-05-01 00:00:00

abstract：:Candida albicans is an opportunistic fungal pathogen that colonizes human gastro-intestinal mucosal tissues. Its effect on the immune response in intestinal epithelial cells and on the intestinal mucosal barrier are not yet fully understood. In this study, we investigated Caco-2 cells, a monolayer model of intestinal ...

journal_title：Cytokine

authors： Mao X,Qiu X,Jiao C,Lu M,Zhao X,Li X,Li J,Ma J,Zhang H

更新日期：2020-02-01 00:00:00

abstract：:Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...

journal_title：Cytokine

authors： Maheshwari A,Voitenok NN,Akalovich S,Shaik SS,Randolph DA,Sims B,Patel RP,Killingsworth CR,Fallon MB,Ohls RK

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels o...

journal_title：Cytokine

authors： Brys A,Stasio ED,Lenaert B,Picca A,Calvani R,Marzetti E,Gambaro G,Bossola M

更新日期：2020-11-01 00:00:00

abstract：:We investigated the effects of either intravenous (IV) or intrabronchial (IB) treatment with transforming growth factor beta1 (TGF-beta1) during bacterial pneumonia in rats. Immediately following IB Escherichia coli inoculation (T0), animals (n=270) were randomized to receive a single treatment with human recombinant ...

journal_title：Cytokine

authors： Cui X,Zeni F,Vodovitz Y,Correa-de-Araujo R,Quezado M,Roberts A,Wahl S,Danner RL,Banks SM,Gerstenberger E,Fitz Y,Natanson C,Eichacker PQ

更新日期：2003-11-21 00:00:00

abstract：:Identifying and blocking chemokine inflammatory mediators in pediatric opsoclonus-myoclonus syndrome (OMS) is critical to the treatment of this autoimmune, paraneoplastic, neurological disorder. In a prospective, case-control, clinico-scientific study of children with OMS compared to non-inflammatory neurological cont...

journal_title：Cytokine

authors： Pranzatelli MR,Tate ED,McGee NR,Ransohoff RM

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Two assays--isolated peripheral blood mononuclear cells (PBMC) and a whole blood assay (WBA)--are commonly used to study TNF-alpha production by an individual in order to distinguish between high and low cytokine producers. We assessed the reliability and reproducibility of these assays. METHODS:The PBMC as...

journal_title：Cytokine

authors： Bakiyeva LT,Brooks RA,Rushton N

更新日期：2005-04-07 00:00:00