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Neutrophil microparticles modulate cytokine production by natural killer cells.

Abstract：

:Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α but enhanced the release of TGF-β1 by IL-2/IL-12-activated NK cells. The inhibitory effect of NMs was strongly attenuated by blockade of phosphatidylserine exposed on NMs. Thus, NMs skew the cytokine profile of NK cells from pro-inflammatory toward anti-inflammatory, potentially favoring the resolution of inflammation.

journal_name

Cytokine

journal_title

Cytokine

authors

Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

doi

10.1016/j.cyto.2013.11.010

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

126-9

issue

2

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(13)00760-6

journal_volume

65

pub_type

杂志文章

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