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Vanillin as a new modulator candidate for renal injury induced by cisplatin in experimental rats.

Abstract：

:Cisplatin is commonly prescribed for the treatment of various solid tumors but its use is limited due to certain side effects and renal injury is a true example. Oxidative stress and inflammation may contribute to the cisplatin induced nephrotoxicity. Accordingly, we evaluated the effect of oral vanillin intake (100mg/kg body weight) daily for 4weeks to combat this hazard. The present results have demonstrated significant attenuation of oxidative stress and renal injury where reduced glutathione (GSH) showed significant increase along with malondialdehyde (MDA) decrease. Fibrotic markers like fibroblast growth factor-23 (FGF-23), transforming growth factor-β1 (TGF-β1), inflammatory mediators such as nuclear factor-κB (NF-κB) and tumor necrosis factor-α (TNF-α) showed also significant decrease in vanillin treated rats as compared with the control group. Renal function showed also significant improvement where urea and creatinine demonstrated significant decrease and the histopathological study presented a good support to the biochemical markers results. Our conclusion that vanillin is a potent antioxidant, anti-inflammatory and anti-fibrotic agent. Additionally, it is a good modulator candidate for the renal injury induced by cisplatin intake.

journal_name

Cytokine

journal_title

Cytokine

authors

Elseweidy MM,Askar ME,Elswefy SE,Shawky M

doi

10.1016/j.cyto.2017.07.025

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

260-265

eissn

1043-4666

issn

1096-0023

pii

S1043-4666(17)30225-9

journal_volume

99

pub_type

杂志文章

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