Abstract:
:The proinflammatory cytokines TNFalpha and IL-1beta are thought to play a role in the mechanism of septic vasodilatory shock. Most evidence indicate that the vascular effects these cytokines are mediated through increased expression of inducible nitric oxide synthase, whereas several animal studies report a more rapid vasorelaxant effect. We studied the direct vascular effects of TNFalpha and IL-1beta in human isolated resistance arteries (n=9) using a microvascular myograph. After precontraction with noradrenaline or a depolarising high potassium solution, TNFalpha and IL-1beta (up to 10(-8) M, alone or in combination) did not exert any relevant vasoactive effect. We conclude that, in contrast with some animal experiments, these cytokines exert no direct vasoactivity in human resistance arteries.
journal_name
Cytokinejournal_title
Cytokineauthors
Pickkers P,Netea MG,van der Meer JW,Smits Pdoi
10.1006/cyto.2002.2004keywords:
subject
Has Abstractpub_date
2002-12-07 00:00:00pages
244-6issue
5eissn
1043-4666issn
1096-0023pii
S1043466602920041journal_volume
20pub_type
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