当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > Level of tear cytokines in population-level participants and correlation with clinical features.

Level of tear cytokines in population-level participants and correlation with clinical features.

Abstract：

AIMS:Tear cytokine levels indicate severity of ocular surface inflammation. Previous reports of cytokine concentrations were based on hospital-based studies or non-Chinese populations. We determine the range of tear concentration of cytokines in a representative adult Chinese population. METHODS:Thirty-nine participants were recruited from a population-based study of Chinese adults in Singapore, and standardized clinical ocular surface/eyelid features evaluated. Tear was extracted from Schirmer strips and analysed using a multiplex bead-based assay. RESULTS:Tear concentrations of 14 cytokines were investigated and quantifiable in each participant. Eight cytokines increased with increasing age, and 4 cytokines (IL-4, IL-12, IL-10 and IFN-γ) were increased in people with increased frequency of ocular discomfort. Three cytokines (MCP-1, IP-10 and IL-13) had increased levels in people with lower Schirmer tests, while 9 other cytokines were increased in patients with eyelid crusting (TNF-α, IL-1β, IL-17α, IL-2, IL-4, IL-6, IL-12, IL-10 and IFN-γ). Twelve percent of participants had eyelid crusting. CONCLUSION:Using a convenient collection technique that is a routine clinical test, 14 tear cytokines could be quantifiable even in Singapore Chinese adults without a dry eye diagnosis. Elevation of different tear cytokines may be linked to subclinical aqueous tear deficiency or eyelid inflammation even in asymptomatic people.

journal_name

Cytokine

journal_title

Cytokine

authors

Tong L,Wong TY,Cheng Y

doi

10.1016/j.cyto.2018.05.013

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

452-458

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(18)30214-X

journal_volume

110

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • IL-10 overexpression differentially affects cartilage matrix gene expression in response to TNF-alpha in human articular chondrocytes in vitro.

    abstract：:Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2008.10.012

    authors： Müller RD,John T,Kohl B,Oberholzer A,Gust T,Hostmann A,Hellmuth M,Laface D,Hutchins B,Laube G,Veh RW,Tschoeke SK,Ertel W,Schulze-Tanzil G

    更新日期：2008-12-01 00:00:00

  • FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.

    abstract：:We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1999.0485

    authors： Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney AL

    更新日期：1999-10-01 00:00:00

  • Regulation of the interleukin-1 receptor antagonist in THP-1 cells by ligands of the peroxisome proliferator-activated receptor gamma.

    abstract：:Monocytes/macrophages (Mphi) play a pivotal role in the persistence of chronic inflammation and local tissue destruction in diseases such as rheumatoid arthritis and atherosclerosis. The production by Mphi of cytokines, chemokines, metalloproteinases and their inhibitors is an essential component in this process, whic...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.1945

    authors： Meier CA,Chicheportiche R,Juge-Aubry CE,Dreyer MG,Dayer JM

    更新日期：2002-06-21 00:00:00

  • The critical role of macrophage migration inhibitory factor in insulin activity.

    abstract：:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knoc...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.05.013

    authors： Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

    更新日期：2014-09-01 00:00:00

  • Effect of psoriasis activity on VEGF and its soluble receptors concentrations in serum and plaque scales.

    abstract：:Vascular endothelial growth factor (VEGF) demonstrating pro-angiogenic activity promote new blood vessel formation in psoriatic lesions. The aim of this study was to evaluate the serum concentrations of VEGF, its soluble receptors (sVEGF R1 and R2) and VEGF content in scales of patients with psoriasis. To analyze poss...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.09.012

    authors： Flisiak I,Zaniewski P,Rogalska M,Myśliwiec H,Jaroszewicz J,Chodynicka B

    更新日期：2010-12-01 00:00:00

  • Cytokine profile of macrophage activation syndrome associated with Kawasaki disease.

    abstract：:The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sT...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.03.001

    authors： Jinkawa A,Shimizu M,Nishida K,Kaneko S,Usami M,Sakumura N,Irabu H,Takakuwa M,Inoue N,Mizuta M,Ikawa Y,Fujita S,Yachie A

    更新日期：2019-07-01 00:00:00

  • Strategies targeting the IL-4/IL-13 axes in disease.

    abstract：:IL-4 and IL-13 are pleiotropic Th2 cytokines produced by a wide variety of different cell types and responsible for a broad range of biology and functions. Physiologically, Th2 cytokines are known to mediate host defense against parasites but they can also trigger disease if their activities are dysregulated. In this ...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2015.05.018

    authors： May RD,Fung M

    更新日期：2015-09-01 00:00:00

  • Systemic blood osteopontin, endostatin, and E-selectin concentrations after vertical banding surgery in severely obese adults.

    abstract：BACKGROUND:Obesity is associated with endothelial dysfunction and increased inflammation as well as with expansion of the capillary bed in regional adipose deposits, and a balance between these factors is involved in angiogenesis. Osteopontin (OPN) is a proinflammatory cytokine involved in regulating immune processes a...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.03.020

    authors： Komorowski J,Jankiewicz-Wika J,Kolomecki K,Cywinski J,Piestrzeniewicz K,Swiętoslawski J,Stepien H

