当前位置： SCI文献检索 > CYTOKINE期刊下所有文献 > The critical role of macrophage migration inhibitory factor in insulin activity.

The critical role of macrophage migration inhibitory factor in insulin activity.

Abstract：

:Macrophage migration inhibitory factor (MIF) is a molecule with plethora of functions such as regulation of immune response, hormone-like, enzymatic and chaperone-like activity. Further, MIF is a major participant in glucose homeostasis since it is an autocrine stimulator of insulin secretion. MIF absence in male knockout mice (MIF-KO) results in development of glucose intolerance, while sensitivity to insulin is fully preserved. Since our results confirm that beta cells from MIF-KO mice express, produce and secrete insulin similarly to beta cells of their wild type (WT) counterparts C57BL/6 mice, we hypothesize that MIF-KO-derived insulin is less active. Indeed, insulin from MIF-KO islets is unable to significantly induce glucose uptake into hepatocytes and to efficiently promote insulin-triggered Akt phosphorylation determined by immunoblot. However, MIF's tautomerase function is not crucial for insulin biosynthesis since MIF inhibitors had no impact on WT insulin activity. Importantly, MIF recognition by anti-MIF antibody (ELISA) after in vitro co-incubation with purified insulin was significantly lower suggesting that insulin covers MIF immunodominant epitope. In addition, MIF binds insulin within beta cell as confirmed by co-immunoprecipitation. WT and MIF-KO-derived insulin exhibited different cleavage patterns suggesting different protein conformations. Finally, pre-incubation of recombinant MIF with insulin promotes formation of insulin hexamers. These results imply that MIF probably enables proper insulin folding what results in insulin full activity. This newly discovered feature of the cytokine MIF could be potentially important for commercially produced insulin, for increasing its stability and/or bioavailability.

journal_name

Cytokine

journal_title

Cytokine

authors

Vujicic M,Senerovic L,Nikolic I,Saksida T,Stosic-Grujicic S,Stojanovic I

doi

10.1016/j.cyto.2014.05.013

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

39-46

issue

1

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(14)00146-X

journal_volume

69

pub_type

杂志文章

相关文献

CYTOKINE文献大全
  • In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.

    abstract：:Most infections occur in early life, prompting development of novel adjuvanted vaccines to protect newborns and infants. Several Toll-like receptor (TLR) agonists (TLRAs) are components of licensed vaccine formulations or are in development as candidate adjuvants. However, the type and magnitude of immune responses to...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.04.001

    authors： van Haren SD,Ganapathi L,Bergelson I,Dowling DJ,Banks M,Samuels RC,Reed SG,Marshall JD,Levy O

    更新日期：2016-07-01 00:00:00

  • Effects of hypothermia and re-warming on the inflammatory response in a murine multiple hit model of trauma.

    abstract：INTRODUCTION:Although, hypothermia is a frequent event after trauma, it is unclear whether its beneficial or detrimental effects are more important. This study aims to quantify the effects of hypothermia and re-warming on the inflammatory response after fracture/hemorrhage and subsequent fracture stabilization with res...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2005.06.008

    authors： Hildebrand F,van Griensven M,Giannoudis P,Luerig A,Harwood P,Harms O,Fehr M,Krettek C,Pape HC

    更新日期：2005-09-07 00:00:00

  • Use of a solid-phase random peptide library to identify inhibitors of TNF-alpha mediated cytotoxicity in vitro.

    abstract：:Tumour necrosis factor (TNF) is a pleiotropic cytokine which plays a central role in infection, inflammation and autoimmune diseases. Its functions are mediated through binding to high affinity cell surface receptors. An approach to modulate excessive levels of TNF-alpha in the serum is the use of soluble receptors. I...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1996.0158

    authors： Chirinos-Rojas CL,Steward MW,Partidos CD

    更新日期：1997-04-01 00:00:00

  • Plasma interleukin-1beta concentration is associated with stroke in sickle cell disease.

    abstract：:The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...

    journal_title：Cytokine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cyto.2009.10.002

    authors： Asare K,Gee BE,Stiles JK,Wilson NO,Driss A,Quarshie A,Adams RJ,Kutlar A,Hibbert JM

    更新日期：2010-01-01 00:00:00

  • Decreased CD4+CD8low T cells in early HIV infection are associated with rapid disease progression.

