The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis.

abstract：:Although numerous studies have shown that visfatin is linked to several cancers, its prognostic value is still unclear. This first comprehensive meta-analysis was performed to evaluate the prognostic effect of visfatin in cancer patients. A systematic search was conducted for relevant studies in health-related electro...

journal_title：Cytokine

authors： Mohammadi M,Moradi A,Farhadi J,Akbari A,Pourmandi S,Mehrad-Majd H

更新日期：2020-03-01 00:00:00

abstract：:ALT-803 is a fusion protein complex consisting of an interleukin (IL)-15 superagonist and a dimeric IL-15 receptor alpha sushi domain IgG1 Fc fusion protein. When administered to mice, ALT-803 is capable of inducing natural killer (NK) and CD8+ T cell proliferation and activation, and effectively promoting potent anti...

journal_title：Cytokine

authors： Liu B,Jones M,Kong L,Noel T,Jeng EK,Shi S,England CG,Alter S,Miller JS,Cai W,Rhode PR,Wong HC

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...

journal_title：Cytokine

authors： Xie JJ,Wang J,Tang TT,Chen J,Gao XL,Yuan J,Zhou ZH,Liao MY,Yao R,Yu X,Wang D,Cheng Y,Liao YH,Cheng X

更新日期：2010-02-01 00:00:00

abstract：:Interferon (IFN) plays a central role in regulating host immune response to viral pathogens through the induction of IFN-Stimulated Genes (ISGs). IFN also enhances cellular SUMOylation and ISGylation, though the functional interplay between these modifications remains unclear. Here, we used a system-level approach to ...

journal_title：Cytokine

authors： El-Asmi F,McManus FP,Brantis-de-Carvalho CE,Valle-Casuso JC,Thibault P,Chelbi-Alix MK

更新日期：2020-05-01 00:00:00

abstract：:Thymic vulnerability, a leading cause of defective immunity, was discovered decades ago. To date, several strategies have been investigated to unveil any immunorestorative capacities they might confer. Studies exploiting castration, transplantation, adoptive cell therapies, hormones/growth factors, and cytokines have ...

journal_title：Cytokine

authors： El-Kadiry AE,Rafei M

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Unregulated inflammatory and thrombotic responses have been proposed to be important causes of early brain injury and worse clinical outcomes after subarachnoid hemorrhage (SAH). OBJECTIVE:We hypothesize that SAH is characterized by an increased inflammatory and thrombotic state and disruption of associatio...

journal_title：Cytokine

authors： Savarraj JP,McGuire MF,Parsha K,Hergenroeder G,Bajgur S,Ahn S,Zhu L,Espino E,Chang T,Blackburn S,Kim DH,Dash P,Choi HA

更新日期：2018-11-01 00:00:00

abstract：:We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associ...

journal_title：Cytokine

authors： Xie MH,Holcomb I,Deuel B,Dowd P,Huang A,Vagts A,Foster J,Liang J,Brush J,Gu Q,Hillan K,Goddard A,Gurney AL

更新日期：1999-10-01 00:00:00

abstract：:We had earlier shown that human foetal epithelial cells (WISH), growth-inhibited by interferon gamma (IFNgamma), were reversibly detained at a point prior to DNA synthesis. In the present study, we determined the window of action of IFNgamma in the G1 phase duration and the exact point of detention of WISH cells in ce...

journal_title：Cytokine

authors： Vashistha S,Patil S,Joshi C,Ajitkumar P

更新日期：2007-02-01 00:00:00

abstract：:Inflammatory bowel diseases are characterized by dysregulated immune response to the normal microflora and structural and functional changes of the enteric nervous system which occur in inflamed as well as non-inflamed areas of the bowel. This study describes the changes in the expression of nerve growth factor (NGF) ...

journal_title：Cytokine

authors： Barada KA,Mourad FH,Sawah SI,Khoury C,Safieh-Garabedian B,Nassar CF,Tawil A,Jurjus A,Saadé NE

更新日期：2007-03-01 00:00:00

abstract：:The objective of this study was to investigate the effects of the cytokines IFN-alpha, IL-6 and IL-10 present in the serum of systemic lupus erythematosus (SLE) patients on the differentiation and maturation of DCs derived from CD34(+) hematopoietic precursor cells (HPCs). CD34(+) HPCs cultured in SLE serum containing...