    更新日期：2011-07-01 00:00:00

  • TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.

    abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0233

    authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

    更新日期：1997-10-01 00:00:00

  • Wheat gliadin promotes the interleukin-4-induced IgE production by normal human peripheral mononuclear cells through a redox-dependent mechanism.

    abstract：:Increased levels of serum IgE have been described in gliadin-intolerant patients; however, biological mechanisms implicated in this immunoglobulin production remained unknown. In this study, we demonstrated that in vitro crude gliadins and gliadin lysates (Glilys) promoted the IL-4-induced IgE production by human peri...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00100-5

    authors： Dugas B,Dugas N,Conti M,Calenda A,Pino P,Thomas Y,Mazier D,Vouldoukis I

    更新日期：2003-03-21 00:00:00

  • Synergistic effects of granulocyte-colony stimulating factor on bone marrow stromal cell transplantation for mice cerebral infarct.

    abstract：:This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2009.02.008

    authors： Hokari M,Kuroda S,Chiba Y,Maruichi K,Iwasaki Y

    更新日期：2009-05-01 00:00:00

  • Effect of age and hormonal state on cytokine synthesis in the monkey.

    abstract：:The authors studied plasma cytokine activity using cross reactive polyclonal antibodies to human cytokines in young and old female monkeys to determine if age had any effect on cytokine secretion, and compared hormonal effects as well. While interleukin 1 (IL-1) was not higher in aged cycling monkeys, it was after men...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0281

    authors： Kaack MB,Harrison RM,Roberts JA

    更新日期：1998-03-01 00:00:00

  • Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

    abstract：:Tumour necrosis factor (TNF) is a major mediator in septic shock and several inflammatory diseases such as hepatitis. Galactosamine (GalN) sensitises experimental animals for TNF and the combination TNF/GalN leads to a lethal inflammatory hepatitis. We describe that a single injection of lipopolysaccharide (LPS), inte...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0912

    authors： Wielockx B,Hochepied T,Staelens J,Van Molle W,Brouckaert P,Libert C

    更新日期：2001-07-21 00:00:00

  • Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity.

    abstract：BACKGROUND:Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a wide variety of autoantibodies, some of which are pathogenic. In recent years it has become more evident that the polyclonal B cell activation in SLE is T-cell dependent. The stimulation of the autoantibody producing B cells is li...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2006.07.023

    authors： Sabry A,Sheashaa H,El-Husseini A,Mahmoud K,Eldahshan KF,George SK,Abdel-Khalek E,El-Shafey EM,Abo-Zenah H

    更新日期：2006-08-01 00:00:00

  • Marked cell-type-specific differences in glycosylation of human interleukin-6.

    abstract：:Human interleukin-6 (IL-6) secreted by cytokine- or endotoxin-induced fibroblasts, monocytes, keratinocytes, endometrial stromal cells, and endothelial cells, when analyzed under denaturing and reducing conditions, consists of a set of differentially modified phosphoglycoproteins of molecular mass in the range from 23...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90018-9

    authors： May LT,Shaw JE,Khanna AK,Zabriskie JB,Sehgal PB

    更新日期：1991-05-01 00:00:00

  • Anti-nociceptive effect of IL-12p40 in a rat model of neuropathic pain.

    abstract：:IL-12p70 is a proinflammatory cytokine secreted by dendritic cells, monocytes and macrophages. It plays a crucial role in cell-mediated immunity by inducing proliferation of T cell and natural killer cells, and enhancing their cytotoxic activity. In adaptive immune response, it acts on naive T cells to differentiate i...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.03.021

    authors： Chen IF,Khan J,Noma N,Hadlaq E,Teich S,Benoliel R,Eliav E

    更新日期：2013-06-01 00:00:00

  • Differential effects of transforming growth factor beta2, dexamethasone and 1,25-dihydroxyvitamin D on human bone marrow stromal cells.

    abstract：:We have studied the effects of rhTGF-beta2, dexamethanosome (dex) and 1,25(OH)2D3 on human bone marrow stromal (HBMS) cells in long-term culture. A fraction on HBMS expressed type I collagen (Col I) and osteopontin, and transient treatment (48 h) with dex increased the number of alkaline phosphatase (ALP) positive cel...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0209

    authors： Fromigué O,Marie PJ,Lomri A

    更新日期：1997-08-01 00:00:00

  • Neutrophil microparticles modulate cytokine production by natural killer cells.

    abstract：:Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.11.010

    authors： Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

    更新日期：2014-02-01 00:00:00

  • Quantification of Interleukin-6 in cell culture medium using surface plasmon resonance biosensors.

    abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.04.004

    authors： Chou TH,Chuang CY,Wu CM

    更新日期：2010-07-01 00:00:00

  • Upregulation of TLR2 expression on G-CSF-mobilized peripheral blood stem cells is responsible for their rapid engraftment after allogeneic hematopoietic stem cell transplantation.