    abstract：BACKGROUND:HIV rapid progressors (RPs) present with a rapid decline of CD4+ T cells within a few years of infection. Determining the underlying mechanisms throughout this decline is important to identify prognostic biomarkers and intervention strategies. Determining the numbers of CD4+ and CD8+ T cells is essential for...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2019.154801

    authors： Ding ZD,Zheng JF,Song CB,Fu YJ,Xu JJ,Jiang YJ,Shang H,Zhang ZN

    更新日期：2020-01-01 00:00:00

  • Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis.

    abstract：:The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.05.014

    authors： Rechenberg DK,Bostanci N,Zehnder M,Belibasakis GN

    更新日期：2014-09-01 00:00:00

  • TNFalpha and IL-1beta exert no direct vasoactivity in human isolated resistance arteries.

    abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2002.2004

    authors： Pickkers P,Netea MG,van der Meer JW,Smits P

    更新日期：2002-12-07 00:00:00

  • Preferential production of IL-12 by peritoneal macrophages activated by liposomes prepared from neoglycolipids containing oligomannose residues.

    abstract：:The present study demonstrates that liposomes coated with synthesized neoglycolipids constructed from mannotriose and dipalmitoylphosphatidylethanolamine (Man3-DPPE) activate peritoneal macrophages (PEMs) to up-regulate expression of co-stimulatory molecules and preferentially secrete IL-12. Injection of Man3-DPPE-coa...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2007.10.005

    authors： Takagi H,Furuya N,Kojima N

    更新日期：2007-12-01 00:00:00

  • Regulation of the interleukin 2 receptor complex tyrosine kinase activity in vitro.

    abstract：:Interleukin 2 (IL-2) has been shown to stimulate tyrosine phosphorylation of a number of proteins requiring only the p75 beta chain of the IL-2 receptor. Unlike the receptors for epidermal growth factor, insulin, and other growth factors, the p55-alpha and p75-beta chains of the IL-2 receptor have no tyrosine protein ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(91)90047-h

    authors： Michiel DF,Garcia GG,Evans GA,Farrar WL

    更新日期：1991-09-01 00:00:00

  • LERK-7: a ligand of the Eph-related kinases is developmentally regulated in the brain.

    abstract：:The eph family is the largest subfamily of receptor tyrosine kinases (RTKs). Members of this subfamily display specific expression in the developing and adult brain. Recently, cDNAs encoding membrane bound ligands for these receptors have been identified which we have termed LERKs (ligand for eph-related kinases). We ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0199

    authors： Kozlosky CJ,VandenBos T,Park L,Cerretti DP,Carpenter MK

    更新日期：1997-08-01 00:00:00

  • An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17.

    abstract：BACKGROUND:Among all cytokines involved in the pathogenesis and in the progression of psoriasis, Tumor Necrosis Factor (TNF)-alpha and interleukin (IL)-17 play a pivotal role. OBJECTIVE:The aim of the present study was to mimic a psoriatic microenvironment and to investigate the early effects of TNF-alpha and IL-17 in...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.03.003

    authors： Donetti E,Cornaghi L,Gualerzi A,Baruffaldi Preis FW,Prignano F

    更新日期：2014-07-01 00:00:00

  • LPS-induced release of IL-1 beta, IL-6, IL-8, TNF-alpha and sCD14 in whole blood and PBMC from persons with high or low levels of HDL-lipoprotein.

    abstract：:We have examined basal and lipopolysaccharide (LPS)-induced release of interleukin 1 beta (IL-1 beta), interleukin 6 (IL-6), interleukin 8 (IL-8), tumour necrosis factor-alpha (TNF-alpha) and soluble CD14 (sCD14) in whole blood and peripheral blood mononuclear cells (PBMC) from 20 persons with either high (1.62-2.47 m...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/1043-4666(94)90080-9

    authors： Eggesbø JB,Hjermann I,Lund PK,Joø GB,Ovstebø R,Kierulf P

    更新日期：1994-09-01 00:00:00

  • Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production.

    abstract：:A well-known association between vitamin D(3) and infection with Mycobacterium tuberculosis has previously been reported, but little is known regarding the underlying mechanisms. We have investigated how 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] affects the proinflammatory cytokine production induced by M. tubercul...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2011.04.016

    authors： Khoo AL,Chai LY,Koenen HJ,Oosting M,Steinmeyer A,Zuegel U,Joosten I,Netea MG,van der Ven AJ