journal_title：Cytokine

authors： Zhang R,Xing M,Ji X,Gu L,Yang X,Wang H,Jiang P

更新日期：2010-05-01 00:00:00

abstract：:TLR2 is a toll-like receptor protein which is involved in innate immune responses. TLR2 recognize several virus, fungal and bacterial pathogens, upon their uptake cause internalization and cellular activation. During this process several cytokines participate including interleukins, IL6 and IL12. Interestingly, TLR2 i...

journal_title：Cytokine

authors： Undi RB,Sarvothaman S,Narasaiah K,Gutti U,Gutti RK

更新日期：2016-07-01 00:00:00

abstract：:Suspect field cases of BSE infection (displaying clinical signs) were examined for possible alterations of cytokine/autacoid plasma levels and were compared to control cases (not displaying clinical signs of BSE infection). Interferon gamma (IFN-gamma) plasma levels were demonstrated as being elevated in all suspected...

journal_title：Cytokine

authors： Murphy C,Breen C,Rogers M,Giese M

更新日期：2001-02-07 00:00:00

abstract：:Emerging evidence indicates that chemokine receptor expression patterns are critical in determining the spectrum of action of the chemokines. We have analysed the expression patterns of 17 chemokine receptors and two orphan chemokine receptor-like genes in various freshly prepared human peripheral blood leucocyte popu...

journal_title：Cytokine

authors： Patel L,Charlton SJ,Chambers JK,Macphee CH

更新日期：2001-04-07 00:00:00

abstract：:The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...

journal_title：Cytokine

authors： Sjöholm K,Lundgren M,Olsson M,Eriksson JW

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:We investigated the expression pattern and the role of inflammatory cytokines and their receptors in the placentas of pregnancy with HELLP syndrome. STUDY DESIGN:Placentas were collected after cesarean section, 10 from normal pregnancy and 10 from HELLP. The array was performed with GEArray Q Series Human In...

journal_title：Cytokine

authors： Tranquilli AL,Landi B,Corradetti A,Giannubilo SR,Sartini D,Pozzi V,Emanuelli M

更新日期：2007-11-01 00:00:00

abstract：:The evolution of malignant cells implies an increase in oncogenic fitness of cells which arises in active and reciprocal interaction with the tumor microenvironment. The mechanisms facilitating the adaptive evolution of cancer cells involve clonal selection of cancer cells, in a direction of increased adaptive potenti...

journal_title：Cytokine

authors： Todorović-Raković N

更新日期：2021-01-25 00:00:00

abstract：:IL-1 family members regulate innate immune responses, are produced by gestation-associated tissues, and have a role in healthy and adverse pregnancy outcomes. To better understand their role at the materno-fetal interface we used a human tissue explant model to map lipopolysaccharide (LPS)-stimulated production of IL-...

journal_title：Cytokine

authors： Scott LM,Bryant AH,Rees A,Down B,Jones RH,Thornton CA

更新日期：2017-11-01 00:00:00

abstract：:Intraarticular injection of zymosan (1 mg) into the knee joints of male Wistar rats led to infiltration of neutrophils and monocytes, joint swelling and elevation of tumour necrosis factor (TNF-alpha) in joint lavage fluids. Neutrophil infiltration was maximal at 5 h after induction of arthritis but had declined by 24...

journal_title：Cytokine

authors： Pettipher ER,Salter ED

更新日期：1996-02-01 00:00:00

abstract：:Human co-infection by helminth species is frequent, but their consequences are mostly unknown. Here, we investigate the impact of Strongyloides venezuelensis co-infection on the immune response, schistosome burden, and the associated pathology of schistosomiasis in mice. Co-infection did not alter the schistosome para...

journal_title：Cytokine

authors： de Rezende MC,Moreira JMP,Fernandes LLM,Rodrigues VF,Negrão-Corrêa D

更新日期：2020-03-01 00:00:00

abstract：:CoPoIFN-α is a recombinant non-naturally occurring porcine interferon-α (IFN-α). It was designed by scanning 17 porcine IFN-α nonallelic subtypes and assigning the most frequently occurring amino acid in each position. We used a porcine IFN-α (PoIFN-α) derived from domestic pig as a control. Both porcine IFN-α genes w...

journal_title：Cytokine

authors： Huang L,Cao RB,Wang N,Liu K,Wei JC,Isahg H,Song LJ,Zuo WY,Zhou B,Wang WW,Mao X,Chen PY