    abstract：:Granulocyte colony-stimulating factor (G-CSF) mobilized peripheral blood stem cells (PBSCs) are more frequently used as the cellular source in allogeneic hematopoietic stem cell transplantation (HSCT) than bone marrow stem cells (BMSCs) because they promote more rapid engraftment and immune reconstitution. However, th...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.12.020

    authors： Joo YD,Lee WS,Won HJ,Lee SM,Choi JH,Lee SM,Han KH,Park SG,Choi IW,Seo SK

    更新日期：2011-04-01 00:00:00

  • The rhGM-CSF-EPO hybrid protein MEN 11300 induces anti-EPO antibodies and severe anaemia in rhesus monkeys.

    abstract：:A recombinant human GM-CSF-EPO hybrid protein named MEN 11300 was administered biweekly for a total of 6 weeks to rhesus monkeys in order to evaluate its pharmacokinetic behaviour, tolerability and immunogenicity. In this primate species a strong antibody response was induced which neutralized the in vitro biological ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0384

    authors： Coscarella A,Liddi R,Di Loreto M,Bach S,Faiella A,van der Meide PH,Mele A,De Santis R

    更新日期：1998-12-01 00:00:00

  • Redox modulation of NO-dependent induction of interleukin 8 gene in monocytic U937 cells.

    abstract：:We have examined the effects of various antioxidants and inhibitors of redox-sensitive signal transduction pathways on induction of interleukin 8 (IL-8) gene by NO in monocytic U937 cells. We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00114-5

    authors： Turpaev K,Litvinov D,Justesen J

    更新日期：2003-07-01 00:00:00

  • An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17.

    abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.03.003

    authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

    更新日期：2014-07-01 00:00:00

  • Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF.

    abstract：:Neuropilin-1 (NRP-1) is a co-receptor for vascular endothelial growth factor (VEGF). During neovascularization, vascular smooth muscle cells (VSMCs) and pericytes modulate the function of endothelial cells. Factors that mediate NRP-1 in human VSMCs (hVSMCs) remain to be elucidated. We studied various angiogenic cytoki...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.09.009

    authors： Liu W,Parikh AA,Stoeltzing O,Fan F,McCarty MF,Wey J,Hicklin DJ,Ellis LM

    更新日期：2005-12-07 00:00:00

  • Effect of G(-174)C polymorphism in interleukin-6 gene on cardiovascular disease in type 2 diabetes patients.

    abstract：:Interleukin-6 (IL-6) is an important pro-inflammatory cytokine of relevance to cardiovascular diseases. The aim of this case-control study was to evaluate the association between the G(-174)C functional polymorphism in the IL-6 gene and risk of cardiovascular disease (CVD) in type 2 diabetes patients. We examined 1090...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.12.004

    authors： Buraczynska M,Zukowski P,Drop B,Baranowicz-Gaszczyk I,Ksiazek A

    更新日期：2016-03-01 00:00:00

  • IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract：:An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypert...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.02.008

    authors： Kim HY,Kim HS

    更新日期：2014-07-01 00:00:00

  • Nutritional effects on NF-kappaB/IkappaB activity in weight-gaining and -losing rats.

    abstract：BACKGROUND:We had previously reported metabolic abnormalities in TNF-treated weight-gaining (WG) rats, associated with increased soluble and membrane TNF receptors. OBJECTIVE:On the basis of these findings, we hypothesized that stabilization of TNF in circulation in WG animals by these receptors augmented the action o...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/s1043-4666(03)00105-4

    authors： Raina N,Jeejeebhoy KN

    更新日期：2003-06-21 00:00:00

  • Expression of monocyte chemotactic protein-3 in human monocytes exposed to the mycobacterial cell wall component lipoarabinomannan.

    abstract：:Monocyte chemotactic protein-3 (MCP-3) is a C-C chemokine which interacts with the CCR1, CCR2 (MCP-1) and CCR3 receptors and has a distinct spectrum of action. The present study was designed to assess whether mycobacterial components were able to induce expression and production of MCP-3 in human monocytes. Mycobacter...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0242

    authors： Vouret-Craviari V,Cenzuales S,Poli G,Mantovani A

    更新日期：1997-12-01 00:00:00

  • Epidermal growth factor, insulin-like growth factor-1 and basic fibroblast growth factor modulate the cytostatic effect of tumour necrosis factor-alpha on the breast cancer cell line, T47D.

    abstract：:The effect of epidermal growth factor (EGF), basic fibroblast growth factor (bFGF) and insulin-like growth factor-1 (IGF-1) on the cytostatic activity of tumour necrosis factor-alpha (TNF-alpha) was studied on the breast cancer cell line, T47D. TNF-alpha completely blocked the potent growth-promoting activity of all t...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(93)90056-b

    authors： Pusztai L,Lewis CE,McGee JO

    更新日期：1993-03-01 00:00:00

  • Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects.

    abstract：:Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patient...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2018.12.012

    authors： Sadeghabadi ZA,Ziamajidi N,Abbasalipourkabir R,Mohseni R,Borzouei S

    更新日期：2019-04-01 00:00:00