    更新日期：2011-08-01 00:00:00

  • Supplemental vitamin D increases serum cytokines in those with initially low 25-hydroxyvitamin D: a randomized, double blind, placebo-controlled study.

    abstract：:The purpose of this study was to determine if vitamin D status before supplementation influences the cytokine response after supplemental vitamin D. Forty-six reportedly healthy adults (mean(SD); age, 32(7) y; body mass index (BMI), 25.3(4.5) kg/m(2); serum 25-hydroxyvitamin D (25(OH)D), 34.8(12.2) ng/mL) were randoml...

    journal_title：Cytokine

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cyto.2014.09.012

    authors： Barker T,Rogers VE,Levy M,Templeton J,Goldfine H,Schneider ED,Dixon BM,Henriksen VT,Weaver LK

    更新日期：2015-02-01 00:00:00

  • The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells.

    abstract：:The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) regulates a battery of antioxidant, detoxification, and cell stress genes. It is activated by oxidative stress and a number of exogenous compounds, one of which is tert-butylhydroquinone (tBHQ), a widely used food preservative. Nrf2 modulates ...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2014.11.006

    authors： Turley AE,Zagorski JW,Rockwell CE

    更新日期：2015-02-01 00:00:00

  • Neutrophil microparticles modulate cytokine production by natural killer cells.

    abstract：:Neutrophil microparticles (NMs) are scarce in the circulation but are highly enriched at sites of inflammation and exert profound effects on immune cells. In the present study, we addressed whether NMs modulate cytokine-producing capacity of natural killer (NK) cells. NMs inhibited the production of IFN-γ and TNF-α bu...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2013.11.010

    authors： Pliyev BK,Kalintseva MV,Abdulaeva SV,Yarygin KN,Savchenko VG

    更新日期：2014-02-01 00:00:00

  • Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migration.

    abstract：:Vascular cell adhesion molecule-1 (VCAM-1) activates endothelial cell NADPH oxidase which catalyzes production of reactive oxygen species (ROS). This activity is required for VCAM-1-dependent lymphocyte migration. The focus of our study was to determine whether these VCAM-1-dependent functions are modulated by cytokin...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.2001.0922

    authors： Tudor KS,Hess KL,Cook-Mills JM

    更新日期：2001-08-21 00:00:00

  • Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts.

    abstract：:Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2015.01.016

    authors： Arad U,Madar-Balakirski N,Angel-Korman A,Amir S,Tzadok S,Segal O,Menachem A,Gold A,Elkayam O,Caspi D

    更新日期：2015-05-01 00:00:00

  • The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis.

    abstract：:The TNF-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily that has been recognized for its specific pro-apoptotic effect on cancer cells and has been therefore proposed as a treatment in cancer. Studies on animal models have shown that TRAIL could also have a benefici...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2013.04.011

    authors： Audo R,Combe B,Hahne M,Morel J

    更新日期：2013-08-01 00:00:00

  • TIMP-3 induces cell death by stabilizing TNF-alpha receptors on the surface of human colon carcinoma cells.

    abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) regulate the structural integrity of the extracellular matrix (ECM). Constitutive expression of human TIMP-3 in human DLD colon carcinoma cells renewed serum-responses and inhibited tumour formation in nude mice. To elucidate the mecha...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1997.0233

    authors： Smith MR,Kung H,Durum SK,Colburn NH,Sun Y

    更新日期：1997-10-01 00:00:00

  • TIM-1 and TIM-3 proteins in immune regulation.

    abstract：:Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss i...

    journal_title：Cytokine

    pub_type： 杂志文章,评审

    doi：10.1016/j.cyto.2008.06.013

    authors： Su EW,Lin JY,Kane LP

    更新日期：2008-10-01 00:00:00

  • Mouse genetic background influences severity of immune responses following trauma-hemorrhage.

    abstract：:Studies have shown that following bacterial infection or endotoxin administration, immune functions are regulated differently in mice of different genetic background. Since the susceptibility to sepsis following trauma-hemorrhage is dependant on the severity of injury, it is important to determine whether genetic back...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2004.12.019

    authors： Matsutani T,Anantha Samy TS,Kang SC,Bland KI,Chaudry IH

    更新日期：2005-05-21 00:00:00

  • Interleukin-10 promoter polymorphisms and asthma risk: a meta-analysis.