更新日期：2012-01-01 00:00:00

abstract：:Pro-inflammatory cytokines are important mediators in tissue responses to a wide range of endogenous (e.g. autoantigens) and exogenous (e.g. infections, wounds, biomaterials) stimuli. The complex interactions taking place between different cell types in such processes are difficult to examine in vivo. Here we studied ...

journal_title：Cytokine

authors： Gretzer C,Thomsen P,Jansson S,Nilsson M

更新日期：2000-01-01 00:00:00

abstract：:Three representative cytokines interleukin (IL-8), RANTES and tumour necrosis factor alpha (TNF-alpha) have a concentration-dependent chemotactic effect on the unicellular Tetrahymena. Maximal effective concentrations of IL-8 (1 ng/ml) and RANTES (75 ng/ml) are in the same range as in mammals, which indicates an evolu...

journal_title：Cytokine

authors： Köhidai L,Csaba G

更新日期：1998-07-01 00:00:00

abstract：:The gene polymorphisms interferon-gamma (IFN-gamma) +874 T/A and interleukin (IL)-4 -590 C/T have been associated with the altered production of cytokines. Therefore, they might be indicative of the occurrence of Paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. The analysis of single nucleotide po...

journal_title：Cytokine

authors： Bozzi A,Reis BS,Pereira PP,Pedroso EP,Goes AM

更新日期：2009-12-01 00:00:00

abstract：AIM:High mobility group box 1 protein (HMGB1) has been identified as a late proinflammatory cytokine and plays a key role in immune regulation. However, it is not yet clear whether HMGB1 can induce the activation and differentiation of dendritic cell (DC) subsets and subsequently modulate immune function of T cells. Th...

journal_title：Cytokine

authors： Liu QY,Yao YM,Yan YH,Dong N,Sheng ZY

更新日期：2011-05-01 00:00:00

abstract：:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid...

journal_title：Cytokine

authors： Pickkers P,Netea MG,van der Meer JW,Smits P

更新日期：2002-12-07 00:00:00

abstract：:Patients admitted to a medical intensive care unit (ICU) are characterized by an activated immune system and exhibit a high mortality rate irrespective of the underlying cause of admission. Interleukin (IL)-33 has been shown to be protective in experimental sepsis models and it has been demonstrated that circulating l...

journal_title：Cytokine

authors： Krychtiuk KA,Stojkovic S,Lenz M,Brekalo M,Huber K,Wojta J,Heinz G,Demyanets S,Speidl WS

更新日期：2018-03-01 00:00:00

abstract：:Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies w...

journal_title：Cytokine

authors： de Lemos Rieper C,Galle P,Pedersen BK,Hansen MB

更新日期：2010-09-01 00:00:00

abstract：:The self-renewal capacity of germline derived stem cells (GSCs) makes them an ideal source for research and use in clinics. Despite the presence of active gene network similarities between embryonic stem cells (ESCs) and GSCs, there are unanswered questions regarding the roles of evolutionary conserved genes in GSCs. ...

journal_title：Cytokine

authors： Farshchian M,Matin MM,Armant O,Geerts D,Dastpak M,Nakhaei-Rad S,Tajeran M,Jebelli A,Shahriyari M,Bahrami M,Fallah A,Yaghoobi V,Mirahmadi M,Abbaszadegan MR,Bahrami AR

更新日期：2018-06-01 00:00:00

abstract：:Immunoincompetence is a profound problem in end-stage renal failure patients undergoing hemodialysis, and chronic inflammation with altered serum levels of inflammation markers has been reported. Gene expression patterns have had little relevance for leukocyte research so far because of limitations in transcript level...

journal_title：Cytokine

authors： Knerr K,Füth R,Hemsen P,Mohné W,Heinig A,Kleophas W,Scherbaum WA,Martin S

更新日期：2005-05-07 00:00:00

abstract：:We have isolated and sequenced a cDNA that contains the coding sequence of porcine interleukin 18 (IL-18) and the recombinant protein of porcine IL-18 was expressed using the baculovirus system. The open reading frame (ORF) of the porcine IL-18 cDNA is 579 base pairs (bp) in length and encodes 192 amino acids. The pre...

journal_title：Cytokine

authors： Muneta Y,Mori Y,Shimoji Y,Yokomizo Y

更新日期：2000-06-01 00:00:00