Abstract:
:We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.
journal_name
Cytokinejournal_title
Cytokineauthors
Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney ALdoi
10.1006/cyto.1999.0485keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
729-35issue
10eissn
1043-4666issn
1096-0023pii
S1043-4666(99)90485-4journal_volume
11pub_type
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