    abstract：:Several studies assessed the associations of interleukin-10 (IL-10) polymorphisms with asthma in different populations. However, the results were inconclusive. The aim of the present study was to further assess the associations by the method of meta-analysis. Pubmed, EMBASE, Wanfang Database, China National Knowledge ...

    journal_title：Cytokine

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.cyto.2012.08.023

    authors： Nie W,Fang Z,Li B,Xiu QY

    更新日期：2012-12-01 00:00:00

  • Quantification of Interleukin-6 in cell culture medium using surface plasmon resonance biosensors.

    abstract：:Interleukin (IL)-6, a multifunctional cytokine, is widely used as an index for illnesses such as inflammatory and autoimmune disorders, coronary artery disease, neurological disease, and gestational problems. It is thus very important to be able to precisely quantify the level of IL-6 for disease diagnosis and any sub...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.04.004

    authors： Chou TH,Chuang CY,Wu CM

    更新日期：2010-07-01 00:00:00

  • Association between cytokine removal by polymyxin B hemoperfusion and improved pulmonary oxygenation in patients with acute exacerbation of idiopathic pulmonary fibrosis.

    abstract：:Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is characterized by severe worsening dyspnea of unknown etiology and high mortality without effective treatment. Recently, direct hemoperfusion with polymyxin B (PMX)-immobilized fiber cartridge (PMX-DHP) has been reported to improve pulmonary oxygenation an...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2012.08.032

    authors： Oishi K,Mimura-Kimura Y,Miyasho T,Aoe K,Ogata Y,Katayama H,Murata Y,Ueoka H,Matsumoto T,Mimura Y

    更新日期：2013-01-01 00:00:00

  • Role of prostaglandins E1, E2 and F2 alpha in the brain in interleukin 1 beta-induced adrenocorticotropin secretion in the rat.

    abstract：:It is well known that interleukin (IL)-1 is a potent activator of the hypothalamo-pituitary-adrenal axis in the rat. Many studies have reported that prostaglandins (PGs), especially PGE2, in the brain may mediate the IL-1 stimulation of corticotropin-releasing hormone release, which then leads to adrenocorticotropin (...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1995.0083

    authors： Watanobe H,Sasaki S,Takebe K

    更新日期：1995-10-01 00:00:00

  • Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer.

    abstract：:Among New Mexican Hispanic women, breast cancer is detected at a more advanced stage than compared to Non-Hispanic White women. One central factor that has been little studied is the role of critical cytokines. We genotyped incident breast cancer cases and their age-, gender- and smoking-matched controls (N=40 matched...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1016/j.cyto.2010.03.014

    authors： Erdei E,Kang H,Meisner A,White K,Pickett G,Baca C,Royce M,Berwick M

    更新日期：2010-07-01 00:00:00

  • Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1.

    abstract：:Interleukin 1 (IL-1) activates p42/p44 and p38 mitogen-activated protein kinases (MAP kinases) in target cells. Here we have used two specific inhibitors, PD98059 which inhibits MAP kinase kinase (MEK), and SB203580 which inhibits p38 MAP kinase to explore the involvement of these kinases in the induction of IL-2 by I...

    journal_title：Cytokine

    pub_type： 杂志文章

    doi：10.1006/cyto.1998.0478

    authors： Matthews JS,O'Neill LA

    更新日期：1999-09-01 00:00:00

  • VEGF gene therapy cooperatively recruits molecules from the immune system and stimulates cell homing and angiogenesis in refractory angina.

    abstract：BACKGROUND:New vessels are formed in response to stimuli from angiogenic factors, a process in which paracrine signaling is fundamental. OBJECTIVE:To investigate the cooperative paracrine signaling profile in response to Vascular Endothelial Growth Factor (VEGF) gene therapy in patients with coronary artery disease (C...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.cyto.2016.12.005

    authors： Eibel B,Markoski MM,Rodrigues CG,Dipp T,de Salles FB,Giusti II,Nardi NB,Plentz RD,Kalil RA

    更新日期：2017-03-01 00:00:00

  • Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis.

    abstract：BACKGROUND:In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite de...

    journal_title：Cytokine

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.cyto.2016.11.016

    authors： Gadisa E,Tasew G,Abera A,Gelaye W,Chanyalew M,Abebe M,Laskay T,Aseffa A

    更新日期：2017-03-01 00:00:00